1 00:00:07,100 --> 00:00:09,080 It has been debated since the beginning of science. 2 00:00:09,080 --> 00:00:13,400 Whether who you are is seated in the mind or the soul. In fact, 3 00:00:13,420 --> 00:00:16,280 the debate gets muddled really quickly as philosophers discuss. 4 00:00:16,280 --> 00:00:17,880 If perhaps the mind is in the soul, 5 00:00:18,260 --> 00:00:23,080 or the adverse perhaps idea of the soul is part of the mind without 6 00:00:23,100 --> 00:00:26,240 any doubt, whichever interpretation you tend to lean towards, 7 00:00:26,540 --> 00:00:31,360 the physical squishy bioelectrical brain is an essential part of the picture and 8 00:00:31,360 --> 00:00:34,680 an essential part of however it is that we function. Make lunch, 9 00:00:35,070 --> 00:00:36,800 make inventions, and make love. 10 00:00:38,010 --> 00:00:41,670 If you wanna learn about cannabis health cultivation and technique efficiently 11 00:00:41,670 --> 00:00:44,550 and with good cheer, I encourage you to subscribe to our newsletter. 12 00:00:44,920 --> 00:00:47,430 We'll send you new podcast episodes as they come out, 13 00:00:47,430 --> 00:00:48,830 delivered right to your inbox, 14 00:00:48,840 --> 00:00:51,990 along with commentary on a couple of the most important news items from the 15 00:00:51,990 --> 00:00:53,070 week. And videos too. 16 00:00:53,560 --> 00:00:57,030 Don't rely on social media to let you know when a new episode is published. 17 00:00:57,580 --> 00:01:00,790 Sign up for the updates to make sure you don't miss an episode. Also, 18 00:01:01,050 --> 00:01:04,150 we give away very cool prizes to folks who are signed up to receive the 19 00:01:04,150 --> 00:01:04,660 newsletter. 20 00:01:04,660 --> 00:01:07,510 There's nothing else you need to do to win except receive that newsletter. 21 00:01:07,650 --> 00:01:11,590 So go to shaping fire.com to sign up for the newsletter this week and be entered 22 00:01:11,590 --> 00:01:14,150 in this month's and all future newsletter prize drawings. 23 00:01:15,250 --> 00:01:18,270 You are listening to Shaping Fire, and I'm your host, Shang Los. 24 00:01:18,890 --> 00:01:21,590 My guest today is Cannabinoid researcher state and laws. 25 00:01:22,120 --> 00:01:25,550 State and laws is an accredited health and wellness professional with an 26 00:01:25,550 --> 00:01:28,150 expertise in nutrition. And over 10 years in practice, 27 00:01:28,610 --> 00:01:32,550 he earned a degree in health sciences and is presently a cannabinoid researcher 28 00:01:32,580 --> 00:01:36,830 earning a PhD of medical science in the School of Biomedicine at the University 29 00:01:36,830 --> 00:01:37,950 of Adelaide Australia. 30 00:01:38,890 --> 00:01:42,470 Staton has served as the graduate research assistant for several grant research 31 00:01:42,470 --> 00:01:43,310 projects in Hawaii, 32 00:01:43,530 --> 00:01:46,830 and is currently a teaching assistant at the University of Adelaide Health and 33 00:01:46,830 --> 00:01:47,663 Medical Sciences. 34 00:01:48,330 --> 00:01:51,510 His research interests center on the nutraceutical properties of medical 35 00:01:51,990 --> 00:01:52,450 cannabis, 36 00:01:52,450 --> 00:01:56,190 and particularly he has been published five times regarding the neutral 37 00:01:56,190 --> 00:01:59,110 protective bioactivity of cannabis, prevalent terpenes, 38 00:01:59,250 --> 00:02:02,350 and its implication for the entourage effects of medical cannabis, 39 00:02:02,740 --> 00:02:06,110 full spectrum formulations, and potential use in dementia care. 40 00:02:06,930 --> 00:02:10,910 Staton is also the owner and founder of the nutrition Company, sprouting Soul, 41 00:02:11,040 --> 00:02:13,350 which advocates a holistic approach to wellness, 42 00:02:13,360 --> 00:02:15,430 predicated on ease and simplicity. 43 00:02:16,290 --> 00:02:20,230 Staten leads nutrition and yoga workshops on topics including detoxification, 44 00:02:20,780 --> 00:02:21,370 ketosis, 45 00:02:21,370 --> 00:02:25,470 and the art and science of living foods dedicated to a lifestyle of wellness. 46 00:02:25,890 --> 00:02:29,510 Staten Nest taught over 6,000 yoga classes in the U S A and Australia, 47 00:02:29,770 --> 00:02:33,950 and served as a lead facilitator for numerous yoga teacher trainings and 48 00:02:33,950 --> 00:02:36,750 masterclasses during the first set. 49 00:02:36,750 --> 00:02:41,110 Today we will understand what neurogenesis consists of and which cannabinoids 50 00:02:41,110 --> 00:02:45,150 encourage and support the creation of new brain cells. In the second set, 51 00:02:45,150 --> 00:02:48,790 we will learn about neuroprotection and how cannabinoids help us keep the brain 52 00:02:48,910 --> 00:02:52,710 cells we already have alive and functioning. And during the third set, 53 00:02:52,850 --> 00:02:55,470 we will focus specifically on cannabis supplementation, 54 00:02:55,470 --> 00:02:58,590 including dosing protocols for folks interested in health and longevity, 55 00:02:59,020 --> 00:03:02,800 as well as cannabis patients experiencing Alzheimer's disease and dementia. 56 00:03:03,230 --> 00:03:04,960 Welcome to Shaping Fire, Satan. 57 00:03:06,960 --> 00:03:08,500 I'm grateful to be here. Really. 58 00:03:08,500 --> 00:03:11,300 Glad to have you. So let's get right into it. You know, 59 00:03:11,300 --> 00:03:15,580 when we say that cannabidiol causes neurogenesis, 60 00:03:15,930 --> 00:03:18,780 what exactly do we mean by neurogenesis. 61 00:03:21,090 --> 00:03:24,780 That C b D promotes the creation of new brain cells? 62 00:03:26,200 --> 00:03:26,780 And is it, 63 00:03:26,780 --> 00:03:31,660 is it all types of brain cells or is it only particular varieties of brain 64 00:03:31,660 --> 00:03:36,340 cells that cannabidiol can, uh, cause to be produced? 65 00:03:37,850 --> 00:03:42,140 Well, I think we need to explain what neurogenesis is. Mm-hmm. 66 00:03:42,180 --> 00:03:46,740 and then break down how c b D plays a role in this process. 67 00:03:48,040 --> 00:03:48,873 Please. 68 00:03:49,760 --> 00:03:54,330 Alright, so if we're gonna break neurogenesis down into four different, 69 00:03:55,010 --> 00:03:59,410 I guess you could call them stages, and we're just fig we're, you know, 70 00:03:59,410 --> 00:04:00,290 we're figuring this out. 71 00:04:00,290 --> 00:04:05,010 It wasn't until 1965 that we found in the denate 72 00:04:05,530 --> 00:04:09,290 gyrus of the hippocampus that neurogenesis actually occurs. 73 00:04:09,830 --> 00:04:14,050 So we've been doing a lot since then to figure out how C B D can play a role. 74 00:04:14,390 --> 00:04:16,050 And look, we're still figuring out, 75 00:04:16,790 --> 00:04:19,570 but if we were to begin to address your question, 76 00:04:20,260 --> 00:04:24,930 where these cells multiply or begin to split is in the proliferation phase, 77 00:04:26,150 --> 00:04:28,130 and that this might be a stretch, 78 00:04:28,190 --> 00:04:30,490 and I'm gonna try to make an analogy with cannabis, 79 00:04:30,490 --> 00:04:34,290 because this takes a similar amount of time for a cell, 80 00:04:34,810 --> 00:04:39,410 a neural stem cell to multiply and then become a 81 00:04:39,730 --> 00:04:40,563 neuronal cell. 82 00:04:41,350 --> 00:04:44,730 So in the proliferation stage where these newborn neuro stem cells and the 83 00:04:44,730 --> 00:04:46,090 hippocampus begin to multiply, 84 00:04:46,190 --> 00:04:50,250 we could compare this to the flowering tops of the cannabis plant. 85 00:04:50,910 --> 00:04:55,370 And these neural stem cells could be the seeds inside this flowering top, 86 00:04:55,630 --> 00:04:59,250 and they begin to multiply in about two weeks. 87 00:04:59,320 --> 00:05:03,970 Then this integration stage takes place, and that's after say, 88 00:05:03,970 --> 00:05:05,890 the seeds transverse to the ground. 89 00:05:06,590 --> 00:05:10,770 And these neuronal stem cells migrate to certain areas within the brain. 90 00:05:11,280 --> 00:05:16,170 They begin to d differentiate and start to spread out their axons and 91 00:05:16,410 --> 00:05:20,370 dendrites forming these neuronal like projections and becoming more specialized 92 00:05:20,470 --> 00:05:24,250 as a neuron oligodendrocyte or astri. 93 00:05:24,250 --> 00:05:29,170 So that's sort of the phase where they change their specific function 94 00:05:29,870 --> 00:05:32,410 in the neurogenesis, uh, process. 95 00:05:33,270 --> 00:05:37,570 And that's very similar to say like a cannabis seed sprouting in the ground, 96 00:05:38,650 --> 00:05:39,490 forming its roots, 97 00:05:39,590 --> 00:05:43,330 and also beginning to project its fan like leaves up towards the, 98 00:05:43,470 --> 00:05:48,010 the sunlight to receive photosynthesis and also 99 00:05:48,010 --> 00:05:51,490 nutrition from the soil. And then as these neural cells differentiate, 100 00:05:52,280 --> 00:05:57,160 they actually start to receive communication from other neuronal cells, uh, 101 00:05:57,420 --> 00:06:01,560 and stabilize and begin attempting to establish functional connections such as 102 00:06:01,560 --> 00:06:05,320 receiving neurotransmitter signals, as well as trophic support, 103 00:06:05,330 --> 00:06:09,160 which is the feeding and nutrition, and also pro survival factors, 104 00:06:09,170 --> 00:06:11,640 which we'll talk a little bit about throughout this conversation, 105 00:06:11,670 --> 00:06:16,400 such as blood to Thrive, neuro OIC factor, neuro growth factor, 106 00:06:16,620 --> 00:06:20,960 and a couple other chemicals that float around and sort of support this, uh, 107 00:06:21,170 --> 00:06:25,360 maturation process. And it ends up, in the best case scenario, 108 00:06:25,360 --> 00:06:26,360 about six to eight weeks, 109 00:06:26,360 --> 00:06:30,200 which you might be able to educate me a little bit more on, which is in my, uh, 110 00:06:30,200 --> 00:06:34,760 understanding is about the same amount of time it takes a seed to turn into a 111 00:06:35,000 --> 00:06:38,440 cannabis plant. Does that make any sense? Oh. 112 00:06:38,440 --> 00:06:42,000 It's six to eight weeks for flowering. Probably another four if you include veg, 113 00:06:42,000 --> 00:06:44,960 but yeah, we're with you. And, and since we're talking about timeframe, 114 00:06:45,500 --> 00:06:50,440 I'm really surprised that there are, like, we're looking at this neurogenesis, 115 00:06:51,060 --> 00:06:55,360 um, timeline on a scale of weeks. The facts, 116 00:06:55,580 --> 00:06:58,360 the fact that this, um, this, this, you know, 117 00:06:58,360 --> 00:07:02,400 this brain stem cell gets created and then it takes time to, um, you know, 118 00:07:02,450 --> 00:07:07,280 split and mature and migrate and then become the type of cell 119 00:07:07,280 --> 00:07:11,640 it's gonna be. In my mind, you know, when, when I see, 120 00:07:12,340 --> 00:07:17,000 um, uh, you know, illustrations on, on, you know, 121 00:07:17,020 --> 00:07:19,800 TV or the internet, all this stuff happens like really fast, right? 122 00:07:19,820 --> 00:07:21,520 The thing just moves and goes, and it happens. 123 00:07:22,060 --> 00:07:25,040 The fact that anything in the brain might take, you know, 124 00:07:25,180 --> 00:07:28,560 two to four weeks to develop and get to where it's going, 125 00:07:28,950 --> 00:07:33,600 that seems like a glacier pace to me for the brain. 126 00:07:33,740 --> 00:07:38,000 But, you know, uh, I, I'm a, I'm a novice at, at understanding, um, 127 00:07:38,000 --> 00:07:38,880 neuroscience, right? 128 00:07:38,880 --> 00:07:42,360 So it would make sense that I would have some incorrect expectations. 129 00:07:43,520 --> 00:07:47,600 I mean, but the, the multiplication phase, you know, from my research, 130 00:07:47,920 --> 00:07:49,720 I can say that it happens quite quickly. 131 00:07:49,850 --> 00:07:54,720 We're all see cells double or triple within two to three days in the lab. 132 00:07:55,060 --> 00:07:55,380 Um, 133 00:07:55,380 --> 00:07:59,720 and that's probably the most tangible thing that I can say as far as being able 134 00:07:59,720 --> 00:08:01,120 to see it happen mm-hmm. , um, 135 00:08:01,140 --> 00:08:06,000 in real time versus reading about it. So yeah, it's, uh, 136 00:08:06,160 --> 00:08:09,360 I think we're all learning about the exact timeline of this. 137 00:08:10,040 --> 00:08:13,760 I can imagine as a research scientist that when you're in the lab and you're 138 00:08:14,480 --> 00:08:18,720 visibly watching these neuronal stem cells, um, 139 00:08:18,990 --> 00:08:23,280 splitting over these two or three days, that it's a kind of exciting, 140 00:08:23,420 --> 00:08:27,640 and b maybe even makes you feel like you're having like kid like, oh, 141 00:08:27,640 --> 00:08:30,120 these are my babies, you know, these are my, you know, I'm, 142 00:08:30,140 --> 00:08:33,240 I'm growing these for research and I gotta take care of 'em and make sure 143 00:08:33,240 --> 00:08:35,200 they're fed correctly and everything. I would think that, 144 00:08:35,200 --> 00:08:39,560 that you would have a lot of, um, like, uh, care emotions for them. 145 00:08:39,680 --> 00:08:42,440 I don't know, maybe I'm anthropomorphizing too much, but I think I would care. 146 00:08:43,580 --> 00:08:47,590 Yeah, I would say so. I'm sort of, my life is sort of dictated by them. Uh, 147 00:08:47,670 --> 00:08:51,150 I don't really have a schedule. My schedule's based off of the cell growth and, 148 00:08:51,650 --> 00:08:54,590 um, and also if I decide to differentiate them, 149 00:08:54,590 --> 00:08:58,960 that's another 48 hours with certain chemicals. So yeah, 150 00:08:59,430 --> 00:08:59,720 they. 151 00:08:59,720 --> 00:09:02,880 Uh, the fact that they run your life may is making them sound more like kids. 152 00:09:03,200 --> 00:09:06,480 . Yeah, . All right. So lemme get you back into your timeline. So, 153 00:09:06,500 --> 00:09:10,920 so we, we've under, we've understood what happens, you know, regularly. So, um, 154 00:09:11,000 --> 00:09:14,640 I think where you were going next was, um, what adding, uh, 155 00:09:14,710 --> 00:09:19,480 cannabidiol C b D to this interaction does to, uh, 156 00:09:19,480 --> 00:09:20,600 encourage it probably. 157 00:09:21,350 --> 00:09:25,680 Yeah. So we'll talk first about the indirect way and then the direct way. 158 00:09:25,820 --> 00:09:30,520 So the indirect way that C B D can help in the proliferation phase and the 159 00:09:30,760 --> 00:09:34,520 multiplication phase is by increasing anandamide, 160 00:09:34,890 --> 00:09:39,120 which is the bliss molecule that is an endogenous cannabinoid. 161 00:09:39,820 --> 00:09:44,680 And it does this by sort of blocking fa or 162 00:09:44,850 --> 00:09:47,240 fatty acid amide hydroxylase, 163 00:09:47,330 --> 00:09:50,760 which is an end enzyme that breaks down the Hyde and 164 00:09:51,810 --> 00:09:56,320 anandamide has the ability to bind to the CB one and the CB two receptor, 165 00:09:56,330 --> 00:09:59,720 which has been shown to promote cell proliferation. Mm-hmm. 166 00:10:00,460 --> 00:10:04,800 So that's in the first phase. So I would say that C B D, you know, 167 00:10:05,180 --> 00:10:09,680 has its way to sort of tone up the 168 00:10:09,700 --> 00:10:13,480 endocannabinoid system to promote the first stage of neurogenesis. 169 00:10:14,540 --> 00:10:19,440 And then C B D can influence cell proliferation directly 170 00:10:19,540 --> 00:10:21,800 by binding to the transient placenta, 171 00:10:22,150 --> 00:10:24,920 potential Vanilla Lloyd type one, 172 00:10:24,920 --> 00:10:28,200 or let's just call these things T rrp V one receptor, 173 00:10:28,260 --> 00:10:31,880 and the five HT one A receptor, which is the serotonin receptor, 174 00:10:32,610 --> 00:10:34,480 which is demonstrated to help, you know, 175 00:10:34,480 --> 00:10:39,240 the cell proliferation is also also blood derived nootropic factor, 176 00:10:39,250 --> 00:10:43,880 which, uh, C B D can also promote, not only helps with cell proliferation, 177 00:10:44,420 --> 00:10:47,760 but also with the activation, uh, 178 00:10:47,860 --> 00:10:52,760 the differentiation and also helping the dendra complexity, 179 00:10:52,760 --> 00:10:56,800 which would form into the maturation phases as well as synaptic formation and 180 00:10:56,850 --> 00:10:58,800 plasticity of these newborn neurons. 181 00:10:59,700 --> 00:11:02,960 So through these T R P V one receptors, 182 00:11:03,020 --> 00:11:07,400 the five HT one A receptors and the blood derived nootropic sort of 183 00:11:07,870 --> 00:11:11,720 promotion, it has different stages of, uh, 184 00:11:11,910 --> 00:11:13,920 helping the neurogenesis process. 185 00:11:15,110 --> 00:11:16,360 That was a great explanation. 186 00:11:16,560 --> 00:11:21,440 I really enjoy having hardcore research scientists who are in the lab 187 00:11:21,500 --> 00:11:26,360 all the time on the show because, you know, the fine mechanics and, 188 00:11:26,500 --> 00:11:29,360 and we're we're really interested in that and, and not, well, we're. 189 00:11:29,360 --> 00:11:31,640 Trying to figure it out. Yeah. It's really complicated. . 190 00:11:31,640 --> 00:11:34,840 Well, yeah, I mean, we all know that the science is active, right? But it's, 191 00:11:34,840 --> 00:11:36,960 it's, it's a lot different than talking to, um, 192 00:11:37,120 --> 00:11:41,040 a lay person who will give you the story of how it happens, like, 193 00:11:41,040 --> 00:11:43,680 like when patients talk to me, right? Like, like I, 194 00:11:43,840 --> 00:11:46,200 I might be able to describe those three things happening, 195 00:11:46,200 --> 00:11:50,360 but I'm not gonna have the mastery of the language like you have that I think 196 00:11:50,360 --> 00:11:52,880 just makes us all feel like a bit more confident that, 197 00:11:53,030 --> 00:11:57,280 that we're learning the good stuff, right? So, so I appreciate that. So, 198 00:11:57,620 --> 00:12:02,240 so as far as thinking about those, those those three, um, 199 00:12:02,970 --> 00:12:07,680 those three ways that, that cannabidiol supports neurogenesis, um, 200 00:12:08,420 --> 00:12:10,640 is it, is it a fair model to think that what, 201 00:12:10,710 --> 00:12:15,480 what happens when we take C B D is we are essentially like turning up 202 00:12:15,500 --> 00:12:19,760 the governor on the engine a little bit because your brain will naturally do 203 00:12:19,760 --> 00:12:22,960 these three processes, but when you add C B D, 204 00:12:23,540 --> 00:12:26,480 it makes the whole process happen, um, 205 00:12:26,990 --> 00:12:30,680 with more gusto and, and so like, maybe, 206 00:12:30,930 --> 00:12:32,120 maybe quicker and more. 207 00:12:33,350 --> 00:12:38,000 Yeah, that's a, a good way to look at it. I was gonna explain it. Uh, 208 00:12:38,100 --> 00:12:42,680 as a, if you, if you play guitar, so you're like tuning your guitar, um, 209 00:12:42,890 --> 00:12:46,680 while the chords of each of the guitar or while a strings of each guitar acts, 210 00:12:46,680 --> 00:12:51,080 you're on a different note when you tune them correctly and you play that note, 211 00:12:51,150 --> 00:12:56,080 that sound travels with more precision and actually has a chord or a, 212 00:12:56,480 --> 00:13:00,600 a tone. And so I would say that C B D helps with the overall, 213 00:13:01,460 --> 00:13:03,760 uh, tone of neurogenesis. 214 00:13:04,300 --> 00:13:07,520 Ah, so by your description, what then, 215 00:13:07,640 --> 00:13:11,120 one of the things that CB does is increase the efficiency of this whole thing. 216 00:13:11,500 --> 00:13:12,480 Yep. Got it. 217 00:13:12,480 --> 00:13:17,400 Because all these things are happening regardless of with C B D in or outta the 218 00:13:17,400 --> 00:13:20,000 body by putting it in, like you said, to rev up the engine, 219 00:13:20,000 --> 00:13:21,760 it's actually like turning up the, 220 00:13:21,900 --> 00:13:25,800 the volume slightly through a coordination of events. 221 00:13:27,950 --> 00:13:28,490 I get it. 222 00:13:28,490 --> 00:13:33,230 So ev everybody is where they need to be when the 223 00:13:33,260 --> 00:13:36,310 performance starts and everybody's got all the resources they need. 224 00:13:36,410 --> 00:13:39,710 So the whole manufacturing team is just efficient and ready to go. 225 00:13:40,250 --> 00:13:40,730 Yep. 226 00:13:40,730 --> 00:13:43,670 Got it. So, um, you know, 227 00:13:45,340 --> 00:13:49,270 when we talk about neurogenesis in the, um, 228 00:13:49,830 --> 00:13:52,510 cannabis world, um, we're, 229 00:13:52,520 --> 00:13:57,390 we're usually exclusively talking about C B D because that's what most 230 00:13:57,410 --> 00:14:01,870 people are familiar with as a cannabinoid that causes neurogenesis. Um, 231 00:14:02,690 --> 00:14:07,350 but I know that we're continuing of course to expand our research to other novel 232 00:14:07,350 --> 00:14:08,790 cannabinoids. Um, 233 00:14:09,250 --> 00:14:13,870 are we familiar with any other cannabinoids that cause neurogenesis 234 00:14:14,050 --> 00:14:16,070 in addition to C B D yet? 235 00:14:17,500 --> 00:14:20,630 Yeah, I would go with, uh, delta nine, 236 00:14:20,870 --> 00:14:24,110 T H C as the other, um, 237 00:14:25,960 --> 00:14:30,470 Major phytocannabinoid that has been recognized as a 238 00:14:30,630 --> 00:14:35,470 promoter of neurogenesis in alignment with its function 239 00:14:36,260 --> 00:14:40,670 like anandamide and its ability to have an affinity 240 00:14:41,210 --> 00:14:43,350 to that CCB one, CCB two receptor, 241 00:14:43,600 --> 00:14:48,470 which along with that brain derived nootropic factor is 242 00:14:48,470 --> 00:14:51,030 what causes that first stage of neurogenesis. 243 00:14:51,460 --> 00:14:53,520 And in a wrap model, 244 00:14:53,720 --> 00:14:58,200 I think it was around 1.5 milligrams a kilo, which they called, uh, 245 00:14:59,280 --> 00:15:03,520 somewhat lower dose acute and chronically administered to a certain amount of 246 00:15:03,520 --> 00:15:04,220 time, 247 00:15:04,220 --> 00:15:08,600 it did show that it enhanced neurogenesis cognitive function and performance. 248 00:15:09,500 --> 00:15:14,440 And so if we looked at the sort of function of delta nine T H c, 249 00:15:14,540 --> 00:15:18,360 I'd maybe extend that. Maybe it's a bit of a stretch to delta eight, 250 00:15:19,000 --> 00:15:23,520 'cause it does have some binding ability to CB one and CB two and maybe even C B 251 00:15:23,640 --> 00:15:28,640 N, which even has a lesser degree of binding ability to those two receptors. 252 00:15:29,080 --> 00:15:33,920 Hmm. So when we're, when we're looking at the other, um, 253 00:15:35,460 --> 00:15:39,520 uh, significant neurogenesis agent in, 254 00:15:39,620 --> 00:15:44,400 in D nine T H C, um, is it essentially, um, 255 00:15:45,550 --> 00:15:50,280 helping neurogenesis in the same three areas of 256 00:15:50,390 --> 00:15:54,960 process as the C B D or is it mostly just at the first 257 00:15:55,110 --> 00:15:59,800 step since both C B D and D nine T H C are acting on the 258 00:15:59,890 --> 00:16:03,240 anandamide, which, which helps that first step is, 259 00:16:03,380 --> 00:16:05,600 is T H C helping all the way in the, 260 00:16:05,740 --> 00:16:10,080 all the way down the line in those three different timeframes like C, b, D does? 261 00:16:10,180 --> 00:16:12,400 Or is it really mostly just there at the beginning? 262 00:16:14,900 --> 00:16:18,440 Uh, it's a good question. I would have to look into, you know, 263 00:16:19,060 --> 00:16:23,120 how much Delta nine plays a role in differentiation and integration mm-hmm. 264 00:16:23,160 --> 00:16:25,640 as well as the maturation of the brain cell. 265 00:16:25,900 --> 00:16:27,600 And I think that could get into to the, 266 00:16:27,600 --> 00:16:31,120 some of that controversial application of, uh, 267 00:16:31,440 --> 00:16:35,320 T H C and timeframes in life. Mm-hmm. . But my guess would be, yes, 268 00:16:35,700 --> 00:16:39,360 it does play a role in the development of the brain cell. 269 00:16:40,040 --> 00:16:44,920 Interesting. All right. So, um, let's, let's switch sides of the equation here. 270 00:16:45,060 --> 00:16:48,800 So, so up to this point we've been talking about the, the, you know, 271 00:16:48,900 --> 00:16:52,480 the C B D and T H C helping, uh, and, and, 272 00:16:52,580 --> 00:16:57,560 and making this neurogenesis process more efficient and more robust. 273 00:16:58,020 --> 00:17:01,120 Um, these, these, these neuronal, um, 274 00:17:01,870 --> 00:17:03,360 stem cells that split, 275 00:17:03,370 --> 00:17:08,160 split split and then they mature and then they migrate to where they're going to 276 00:17:08,180 --> 00:17:11,480 become the kind of cell they're, they're going to become. Um, 277 00:17:13,460 --> 00:17:17,320 can these neuronal stem cells, um, 278 00:17:17,710 --> 00:17:21,320 turn into any sort of cell in the brain, 279 00:17:21,820 --> 00:17:24,280 or are they only particular flavors? 280 00:17:25,630 --> 00:17:28,360 When you mean particular cell of the brain, 281 00:17:28,470 --> 00:17:30,760 they can become a neuronal cell, 282 00:17:30,980 --> 00:17:35,720 an oligodendrocyte or an astrocyte from my understanding, 283 00:17:36,060 --> 00:17:41,040 and to a certain degree, different areas of the brain. Uh, 284 00:17:41,200 --> 00:17:43,920 I think it was, we just recently saw how this, 285 00:17:44,070 --> 00:17:47,560 this kind of occur in the hypothalamus, the raum, 286 00:17:47,860 --> 00:17:49,120 the substantial negra. 287 00:17:49,780 --> 00:17:53,280 And I think we're finding maybe some more areas of the brain where this does 288 00:17:53,290 --> 00:17:54,030 occur. 289 00:17:54,030 --> 00:17:56,560 Alright. On that is a good answer. And I, 290 00:17:56,560 --> 00:17:59,800 and I'm also going to change my question a little bit to get at something a 291 00:17:59,800 --> 00:18:03,640 little different, which is, um, what if I were to change the question and say, 292 00:18:04,220 --> 00:18:08,760 are there any brain cells that cannot be 293 00:18:09,400 --> 00:18:11,840 replaced by this neurogenesis that we described. 294 00:18:14,580 --> 00:18:16,670 Like areas of the brain that this. 295 00:18:16,670 --> 00:18:18,230 Cannot not happen? Yeah, that might, yeah. The idea, the, what I'm, 296 00:18:18,230 --> 00:18:20,470 what I'm trying to get to is that it, it, it, you know, 297 00:18:20,470 --> 00:18:23,990 neurogenesis is great and if it can replace all the parts in of our brain, 298 00:18:23,990 --> 00:18:27,590 that's even cooler. But if there are some parts of our brain that, 299 00:18:27,700 --> 00:18:30,510 that just can never benefit from neurogenesis, 300 00:18:30,610 --> 00:18:31,830 I'd be curious to know what it is. 301 00:18:32,860 --> 00:18:35,990 Yeah, that's a good question. And I can't answer that specifically, 302 00:18:36,090 --> 00:18:38,430 but I have hope that the answer is yes. 303 00:18:38,700 --> 00:18:40,550 Okay. Fair enough. Fair enough. And you know, and, 304 00:18:40,570 --> 00:18:44,590 and this is what happens when we do an interview on the edge of, of the science, 305 00:18:44,650 --> 00:18:47,430 we know, right? So we're, we're probably gonna run into some stuff like that. 306 00:18:48,290 --> 00:18:49,350 Mm-hmm. . 307 00:18:52,140 --> 00:18:54,350 Okay. So if, if we're clear now that, uh, 308 00:18:54,630 --> 00:18:58,070 C b D and T H C can help along the neurogenesis, and, 309 00:18:58,290 --> 00:19:00,870 and we know that neurogenesis can, uh, 310 00:19:00,870 --> 00:19:04,470 replace an entire variety of, uh, of, 311 00:19:04,530 --> 00:19:09,390 of different types of, of, of brain cells, um, uh, 312 00:19:09,750 --> 00:19:12,030 I wanna look at a potential, um, 313 00:19:12,360 --> 00:19:17,230 other limiting factors that could slow down this neurogenesis since kind of the 314 00:19:17,230 --> 00:19:20,990 point of today is what is neurogenesis and how can we, you know, encourage it? 315 00:19:20,990 --> 00:19:25,670 Right? So, so, um, are there other inputs and, 316 00:19:25,670 --> 00:19:28,190 and there might be too many dimension, I'm open to this, but, 317 00:19:28,210 --> 00:19:32,910 but are there other inputs that need to be present, um, uh, 318 00:19:33,500 --> 00:19:34,510 that, um, 319 00:19:34,810 --> 00:19:38,870 if not present is going to reduce the ability of 320 00:19:39,260 --> 00:19:43,550 cannabidiol and T H C to do this, um, 321 00:19:44,110 --> 00:19:48,790 increase of efficiency and increase in robustness of this 322 00:19:48,790 --> 00:19:52,670 process? And, and, and what I imagine you might say is, oh, 323 00:19:52,850 --> 00:19:57,470 it needs this particular, um, brain chemical five H T P. 324 00:19:57,490 --> 00:19:58,310 And so, you know, 325 00:19:58,310 --> 00:20:03,030 we encourage people to take supplements to also encourage neurogenesis 326 00:20:03,200 --> 00:20:05,710 along with the C B D and T H C. 327 00:20:07,830 --> 00:20:11,030 I think the easiest way to answer that would be health. 328 00:20:11,570 --> 00:20:13,550 Oh, right. On whole food diet, . But. 329 00:20:14,010 --> 00:20:16,030 But, uh, get exercise, let's, uh, 330 00:20:16,240 --> 00:20:21,150 break health down into three categories. We'll start with oxygen, 331 00:20:21,320 --> 00:20:25,750 which, you know, we, we gotta have that you hold your breath and you eventually, 332 00:20:26,090 --> 00:20:29,030 no brain cells will be doing much anymore. . Uh, 333 00:20:29,180 --> 00:20:33,910 next thing we need is hydration or H two O or, you know, water and, 334 00:20:34,050 --> 00:20:38,910 uh, nutrients. And so more specifically, when we sort of say, okay, 335 00:20:38,910 --> 00:20:42,470 well we can get air and water, we sort of take that a little bit for granted, 336 00:20:42,470 --> 00:20:46,190 hopefully it's both clean air and water and we get into nutrients. 337 00:20:46,310 --> 00:20:49,960 I would say probably the number one would be long chain fatty acids, 338 00:20:49,960 --> 00:20:54,600 particularly omega threes play a, a pretty good role in, uh, 339 00:20:54,630 --> 00:20:57,360 some of these processes that promote neurogenesis. 340 00:20:58,180 --> 00:21:01,640 The second one would be polyphenols, uh, 341 00:21:01,830 --> 00:21:06,760 more specifically flavonoids. And then the third would be a healthy microbiome. 342 00:21:07,380 --> 00:21:11,920 And we, we can get into those three if you'd like. And what supplements may be, 343 00:21:11,920 --> 00:21:16,000 would be best if that wasn't part of your whole food diet approach. 344 00:21:17,330 --> 00:21:21,760 Right. On. Let's hold on, uh, on that, that next protocol question and like, 345 00:21:21,830 --> 00:21:25,280 what and how much to take for the third set. 'cause I've got that. Yep. 346 00:21:25,600 --> 00:21:29,200 I got that sitting down there to talk about. So, alright. So, um, 347 00:21:30,460 --> 00:21:34,400 so assuming all these components are in place, um, 348 00:21:35,100 --> 00:21:39,720 do we know about a dosage threshold for, uh, 349 00:21:40,160 --> 00:21:43,360 C B D to cause neurogenesis, essentially, 350 00:21:43,380 --> 00:21:48,160 how much do we need to take for this process to be improved at all? 351 00:21:49,560 --> 00:21:50,250 Oh. 352 00:21:50,250 --> 00:21:55,180 Well, I think most of our research that could get around a dosage comes from 353 00:21:55,520 --> 00:21:59,140 either in vitro, which means cellular or in vivo, 354 00:21:59,140 --> 00:22:01,660 which is basically rat models. 355 00:22:02,720 --> 00:22:07,660 And if I was to condense everything I've read up to this point, 356 00:22:07,920 --> 00:22:11,780 it would be around three to 10 milligrams per kilogram. 357 00:22:12,160 --> 00:22:16,860 And that becomes pretty hard to translate in a human due to 358 00:22:17,800 --> 00:22:20,780 the bioavailability and, uh, 359 00:22:21,000 --> 00:22:25,660 as well as where we're at with understanding how it even interacts 360 00:22:25,660 --> 00:22:29,500 different inside the human versus other, uh, 361 00:22:30,580 --> 00:22:31,413 creatures. 362 00:22:31,800 --> 00:22:33,620 Um, me meaning that, um, 363 00:22:33,800 --> 00:22:37,900 you can make this guesstimate based on the lab science, 364 00:22:38,680 --> 00:22:39,200 but, 365 00:22:39,200 --> 00:22:44,100 but you just doing like a quick scale up based on your experience, 366 00:22:44,600 --> 00:22:49,420 you're saying upfront that it would be hard to defend this number 'cause we 367 00:22:49,420 --> 00:22:53,070 don't really know yet. Correct. Okay, got it. But. 368 00:22:53,470 --> 00:22:57,230 CB D'S a a relatively safe molecule, 369 00:22:58,010 --> 00:23:02,950 so it's therapeutic range is probably gonna be 370 00:23:02,950 --> 00:23:03,783 best, uh, 371 00:23:05,910 --> 00:23:10,700 gauge at what condition you might be trying to use it 372 00:23:10,720 --> 00:23:11,700 for. Um, 373 00:23:11,720 --> 00:23:15,940 and I think the idea of using it for neurogenesis is really unexplored, 374 00:23:15,950 --> 00:23:19,140 especially in humans. So we, we have to, 375 00:23:20,890 --> 00:23:23,550 you know, traverse slowly with that recommendation. 376 00:23:24,020 --> 00:23:28,270 Yeah, I, I, I understand that. I mean, that's one of the reasons why I, I, 377 00:23:28,270 --> 00:23:32,030 it took so long me, for me to find you and hunt you down in Australia. Right. 378 00:23:32,030 --> 00:23:36,390 There's just not a lot of people who are doing this particular work that you're 379 00:23:36,390 --> 00:23:40,590 working on, um, around cannabinoids and neurogenesis. Um, 380 00:23:41,130 --> 00:23:42,670 you know, uh, uh, I'm, 381 00:23:42,690 --> 00:23:45,680 I'm gonna ask you a quick math question just because you play with these numbers 382 00:23:45,780 --> 00:23:47,760 all the time. Um, but you know, 383 00:23:47,940 --> 00:23:51,800 the three to 10 milligrams per kilogram a day, you know, 384 00:23:51,820 --> 00:23:53,640 the very rough guesstimate that you gave, 385 00:23:54,020 --> 00:23:57,040 do you have an idea of how many milligrams a day that is for, say, 386 00:23:57,280 --> 00:23:59,520 somebody who's 150 pounds? We don't do metric here, 387 00:23:59,520 --> 00:24:02,240 so I haven't gone back and forth between, you. 388 00:24:02,240 --> 00:24:04,680 Know. Yeah, I think that's around about 70 kilos. 389 00:24:04,780 --> 00:24:08,280 So you say that upper threshold times 10, 390 00:24:08,330 --> 00:24:10,400 700 milligrams a day. Cool. 391 00:24:10,400 --> 00:24:11,240 Thank you. Appreciate. 392 00:24:11,300 --> 00:24:12,920 You doing that. Uh, lower threshold, uh, 393 00:24:12,920 --> 00:24:15,520 let's just say you weigh more and make the numbers easier. 394 00:24:15,780 --> 00:24:20,520 Say you weigh a hundred kilos and three milligram dosage would be on the lower 395 00:24:20,580 --> 00:24:24,000 end around 300, uh three. No, no. Got, 396 00:24:24,000 --> 00:24:27,760 I think a recent study just came out that synthesized all the literature that 397 00:24:27,760 --> 00:24:32,000 they've done in human studies and said the safe dose is around 60 to a hundred 398 00:24:32,600 --> 00:24:36,480 milligrams per day. So, uh. 399 00:24:36,810 --> 00:24:40,920 60 To a hundred milligrams per day when we were talking about 300 to 700. 400 00:24:41,310 --> 00:24:43,240 Yeah. That's more the therapeutic range. 401 00:24:43,560 --> 00:24:44,760 I see, I see. Yeah. 402 00:24:45,300 --> 00:24:49,920 So we talk a lot here on shaping fire about the compare and contrast 403 00:24:50,230 --> 00:24:54,960 between, um, isolates and whole plant medicine. And, 404 00:24:55,060 --> 00:24:58,960 you know, anybody who listens to the show knows that, uh, I'm no, 405 00:24:59,180 --> 00:25:04,080 I'm no stranger to be pushing whole plant medicine versus isolates. 406 00:25:04,080 --> 00:25:07,600 While, while definitely also understanding that isolates have their place. 407 00:25:07,740 --> 00:25:08,220 For example, 408 00:25:08,220 --> 00:25:12,800 if you need a novel cannabinoid and it makes sense for you to spike your, 409 00:25:13,110 --> 00:25:14,720 your cannabis oil because you're, 410 00:25:14,720 --> 00:25:18,840 you need a cannabinoid that's very hard for you to get or to grow or something 411 00:25:18,840 --> 00:25:20,400 like that. Um, like, 412 00:25:20,400 --> 00:25:24,640 like many of us did in the early days before we had access to C B D plants, 413 00:25:24,700 --> 00:25:29,320 but we could get C b D isolate from Europe. Um, and, and I, 414 00:25:29,380 --> 00:25:33,240 and I also know that most of these studies are using isolates because the 415 00:25:33,240 --> 00:25:35,160 studies, um, you know, are, they're, 416 00:25:35,160 --> 00:25:39,880 they're looking to set up future pharmacology and they want the 417 00:25:39,960 --> 00:25:42,960 isolates so that they can, you know, reproduce their results. 418 00:25:43,580 --> 00:25:48,240 And also it is just, you know, a lot easier and, and less, um, I don't know, 419 00:25:48,600 --> 00:25:52,800 sloppy to work with isolates than it is trying to deal with, you know, 420 00:25:53,000 --> 00:25:56,440 a a direct whole plant resin. All of that said, 421 00:25:57,140 --> 00:25:59,200 we also know that the, you know, 422 00:25:59,290 --> 00:26:04,000 we're big believers in the entourage effect and the fact that having, you know, 423 00:26:04,020 --> 00:26:07,480 groups of various cannabinoids together, they, they, 424 00:26:07,510 --> 00:26:10,160 they act synergistically with each other, um, 425 00:26:11,500 --> 00:26:13,280 so that everybody can do their job better. 426 00:26:13,660 --> 00:26:16,720 So all this just sets up this question. Um, 427 00:26:18,620 --> 00:26:22,480 do you think that you would get, um, a, 428 00:26:22,720 --> 00:26:27,520 a a better play from your C B D if you're, um, 429 00:26:27,660 --> 00:26:31,560 taking it in a whole plant cannabis oil, you know, 430 00:26:32,040 --> 00:26:36,400 commonly known to as like an R S O or something? Or, uh, do you find there's, 431 00:26:36,980 --> 00:26:38,440 or, or from your research, 432 00:26:38,440 --> 00:26:41,480 would you expect there's not gonna be any difference between the isolate and the 433 00:26:41,480 --> 00:26:44,480 whole plant? Or perhaps even it's, it's favoring the isolate, 434 00:26:44,480 --> 00:26:46,520 which will make me cry, but I'll believe you. 435 00:26:48,200 --> 00:26:50,320 I mean, that's a, that's a big question. Mm-hmm. , 436 00:26:50,320 --> 00:26:53,920 but we'll go with, uh, let's just look at C B D as a molecule first. 437 00:26:54,100 --> 00:26:58,840 So we could call that an isolate or C B D and what we've learned 438 00:26:59,260 --> 00:27:03,880 on a molecular functional level has mostly to do with the isolate. 439 00:27:04,540 --> 00:27:07,000 So if we were to say that's, you know, the, 440 00:27:08,500 --> 00:27:13,200 the backbone and we were to go whole plant, uh, that it, 441 00:27:13,550 --> 00:27:17,680 we'd maybe have to look at extraction methods and what is in that, uh, 442 00:27:17,730 --> 00:27:19,200 whole plant extract. 443 00:27:19,260 --> 00:27:23,040 But let's say that whole plant extract could be broken down into, 444 00:27:24,420 --> 00:27:26,720 uh, C B D, 445 00:27:28,120 --> 00:27:33,110 maybe some small, small amounts of other cannabinoids terpenes, which could be, 446 00:27:33,330 --> 00:27:35,150 you know, quite a few mm. 447 00:27:35,420 --> 00:27:36,510 Some can fla in. 448 00:27:36,510 --> 00:27:39,990 15 Something, and then you have your canna flavin on top of that. 449 00:27:40,570 --> 00:27:44,830 And each of those has a little bit of a role in 450 00:27:45,820 --> 00:27:50,510 therapeutic, uh, targets. So I would, you know, I'm a, I'm a whole plant, 451 00:27:50,810 --> 00:27:53,710 um, promoter as well. I would think you would get, uh, 452 00:27:54,140 --> 00:27:58,390 some sort of synergistic effect from a whole plant extract, 453 00:27:58,690 --> 00:28:03,550 and then we can get into maybe the bioavailability that it would enhance, 454 00:28:03,850 --> 00:28:06,870 uh, because terpenes do play a role in, you know, 455 00:28:06,900 --> 00:28:10,270 enhancing the bioavailability of, uh, cannabinoids. 456 00:28:10,530 --> 00:28:15,070 That's interesting. So, so, um, we would think that the, the, the, 457 00:28:15,170 --> 00:28:19,150 the whole resin preparation, um, would just, you know, 458 00:28:19,540 --> 00:28:21,830 join with our body systems at a, 459 00:28:22,090 --> 00:28:25,670 at an easier and less frictionous rate than a straight isolate would. 460 00:28:26,550 --> 00:28:27,350 I think so. Mm-hmm. , 461 00:28:27,350 --> 00:28:32,350 I think our body would be able to handle it more intelligently. 'cause that's, 462 00:28:32,890 --> 00:28:37,710 if we were to look at the, you know, the, maybe the potential of 10,000 years of 463 00:28:39,230 --> 00:28:44,190 co-evolution with the plant and the fact that we could have been using this 464 00:28:44,190 --> 00:28:45,190 plant for that long, 465 00:28:45,940 --> 00:28:49,910 then our body would have more of an intelligence with it as a whole plant 466 00:28:49,910 --> 00:28:51,430 extract than an isolate. 467 00:28:51,880 --> 00:28:54,110 Right on. So, um, we. 468 00:28:54,110 --> 00:28:57,350 Have seen like an observationally in patients with severe epilepsy. 469 00:28:57,440 --> 00:29:02,190 There have been notable improvements with far lower doses of C B D extract than 470 00:29:02,190 --> 00:29:06,870 purified C B D. So there is a little bit of, uh, clinical research around that, 471 00:29:07,610 --> 00:29:10,670 um, but not yet with neurogenesis. Right. 472 00:29:10,670 --> 00:29:14,550 On. Great. Thank you. Um, alright, one more question before we go to break and, 473 00:29:14,610 --> 00:29:17,230 and, and this one is kind of a corollary question, 474 00:29:17,330 --> 00:29:19,390 but doesn't really stem from the last one. So, 475 00:29:19,450 --> 00:29:24,190 so we've been talking about this neurogenesis process that we like to, uh, 476 00:29:24,290 --> 00:29:27,670 you know, turn up the volume on by taking C B D and and T H C. 477 00:29:28,290 --> 00:29:32,750 And so everything is happening more robustly and, um, um, 478 00:29:33,470 --> 00:29:35,470 I was gonna say aggressively, that's probably not the right word, 479 00:29:35,530 --> 00:29:37,430 but robustly, um, 480 00:29:38,610 --> 00:29:42,160 I'm assuming that there are some either, um, 481 00:29:44,120 --> 00:29:44,953 um, 482 00:29:46,300 --> 00:29:51,220 resources the brain may need or damage that may have occurred to the 483 00:29:51,230 --> 00:29:56,180 brain that is impeding neurogenesis that not even 484 00:29:56,320 --> 00:29:59,580 adding cannabidiol can overcome. 485 00:30:00,280 --> 00:30:04,500 And so what I'm specifically looking for are any suggestions you might have 486 00:30:05,160 --> 00:30:07,260 of, of, um, you know, 487 00:30:07,820 --> 00:30:12,420 pre-existing damage to the brain that might block C B D 488 00:30:12,610 --> 00:30:15,660 from doing its job because that, 489 00:30:15,690 --> 00:30:20,020 that brain issue is actually shutting down the, 490 00:30:20,240 --> 00:30:24,420 the neurogenesis in ways that the C B D cannot overcome. 491 00:30:25,990 --> 00:30:30,600 Yeah. I think that's when we start getting into, or this leads into, uh, 492 00:30:30,670 --> 00:30:35,640 Alzheimer's disease, you know, once you get beyond that point of dendra and uh, 493 00:30:36,660 --> 00:30:37,640 axonal breakage, 494 00:30:38,330 --> 00:30:43,160 there isn't much of a chance that anything's gonna save that 495 00:30:43,480 --> 00:30:47,640 neuronal cell. And if we look that as a collective hole or a neuronal circuitry, 496 00:30:48,260 --> 00:30:52,000 uh, connection line, and if a certain amount of it gets broken down, 497 00:30:52,150 --> 00:30:53,000 then you know, 498 00:30:53,000 --> 00:30:57,960 the chances of recovery are gonna be pretty minimal to that circuit. 499 00:30:58,300 --> 00:30:58,660 Uh, 500 00:30:58,660 --> 00:31:03,480 so getting on board sooner rather than later would make c b 501 00:31:03,560 --> 00:31:04,393 D more beneficial. 502 00:31:05,090 --> 00:31:09,520 Right on. Now, um, I know your specialty is more in Alzheimer's, 503 00:31:09,520 --> 00:31:13,840 which we talking about at more length later. Um, but the, 504 00:31:14,100 --> 00:31:18,040 the other disease that I'm often talking to patients about that involves 505 00:31:18,160 --> 00:31:22,680 neurogenesis is Parkinson's. And, um, you know, I've, 506 00:31:22,680 --> 00:31:25,680 I've I've been told by scientists, you know, just, you know, 507 00:31:25,880 --> 00:31:27,960 standing at conferences and stuff that, 508 00:31:27,990 --> 00:31:32,960 that one of the reasons why C B D helps Parkinson's patients is 509 00:31:32,960 --> 00:31:34,640 because it causes neurogenesis. 510 00:31:34,640 --> 00:31:39,280 Because a good deal of the impact from Parkinson's is because they are losing 511 00:31:39,290 --> 00:31:43,800 their dopamine excreting neurons. And, and, uh, 512 00:31:43,800 --> 00:31:46,920 that's a one-way trip if there's not neurogenesis. 513 00:31:47,340 --> 00:31:51,480 And so C B D is causing more of these, um, 514 00:31:51,730 --> 00:31:55,040 these brain cells to come into existence, which, um, 515 00:31:55,310 --> 00:31:59,040 kind of like holds the line on the Parkinson's to hold it from, 516 00:31:59,070 --> 00:32:00,160 from getting worse. 517 00:32:01,280 --> 00:32:05,840 A do you have any point of reference on this to speak to it? And, and, 518 00:32:05,980 --> 00:32:09,640 and b, does, uh, 519 00:32:10,060 --> 00:32:14,760 is that process potentially similar like to the one that we just described, 520 00:32:15,220 --> 00:32:17,760 um, around, um, Alzheimer's? 521 00:32:18,630 --> 00:32:20,680 Yeah. If we were looking at, um, 522 00:32:21,960 --> 00:32:26,880 a level of dopa meic neurons 523 00:32:26,900 --> 00:32:30,720 in their ability to produce dopamine, which I just kind of recently learned, 524 00:32:30,720 --> 00:32:33,960 about 80% of Parkinson's is, 525 00:32:34,220 --> 00:32:39,160 or is due to the lack of dopamine and due to the lack of the dopamine producing 526 00:32:39,310 --> 00:32:42,280 neurons. So if we could create more of these neurons, 527 00:32:42,280 --> 00:32:46,320 technically we could create more dopamine and effectively treat Parkinson's 528 00:32:46,320 --> 00:32:47,140 disease. 529 00:32:47,140 --> 00:32:51,240 And Parkinson's disease also has a protein very similar to Alzheimer's disease. 530 00:32:51,240 --> 00:32:55,000 So Alzheimer's disease, the main pathological hallmark is amyloid beta. 531 00:32:55,380 --> 00:32:57,800 And in Parkinson's it's alpha-synuclein. 532 00:32:58,020 --> 00:33:02,520 And C B D has shown or demonstrated in preclinical 533 00:33:02,960 --> 00:33:06,480 research that it stops the aggregation, not completely, 534 00:33:06,540 --> 00:33:10,960 but it will help augment some of the aggregation of these two proteins that 535 00:33:10,960 --> 00:33:14,440 create quite a toxic environment, extracellularly, 536 00:33:14,930 --> 00:33:19,160 which affects their function and eventually creates cell death or, 537 00:33:19,500 --> 00:33:20,360 you know mm-hmm. . 538 00:33:20,780 --> 00:33:21,460 Uh. 539 00:33:21,460 --> 00:33:25,640 The no longer functioning neurons which connect to each other and create a 540 00:33:25,840 --> 00:33:27,280 communication line throughout the brain. 541 00:33:28,060 --> 00:33:30,320 Wow, that's really interesting. Alright, cool. Well, 542 00:33:30,320 --> 00:33:31,520 thank you for that statement. Um, 543 00:33:31,810 --> 00:33:35,720 let's go ahead and take our first of two short breaks and we'll be right back. 544 00:33:36,220 --> 00:33:37,640 You are listening to Shaping Fire, 545 00:33:37,700 --> 00:33:41,240 and my guest today is Phytocannabinoid researcher state and laws 546 00:33:43,790 --> 00:33:44,360 Fish poop. 547 00:33:44,360 --> 00:33:48,280 Brand fertilizer is an all natural fish poop concentrate with nothing added. 548 00:33:48,830 --> 00:33:53,760 Real fish poop is extraordinarily complex. Not only are you adding the nitrogen, 549 00:33:54,160 --> 00:33:55,280 phosphorus, and potassium, 550 00:33:55,280 --> 00:33:58,520 your plants need to build mass transport nutrients and enhance flavor. 551 00:33:59,100 --> 00:34:03,640 But fish waste is also packed with biological activity and micronutrients. 552 00:34:04,230 --> 00:34:06,960 When you add fish poop to your irrigation water, 553 00:34:07,220 --> 00:34:10,840 you are adding life force probiotics and active microbes. 554 00:34:11,530 --> 00:34:15,400 These microorganisms include a wealth of various bacteria and protozoa, 555 00:34:15,410 --> 00:34:18,520 which further enhance nutrient availability for the plants. 556 00:34:19,270 --> 00:34:23,520 Because plants are limited by the absence of any essential micronutrient, 557 00:34:23,770 --> 00:34:27,560 these trace nutrients are the difference between having a decent garden and 558 00:34:27,560 --> 00:34:30,440 having a garden that makes you feel really proud of your efforts. 559 00:34:31,190 --> 00:34:35,360 Fish poop is a naturally complete solution that fills in the cracks in your 560 00:34:35,560 --> 00:34:39,920 fertilizer program to ensure you offer your garden a broad base of nutrients. 561 00:34:40,660 --> 00:34:42,680 Not all fish poop is created equally. 562 00:34:43,270 --> 00:34:47,440 Most products with added fish waste don't reveal their sources or lab results. 563 00:34:48,150 --> 00:34:50,360 Fish poop, brand fish poop, however, 564 00:34:51,160 --> 00:34:55,160 generates their own fish waste as a byproduct of their organic aquaponics 565 00:34:55,360 --> 00:34:58,400 cannabis farm where they raise ornamental, koi and tilapia, 566 00:34:59,060 --> 00:35:03,120 you are even invited to tour their farm in person or on their YouTube channel to 567 00:35:03,120 --> 00:35:03,953 look for yourself. 568 00:35:04,430 --> 00:35:08,080 This sort of transparency is wildly rare in the fertilizer market. 569 00:35:08,980 --> 00:35:13,880 The folks behind fish poop are also lifelong medical cannabis producers who have 570 00:35:13,880 --> 00:35:18,600 deep connections in the community donate more product than they sell and support 571 00:35:18,920 --> 00:35:22,000 cannabis prisoner, veteran and patient collectives and charities. 572 00:35:22,660 --> 00:35:25,120 To get your bottle of pure fish poop, 573 00:35:25,500 --> 00:35:30,360 go to fish poop.com and to see their entire line of cannabis products go to 574 00:35:30,360 --> 00:35:34,200 ounce of hope.com. 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You are listening to Shaping Fire. I am your host Shang Los, 631 00:39:07,220 --> 00:39:10,520 and my guest today is Phytocannabinoid Researcher State and Laws. 632 00:39:11,180 --> 00:39:12,720 So during the first set, we, 633 00:39:12,780 --> 00:39:17,720 we brought ourselves to an understanding of what neurogenesis is and how 634 00:39:18,160 --> 00:39:22,600 c b, d and T H c and to a lesser degree, some other cannabinoids, we think, 635 00:39:22,980 --> 00:39:27,480 um, encourage and, uh, cause neurogenesis to be, uh, 636 00:39:27,480 --> 00:39:30,000 more robust. Now, here in set two, 637 00:39:30,290 --> 00:39:33,920 we're gonna start talking about not how to, uh, 638 00:39:34,310 --> 00:39:37,640 make these new, um, brain cells. 639 00:39:37,650 --> 00:39:42,440 We're gonna talk about how to protect the ones we've got. So, um, so staton, 640 00:39:42,440 --> 00:39:44,480 you know, let's move on from neurogenesis. 641 00:39:44,690 --> 00:39:49,640 Which components of cannabis resin can be considered 642 00:39:50,420 --> 00:39:51,280 neuroprotectants, 643 00:39:51,980 --> 00:39:55,600 and can you give us a general definition of what that means? 644 00:39:59,720 --> 00:40:00,400 Yep. 645 00:40:00,400 --> 00:40:04,980 So if we get back to that ability to protect a neuronal cell from, 646 00:40:05,280 --> 00:40:08,420 um, cell death or from Misfunctioning, 647 00:40:09,150 --> 00:40:13,620 there are many different constituents or 648 00:40:13,940 --> 00:40:18,660 chemicals inside the cannabis plant that could be made into a cannabis 649 00:40:19,060 --> 00:40:23,420 resin that will protect neuronal cells from things like the 650 00:40:23,420 --> 00:40:26,660 inflammatory response and, uh, 651 00:40:27,290 --> 00:40:30,100 free radicals such as reactive oxygen species. 652 00:40:30,360 --> 00:40:34,700 So they can either act as an anti-inflammatory compound or an 653 00:40:34,970 --> 00:40:37,700 antioxidant to protect neuronal cells. 654 00:40:39,490 --> 00:40:43,420 That actually, when you, when put that, when put that way, you know, 655 00:40:43,480 --> 00:40:48,020 the fact that they are components of cannabis resin that decrease inflammation 656 00:40:48,180 --> 00:40:50,940 and free radicals. That's a lot of different stuff actually. 657 00:40:52,610 --> 00:40:54,700 Yeah. So that's, uh, that's the, 658 00:40:54,920 --> 00:40:59,580 the characterization of one compound and its ability to do multiple things 659 00:41:00,240 --> 00:41:02,860 in different systems or places in the body. 660 00:41:03,880 --> 00:41:06,860 So, so whereas when it comes to neurogenesis, 661 00:41:07,090 --> 00:41:11,620 looking at the variety of all the components of the resin, you know, it's, 662 00:41:11,620 --> 00:41:15,620 it's primarily C B D, certainly some amount, T h c, 663 00:41:16,030 --> 00:41:20,740 maybe a bit a few others. But when we talk about neuroprotection, um, 664 00:41:21,620 --> 00:41:23,820 cannabis resins, it's just essentially a soup of, 665 00:41:24,560 --> 00:41:28,620 of good things that actually protect our brain in various ways. 666 00:41:31,030 --> 00:41:31,280 Um. 667 00:41:31,280 --> 00:41:31,770 Yeah, I mean, 668 00:41:31,770 --> 00:41:36,520 if we start with the 545 identified compounds and we break that into 669 00:41:36,600 --> 00:41:41,360 140 terpenes, 104 cannabinoids, 26 flavonoids, 670 00:41:41,360 --> 00:41:42,180 20 steroids, 671 00:41:42,180 --> 00:41:46,440 and a whole bunch of lignin still being still OIDs and who the hell knows what 672 00:41:46,440 --> 00:41:49,200 else we're finding inside this in the next 20 years. Uh, 673 00:41:49,260 --> 00:41:52,480 and then we're mapping out their, uh, 674 00:41:52,550 --> 00:41:56,600 potential to be neuroprotective, uh, through all the different mechanisms. 675 00:41:56,620 --> 00:42:01,240 It gets really complex really quickly. But as a, a blob, uh, 676 00:42:01,600 --> 00:42:05,320 cannabis resin, I think we, we've got a few, few things we can discuss. 677 00:42:06,460 --> 00:42:11,360 Um, it seems to me like this would be very, uh, since there are so many, uh, 678 00:42:11,360 --> 00:42:13,200 participants in neuroprotection, 679 00:42:13,360 --> 00:42:16,680 I would think that it would be hard to research them because you gotta tease 'em 680 00:42:16,680 --> 00:42:21,520 apart and they're all working together in very high numbers and symbiotically. 681 00:42:23,280 --> 00:42:23,840 Yeah. 682 00:42:23,840 --> 00:42:28,690 Yeah. Um, alright, so, so when I asked you, you know, 683 00:42:29,320 --> 00:42:31,930 what are they protecting us from, essentially the, 684 00:42:31,990 --> 00:42:35,770 the first two you mentioned was inflammation and, and free radicals. 685 00:42:35,790 --> 00:42:37,690 Is that just like a huge bucket that, 686 00:42:37,880 --> 00:42:41,130 that holds just about everything or are there a couple others that you could 687 00:42:41,140 --> 00:42:45,290 check off for us? Uh. 688 00:42:45,920 --> 00:42:49,650 Well, we can, maybe if you want to talk a little bit about the mechanisms, 689 00:42:49,710 --> 00:42:54,690 but if we were to look into diseases and what type of proteins might 690 00:42:54,690 --> 00:42:59,210 be causing these inflammatory responses and free radicals, 691 00:42:59,950 --> 00:43:04,330 we could look at, uh, for Alzheimer's disease, amyloid, 692 00:43:04,520 --> 00:43:05,450 beta and tau, 693 00:43:05,740 --> 00:43:10,570 which are two proteins that are forming to create inflammation and free 694 00:43:10,570 --> 00:43:13,890 radicals on the inside the cell, 695 00:43:13,910 --> 00:43:18,170 and also inflammation outside the cell and how C B D can play a role 696 00:43:18,750 --> 00:43:21,730 in reducing inflammation and also, uh, 697 00:43:21,730 --> 00:43:26,530 helping with the maybe even endogenous ability, 698 00:43:26,950 --> 00:43:31,650 so the cell's ability to, uh, deal with these free radicals. 699 00:43:32,150 --> 00:43:37,140 Mm-hmm. , um, these, um, the, 700 00:43:37,140 --> 00:43:40,440 the, the, ah, I don't like putting all, 701 00:43:40,520 --> 00:43:43,920 I don't like putting like Alzheimer's and dementia all in the, 702 00:43:43,920 --> 00:43:46,760 in the same basket, and I don't, I don't like to generalize them, 703 00:43:46,760 --> 00:43:50,640 so I guess I'll just stick with Alzheimer's. Um, um, 704 00:43:51,540 --> 00:43:56,040 do we understand, um, the functioning at this point of, 705 00:43:56,180 --> 00:44:00,800 of Alzheimer's in the brain where we are able to get down to the specific 706 00:44:01,050 --> 00:44:04,360 mechanisms that, um, uh, of, 707 00:44:04,380 --> 00:44:08,600 of cannabis neuroprotection that's working? You kind of, you gave me a little, 708 00:44:08,840 --> 00:44:11,600 a little bait there with the mechanism and, and honestly, if, 709 00:44:11,660 --> 00:44:15,680 if you can make it, um, understandable to some degree to a lay person, 710 00:44:15,740 --> 00:44:16,640 I'd like you to go through that. 711 00:44:18,560 --> 00:44:19,230 Yeah. 712 00:44:19,230 --> 00:44:23,650 So if we looked at a protein in the brain that forms 713 00:44:23,680 --> 00:44:28,490 naturally, amyloid beta is a naturally forming protein. It, it, 714 00:44:28,800 --> 00:44:31,250 it's just part of everybody. 715 00:44:31,440 --> 00:44:33,880 Everybody's got some of that floating around in the brain. 716 00:44:35,470 --> 00:44:39,560 What happens is it begins to aggregate and when it aggregate, 717 00:44:39,700 --> 00:44:42,400 it sort of clumps together and forms a plaque. 718 00:44:42,740 --> 00:44:45,640 And when too many of these plaques build up inside the brain, 719 00:44:46,430 --> 00:44:48,840 they begin to form inflammation. 720 00:44:49,550 --> 00:44:53,840 They also begin to irritate the cells and they form reactive oxygen species 721 00:44:54,330 --> 00:44:58,920 lipid peroxidation. Now, one mechanism that, 722 00:44:59,140 --> 00:45:04,120 uh, C B D and some of the other terpenes can do is actually to 723 00:45:06,200 --> 00:45:09,570 stop the aggregation of this protein. Therefore, 724 00:45:10,070 --> 00:45:14,730 it will reduce the cascade of negative effects from this 725 00:45:14,800 --> 00:45:19,290 protein by just becoming an anti atory agent. 726 00:45:21,080 --> 00:45:23,410 Therefore, protecting the cells from cell death, 727 00:45:23,410 --> 00:45:25,530 either from an inflammatory cascade 728 00:45:27,030 --> 00:45:31,930 of chemicals or from an overproduction of reactive oxygen 729 00:45:31,930 --> 00:45:34,290 species, it all leads to cell death. 730 00:45:35,950 --> 00:45:39,050 All right. Um, I've got two kind of corollary questions. 731 00:45:39,470 --> 00:45:42,450 The first corollary question is, um, if, 732 00:45:42,950 --> 00:45:46,130 if inflammation is, um, 733 00:45:47,350 --> 00:45:51,810 trying to inhibit, um, neurogenesis and by using cannabis, 734 00:45:51,820 --> 00:45:56,770 we're decreasing the inflammation and, and helping the neurogenesis, 735 00:45:57,510 --> 00:45:57,930 you know, 736 00:45:57,930 --> 00:46:01,210 I talk with so many patients that have got all these different inflammatory 737 00:46:01,290 --> 00:46:02,890 diseases from, you know, 738 00:46:03,180 --> 00:46:07,770 autoimmune and rheumatoid arthritis and, you know, just like, you know, just, 739 00:46:07,770 --> 00:46:10,890 just like there's the whole list of these inflammatory diseases that are so 740 00:46:11,430 --> 00:46:14,170 common in our modern world. Uh, um, 741 00:46:15,720 --> 00:46:20,690 will this body inflammation also be likely presenting in the brain? 742 00:46:20,950 --> 00:46:23,250 And, and, you know, the, 743 00:46:23,270 --> 00:46:27,330 the rheumatoid arthritis patient with all this body inflammation and all their 744 00:46:27,330 --> 00:46:31,730 joints is probably also having a difficult time, uh, 745 00:46:31,730 --> 00:46:32,890 with neurogenesis, 746 00:46:33,070 --> 00:46:36,410 but that's just not the part that's usually talked about in their disease. 747 00:46:38,140 --> 00:46:40,430 Yeah, it's a really complex one. Uh, yeah, 748 00:46:40,510 --> 00:46:45,310 I would say that if there are targets inside certain cell families or 749 00:46:45,610 --> 00:46:46,290 on the cell, 750 00:46:46,290 --> 00:46:51,230 inside cell families that are the same similar targets in the 751 00:46:51,230 --> 00:46:56,150 brain cells, then we could say like one target that c bds pretty good at, 752 00:46:56,770 --> 00:47:01,350 uh, activating is the P P A R gamma 753 00:47:01,970 --> 00:47:05,110 uh, receptor, which once it's hit, 754 00:47:05,490 --> 00:47:10,350 it sort of blocks this cascade to pro-inflammatory molecules such 755 00:47:10,350 --> 00:47:14,630 as, you know, like the tumor necrosis factor alpha, the interleukin one, 756 00:47:14,970 --> 00:47:19,110 and then all these other cytokine released, which, you know, this does, 757 00:47:19,170 --> 00:47:20,910 it is fueled by amyloid beta, 758 00:47:20,910 --> 00:47:24,750 but there are other factors that go on in different sort of areas of the body 759 00:47:25,080 --> 00:47:28,830 where this could be a target for C B D to reduce this inflammation. 760 00:47:29,540 --> 00:47:33,400 Um, you know, for a lot of lay folks, um, you know, 761 00:47:33,780 --> 00:47:36,960 neuroprotection and neuroplasticity, uh, 762 00:47:36,960 --> 00:47:39,640 for a lot of folks are like synonymous and they kind of use them 763 00:47:39,640 --> 00:47:44,560 interchangeably. Um, uh, how much truth is there to that and, 764 00:47:44,560 --> 00:47:48,120 and if they're not the same thing, which I'm assuming they're not, um, 765 00:47:48,170 --> 00:47:50,760 would you explain what neuroplasticity is? 766 00:47:52,360 --> 00:47:57,080 I can give it my best attempt with saying neuroplasticity is the 767 00:47:57,670 --> 00:48:02,640 ability for the brain to communicate in a simple way. Mm-hmm. . 768 00:48:02,640 --> 00:48:07,000 So it's like, uh, uh, this 769 00:48:08,910 --> 00:48:12,830 communication that we're using right now on the phone, if it gets real staticky, 770 00:48:12,860 --> 00:48:16,310 then it's not very plastic. We're not making connections, 771 00:48:16,310 --> 00:48:18,590 we're not communicating. But if it's clear, 772 00:48:18,780 --> 00:48:22,630 then we're having some good neuroplasticity, which would involve function, 773 00:48:23,200 --> 00:48:25,870 would involve, uh, communication. 774 00:48:26,050 --> 00:48:30,670 It would also involve being able to, you know, 775 00:48:30,790 --> 00:48:34,470 'cause even cells can sort of change their shape to allow them to 776 00:48:36,470 --> 00:48:37,160 communicate better, 777 00:48:37,160 --> 00:48:41,870 which might even fall in the form of resilience or neuroplasticity. 778 00:48:41,890 --> 00:48:43,270 So I'd say it's function, 779 00:48:43,870 --> 00:48:48,390 communication and adaption to different things that we learn 780 00:48:48,730 --> 00:48:50,150 or, you know, 781 00:48:52,600 --> 00:48:56,240 I guess we're still trying to map that one out, but if the cell is healthy, 782 00:48:56,470 --> 00:49:01,200 it's gonna function better, therefore ob more plastic or neuro neuroplastic. 783 00:49:01,770 --> 00:49:03,120 Using layman's terms. 784 00:49:03,360 --> 00:49:08,080 I can see how cannabidiol would add to neuroplasticity since we 785 00:49:08,130 --> 00:49:11,200 often think of C B D as a signaling molecule, 786 00:49:11,660 --> 00:49:16,640 and if at the heart of neuroplasticity is community communication and the 787 00:49:16,640 --> 00:49:19,120 ability to communicate, you know, throughout the cells, 788 00:49:19,500 --> 00:49:24,440 it would seem that adding more C B D, um, would be able to, 789 00:49:24,820 --> 00:49:26,360 you know, encourage, uh, 790 00:49:26,830 --> 00:49:31,440 more and more rapid communication between the different, 791 00:49:31,660 --> 00:49:33,600 um, you know, neurons. Yeah. 792 00:49:34,150 --> 00:49:35,280 Yeah. And one, uh, 793 00:49:35,680 --> 00:49:40,480 molecule in particular that I find interesting with CBDs abilities 794 00:49:40,980 --> 00:49:43,880 is to enhance acetylcholine, 795 00:49:43,970 --> 00:49:48,040 which is sort of like the master communicator between, you know, 796 00:49:48,350 --> 00:49:52,200 neurons and there's a particular enzyme acetyl colter raise 797 00:49:53,270 --> 00:49:56,800 that breaks down acetylcholine. And, um, 798 00:49:57,060 --> 00:50:00,720 if we can block acetyl colter raise to a certain extent, 799 00:50:00,900 --> 00:50:05,240 we can enhance the ability of acetylcholine in its 800 00:50:05,600 --> 00:50:07,120 communication between cell and cell, 801 00:50:07,120 --> 00:50:11,160 which is actually some of the ad therapeutics drugs that are out there. 802 00:50:11,420 --> 00:50:14,120 Do so, and from that functional standpoint, 803 00:50:14,280 --> 00:50:19,120 C B D does in enhance the communication or the neuroplasticity 804 00:50:19,350 --> 00:50:20,280 between the cells. 805 00:50:21,260 --> 00:50:25,680 So if, if we're wanting to use cannabinoids to increase our neuroplasticity, 806 00:50:26,020 --> 00:50:28,400 can you give me a couple of examples of, 807 00:50:28,780 --> 00:50:31,790 of things that either a, 808 00:50:31,790 --> 00:50:35,710 things that we might do that might decrease the neuroplasticity, 809 00:50:35,970 --> 00:50:38,950 or if you wanna keep it on the molecular level, the, 810 00:50:39,090 --> 00:50:42,630 the kinds of things that can inhibit our neuroplasticity? 811 00:50:44,900 --> 00:50:45,520 Uh, well, 812 00:50:45,520 --> 00:50:49,600 there's lots of toxins that will get in there and block the communication. I, 813 00:50:49,920 --> 00:50:54,120 I think if you overdue t h c, 814 00:50:54,340 --> 00:50:58,040 it can somewhat crowd the communication line or just, you know, 815 00:50:58,510 --> 00:51:01,200 stop it wanting to function altogether, uh, 816 00:51:01,200 --> 00:51:05,480 which has its benefit and, and some degree. Uh, 817 00:51:05,780 --> 00:51:07,840 but if we wanted to enhance the communication, 818 00:51:08,830 --> 00:51:11,920 then we gotta make these cells functional and as healthy as possible. 819 00:51:12,140 --> 00:51:17,000 So there's a lot of factors that go into how to enhance this communication. 820 00:51:17,820 --> 00:51:21,720 So it sounds like we're talking about like, you know, um, you know, 821 00:51:21,720 --> 00:51:24,720 everything en environmental toxins, um, you know, 822 00:51:25,040 --> 00:51:30,040 probably a lot of different types of pharmaceuticals, um, alcohol, um, you know, 823 00:51:30,040 --> 00:51:32,520 huffing, acetone, you know, there's probably lots, 824 00:51:32,580 --> 00:51:35,400 all all of these things probably ha uh, 825 00:51:36,490 --> 00:51:41,240 would impact neuroplasticity in different ways. So that we're kind of, 826 00:51:41,410 --> 00:51:44,360 we're kind of back to the place where we were when first set we're, 827 00:51:44,360 --> 00:51:46,200 where we're talking about, you know, 828 00:51:46,430 --> 00:51:48,800 good living helps all of this stuff we're talking about. 829 00:51:49,930 --> 00:51:50,990 For sure. Mm-hmm. 830 00:51:51,030 --> 00:51:54,230 . All right. So, um, let's, 831 00:51:54,230 --> 00:51:58,830 let's now focus on the impacts of a brain, um, without neurogenesis, 832 00:51:58,830 --> 00:52:03,510 which will kind of set us up for the third set, talking about, um, um, you know, 833 00:52:03,700 --> 00:52:07,070 some of these ways that, that we can help patients. So, um, 834 00:52:08,540 --> 00:52:11,070 I've always just assumed that, um, 835 00:52:11,880 --> 00:52:15,670 decreasing neurogenesis is generally a part of aging, 836 00:52:16,370 --> 00:52:18,550 and based on what we just said, 837 00:52:19,170 --> 00:52:22,870 if we're doing more things that age us, like, you know, 838 00:52:22,870 --> 00:52:25,990 smoking tobacco and drinking and, and you know, 839 00:52:26,220 --> 00:52:29,070 poor sleep and all these things that, that, um, 840 00:52:29,800 --> 00:52:34,550 these will all impede neurogenesis, um, over time. Um, 841 00:52:34,930 --> 00:52:36,630 is, is, is that true or is, 842 00:52:36,650 --> 00:52:40,390 is there a particular mechanism at the heart of it that I'm missing? 843 00:52:41,670 --> 00:52:42,570 No, that in general, 844 00:52:42,870 --> 00:52:46,970 I'm going to agree with you that just aging itself will 845 00:52:47,920 --> 00:52:51,490 promote the degeneration of, uh, 846 00:52:52,050 --> 00:52:56,970 neuronal cells and inhibit the ability for neurogenesis 847 00:52:56,990 --> 00:53:01,170 to occur. But if we looked at, say, a toxin, 848 00:53:01,170 --> 00:53:03,290 like even alcohol, 849 00:53:04,920 --> 00:53:07,690 CBDs comes in there and we've seen that it can, one, 850 00:53:07,690 --> 00:53:12,450 reduce your cravings to take it, and two can also protect, 851 00:53:12,790 --> 00:53:13,070 uh, 852 00:53:13,070 --> 00:53:17,930 the liver from inflammation and even brain cells from oxidative stress. 853 00:53:19,070 --> 00:53:22,720 Uh, so, you know, 854 00:53:22,740 --> 00:53:25,840 to some extent there is some things we can't avoid, 855 00:53:25,980 --> 00:53:29,600 but if CVDs coming around and, you know, showing us that, hey, 856 00:53:30,070 --> 00:53:34,040 this can show some neuroprotection alongside of a neurotoxin, 857 00:53:34,990 --> 00:53:39,280 then, uh, we've, we have a, at least some defense, 858 00:53:39,900 --> 00:53:44,840 uh, that we can use outside of just, you know, 859 00:53:45,030 --> 00:53:45,863 lifestyle. 860 00:53:46,610 --> 00:53:50,120 Right on. Great. Well, I don't think we need to, um, to, 861 00:53:50,220 --> 00:53:54,680 to bang on the eat hold foods, get exercise live, well drum anymore. 862 00:53:55,060 --> 00:53:58,640 Um, I think we're pretty much set. So, so dear listener, um, stay with us. 863 00:53:58,650 --> 00:54:03,040 We're gonna take our, uh, second short break, but when we come back on, uh, 864 00:54:03,500 --> 00:54:07,040 for set three, we're gonna talk, uh, specifically, um, 865 00:54:07,040 --> 00:54:11,840 about Alzheimer's and dementia and also longevity. So if, 866 00:54:11,900 --> 00:54:14,120 uh, if you, you know, if you're presently pretty healthy, 867 00:54:14,260 --> 00:54:16,560 but you just wanna stay that way, um, uh, 868 00:54:16,560 --> 00:54:20,120 stick around to learn more about that as well. So, uh, 869 00:54:20,120 --> 00:54:23,680 you are listening to Shaping Fire and my guest today is Phytocannabinoid 870 00:54:23,920 --> 00:54:25,080 researcher state and laws. 871 00:54:27,750 --> 00:54:31,620 There are so many seed banks nowadays that you really have options and who to 872 00:54:31,620 --> 00:54:34,780 choose. Not only that, if you pick the wrong seed bank, 873 00:54:34,920 --> 00:54:36,820 you could be in for a really sketchy ride. 874 00:54:37,320 --> 00:54:42,180 And that's only one of the reasons I recommend Gas Lamp Seeds to my friends 875 00:54:42,180 --> 00:54:44,180 and listeners who are looking for a seed bank. 876 00:54:44,760 --> 00:54:48,540 You probably already know gas lamp seeds as Hera Genetics, 877 00:54:49,010 --> 00:54:51,780 Hera recently changed their name to Gas lamp Seeds. 878 00:54:52,640 --> 00:54:57,340 Gas Lamp Seeds is not just another Seed Bank Gas lamp is a female operated 879 00:54:57,660 --> 00:55:02,020 boutique cannabis genetics provider that only sells thoughtfully curated seeds 880 00:55:02,090 --> 00:55:04,020 from the top names in cannabis breeding. 881 00:55:04,610 --> 00:55:08,100 With over 60 breeders and over a thousand strains to choose from, 882 00:55:08,360 --> 00:55:10,140 you will certainly find something you'll love. 883 00:55:10,920 --> 00:55:12,980 Gas lamp Seeds has something for everyone. 884 00:55:13,130 --> 00:55:16,100 With over 650 feminized strains, 885 00:55:16,390 --> 00:55:20,780 300 regular varieties, and over 200 auto flowers to choose from. 886 00:55:21,390 --> 00:55:25,820 Names you know you can trust, like compound genetics, Humboldt Seed Company, 887 00:55:26,270 --> 00:55:30,980 night Owl in-house, fast buds, no automatics and ethos. 888 00:55:31,720 --> 00:55:35,500 And we both know that there are other seed banks who will take your money but 889 00:55:35,500 --> 00:55:36,740 have no customer service. 890 00:55:37,700 --> 00:55:41,940 I invited Gas Lamp to advertise on shaping fire after hearing so many good 891 00:55:41,940 --> 00:55:43,420 stories about them from my friends, 892 00:55:44,130 --> 00:55:47,980 they have a plus customer service with lightning fast response times. 893 00:55:48,880 --> 00:55:49,713 In most cases, 894 00:55:49,720 --> 00:55:52,900 Helene and Kaitlyn will get your order out the same day you place it. 895 00:55:53,690 --> 00:55:57,660 Most seed banks are simply not this organized or interested in getting your 896 00:55:57,710 --> 00:56:01,380 seeds to you so fast, but gas lamp seeds cares. 897 00:56:01,880 --> 00:56:06,140 You even get free seeds with every order. 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Instagram has follow-up posts to shaping fire episodes, 942 00:58:55,680 --> 00:58:59,850 growing and processing best practices, product trials, and of course, 943 00:59:00,490 --> 00:59:01,323 gorgeous flower photos. 944 00:59:01,750 --> 00:59:05,330 The Shang Lo Instagram follows My travels on cannabis garden tours, 945 00:59:05,590 --> 00:59:07,810 my successes and failures in my own garden, 946 00:59:08,570 --> 00:59:12,810 insights and best practices from personal grows everywhere and always gorgeous 947 00:59:12,830 --> 00:59:15,210 flower photos on both profiles. 948 00:59:15,230 --> 00:59:18,410 The emphasis is on sharing what I've learned in a way that you can replicate it 949 00:59:18,410 --> 00:59:22,720 in your own garden, your own hash lab, or for your own canna Apathic health. 950 00:59:23,140 --> 00:59:28,040 So I encourage you to follow at Shaping Fire and at Shang los and join our 951 00:59:28,040 --> 00:59:32,280 online community on Instagram. Welcome back. You are listening to Shaping Fire. 952 00:59:32,440 --> 00:59:33,920 I am your host Shang Los, 953 00:59:34,100 --> 00:59:36,960 and my guest today is Phyto Cannabinoid Researcher State and Laws. 954 00:59:37,740 --> 00:59:41,360 So here we are in the big third set. So Staton, you know, 955 00:59:42,100 --> 00:59:46,400 at the end of last set we were talking about how aging 956 00:59:47,060 --> 00:59:50,000 and, you know, depending on how fast we're aging, 957 00:59:50,000 --> 00:59:53,760 because of how much we're riding our body, hard and abusing it, you know, 958 00:59:54,060 --> 00:59:58,760 all of those things will decrease our neurogenesis and, 959 00:59:59,340 --> 01:00:00,000 uh, C b, 960 01:00:00,000 --> 01:00:04,400 D and t H C and some other cannabinoids can help support neurogenesis. 961 01:00:05,220 --> 01:00:09,600 But, um, you know, there's only so much can be done if, if, you know, 962 01:00:09,610 --> 01:00:11,560 we're our body is aging right, 963 01:00:11,820 --> 01:00:14,400 either on its own or because we've been living hard. 964 01:00:15,020 --> 01:00:19,600 So would you explain a bit about, um, uh, 965 01:00:20,220 --> 01:00:24,640 you know, how this lack of neurogenesis, um, 966 01:00:25,030 --> 01:00:28,320 well, actually before we go to that, I want to ask a, a definitional question. 967 01:00:28,660 --> 01:00:31,120 You know, so, so often people are, 968 01:00:31,120 --> 01:00:32,840 they'll say something and then they'll just say, 969 01:00:32,950 --> 01:00:37,120 Alzheimer's disease and dementia. Like, like they'll group them together, 970 01:00:37,500 --> 01:00:40,960 but they won't put them in the same bucket. So if you could, 971 01:00:41,290 --> 01:00:44,640 would you just give us a brief understanding of what's different between 972 01:00:44,670 --> 01:00:47,440 Alzheimer's and dementia? Because as a lay person, 973 01:00:47,550 --> 01:00:50,920 they kind of sound the same to me, but people always talk about them separately. 974 01:00:50,920 --> 01:00:53,240 So I'm guessing there's a difference that I just don't know. 975 01:00:56,250 --> 01:00:57,000 Yeah. 976 01:00:57,000 --> 01:01:01,740 So dementia can be categorized into different 977 01:01:01,830 --> 01:01:06,500 forms, but Alzheimer's disease is the most common form of dementia. 978 01:01:07,240 --> 01:01:12,020 So if you were to say dementia is where these protein aggregates 979 01:01:12,020 --> 01:01:15,220 start to form and cause memory loss or 980 01:01:17,100 --> 01:01:17,933 body 981 01:01:18,950 --> 01:01:23,800 dysfunction and how it operates as it 982 01:01:24,080 --> 01:01:24,913 progresses, 983 01:01:25,550 --> 01:01:30,280 then it might form into a specific type of disease 984 01:01:30,470 --> 01:01:32,720 from dementia called Alzheimer's disease. 985 01:01:32,800 --> 01:01:35,800 Alzheimer's disease is kind of the end of the road of a form of dementia. 986 01:01:35,800 --> 01:01:37,600 It's the most common form. Mm-hmm. . 987 01:01:39,180 --> 01:01:43,720 So, um, we talked a little bit about the mechanics, uh, last, uh, set about, 988 01:01:44,060 --> 01:01:48,880 you know, precursors to dementia and then Alzheimer's and you know, 989 01:01:48,940 --> 01:01:53,560 how it, how it progresses. Um, uh, and, and now you're talking about, you know, 990 01:01:53,700 --> 01:01:58,400 the d the different, um, uh, symptoms of the ailments, you know, um, um, 991 01:01:58,540 --> 01:02:02,680 uh, forgetting things and um, uh, uh, 992 01:02:03,100 --> 01:02:05,000 the changing relationship with one's body. 993 01:02:05,420 --> 01:02:08,440 Can you just pick one or two of those and, um, 994 01:02:08,980 --> 01:02:13,680 and explain to us the mechanics of what's going on with Alzheimer's to cause 995 01:02:13,780 --> 01:02:15,080 the symptoms? So, 996 01:02:15,260 --> 01:02:19,520 so moving from what causes Alzheimer's two, 997 01:02:20,070 --> 01:02:21,720 what does Alzheimer's cause? 998 01:02:25,530 --> 01:02:26,330 Okay, well, 999 01:02:26,330 --> 01:02:31,260 I'll go with just the big definition and filter it 1000 01:02:31,260 --> 01:02:33,820 down to what it, what happens mm-hmm. . 1001 01:02:33,820 --> 01:02:38,660 So if we have these natural amyloid beta proteins in the 1002 01:02:38,660 --> 01:02:40,660 brain and they form aggregates, 1003 01:02:41,530 --> 01:02:46,220 then at the same sort of time inside the cell are these neuro ular tangles, 1004 01:02:46,910 --> 01:02:50,580 which consists of the hyper phospholate tau protein. 1005 01:02:51,680 --> 01:02:53,340 Now this is partnered, uh, 1006 01:02:53,490 --> 01:02:58,100 this deteriorate deleterious pro part process is partnered with 1007 01:02:58,300 --> 01:03:01,340 reactive oxygen species, reactive nitrogen species, 1008 01:03:01,350 --> 01:03:05,500 which is your oxidative stress, mitochondria damage, uh, 1009 01:03:05,980 --> 01:03:08,300 redu that's inside the cell, outside the cell. 1010 01:03:08,660 --> 01:03:10,580 Reduction of acetylcholine levels, 1011 01:03:10,590 --> 01:03:14,300 which we're talking about plays a role in the neuroplasticity or the 1012 01:03:14,860 --> 01:03:15,693 communication. 1013 01:03:16,170 --> 01:03:20,180 Then these networks begin to lose their connections. 1014 01:03:20,200 --> 01:03:25,180 So misplaced networks among neurons inside the hippocampus, we've seen that the, 1015 01:03:25,240 --> 01:03:29,940 it actually shrinks and we get this chronic neuroinflammation 1016 01:03:29,940 --> 01:03:34,380 causing memory loss and cognitive impairment. Eventually, we can't even, 1017 01:03:34,880 --> 01:03:37,580 you know, take care of ourselves in the end. 1018 01:03:39,550 --> 01:03:44,210 Um, this idea of misplaced networks, um, 1019 01:03:44,990 --> 01:03:46,410 that's a really, um, 1020 01:03:46,870 --> 01:03:51,450 that's a very efficient phrase because it really does describe what I experience 1021 01:03:51,450 --> 01:03:55,890 when interacting with, um, Alzheimer's patients. 1022 01:03:56,310 --> 01:03:56,750 Um, 1023 01:03:56,750 --> 01:04:00,330 and also there's something about that phrase that captures some of the sadness 1024 01:04:00,510 --> 01:04:01,343 of it too. 1025 01:04:03,970 --> 01:04:06,820 Yeah, it's, uh, it can, you know, 1026 01:04:07,000 --> 01:04:11,260 really take you down a road that affects you and your family members. 1027 01:04:12,560 --> 01:04:13,740 So, alright, so, 1028 01:04:13,840 --> 01:04:18,020 so this brings us to a place where we know neurogenesis and 1029 01:04:18,020 --> 01:04:21,940 neuroprotection are essential for our brain to function properly over the long 1030 01:04:21,940 --> 01:04:24,700 term. And when it slows down with age, 1031 01:04:25,120 --> 01:04:28,900 it leaves us open to debilitate debilitating brain issues. 1032 01:04:29,680 --> 01:04:34,540 And we also know from first set that the cannabis compound, 1033 01:04:34,540 --> 01:04:36,540 that the cannabis components, um, 1034 01:04:36,920 --> 01:04:40,300 can support neurogenesis and neuroprotection. So, 1035 01:04:40,520 --> 01:04:44,580 so obviously we've made the case like take some cannabis, right? So, so, um, 1036 01:04:45,000 --> 01:04:46,740 so I'm gonna ask you about, um, 1037 01:04:47,050 --> 01:04:51,140 some cannabis protocols that you think that might make sense for someone 1038 01:04:52,120 --> 01:04:56,900 who, who still has brain health and wants to keep it. And then, 1039 01:04:57,120 --> 01:05:01,060 and then I'll kind of reapproach the question again for somebody who's already 1040 01:05:01,380 --> 01:05:05,540 experiencing, um, you know, problems. So, 1041 01:05:05,560 --> 01:05:08,260 so I guess this first one, let's, let's throw this kind of in the, 1042 01:05:08,520 --> 01:05:11,340 in the longevity, uh, bucket. Um, 1043 01:05:11,370 --> 01:05:14,540 I've been doing a lot of thinking about cannabinoids as a, 1044 01:05:14,600 --> 01:05:18,920 as a longevity tool and, and it really seems to work. So, so, 1045 01:05:18,980 --> 01:05:20,200 so let's say that like, you know, 1046 01:05:20,200 --> 01:05:23,680 even though we know that everybody's got something wrong with them, um, well, 1047 01:05:23,680 --> 01:05:26,640 let's say that we're talking about a person who's generally brain healthy and 1048 01:05:26,640 --> 01:05:29,880 they're not, they're not experiencing dementia or Alzheimer's at this point, 1049 01:05:30,300 --> 01:05:34,280 but, but they don't, they don't want to, right? And, and, or, or, 1050 01:05:34,340 --> 01:05:38,280 or maybe they're like me. And, and some of that stuff runs in the family, right? 1051 01:05:38,340 --> 01:05:42,320 So I wanna, I wanna bio protect against it in advance. So, 1052 01:05:42,620 --> 01:05:47,280 so what would you see as, um, a, a, 1053 01:05:47,440 --> 01:05:51,920 a dosing protocol for somebody who is thinking more about, um, 1054 01:05:52,900 --> 01:05:57,720 uh, longevity and, um, and, and, you know, 1055 01:05:57,870 --> 01:05:59,960 long-term health, um, 1056 01:06:00,860 --> 01:06:05,800 before something a brain disease has has shown 1057 01:06:05,820 --> 01:06:06,653 up? 1058 01:06:08,040 --> 01:06:12,100 Um, I guess we've gotta always throw that disclaimer, alert out, yes. 1059 01:06:12,610 --> 01:06:14,460 This is not medical. See your medical doctor. 1060 01:06:14,680 --> 01:06:16,420 Mm-hmm. Or, uh, 1061 01:06:16,880 --> 01:06:21,620 and make sure you see your phys physician before taking a substance 1062 01:06:22,890 --> 01:06:24,420 that is new to your body. 1063 01:06:24,640 --> 01:06:27,340 So, well, thank you for that's put that you beat me to it. Sat out on the table. 1064 01:06:27,340 --> 01:06:29,140 That's usually my job. You got it. Thank you. 1065 01:06:30,380 --> 01:06:31,700 . Um, 1066 01:06:31,800 --> 01:06:35,580 and are we talking all cannabinoids or just c b D? 1067 01:06:35,920 --> 01:06:38,300 Um, well, um, I would like to hear what your, 1068 01:06:38,300 --> 01:06:40,140 your blend would be if you're gonna, if you, you know, 1069 01:06:40,140 --> 01:06:43,820 maybe you're gonna tell me that, um, you know, a a 20 to one of a, 1070 01:06:43,820 --> 01:06:47,580 of a certain potency taken every day or twice a day, um, you know, 1071 01:06:48,120 --> 01:06:49,340 at this point, um, 1072 01:06:49,920 --> 01:06:54,100 you have got all of this various information already preexisting in your head. 1073 01:06:54,520 --> 01:06:55,540 And so if, 1074 01:06:55,560 --> 01:07:00,420 if you were to put together a best practice for a cannabinoid supplement 1075 01:07:00,800 --> 01:07:03,620 to preserve, uh, brain health, what would it look like? 1076 01:07:04,780 --> 01:07:09,540 I would probably start with just c B D personally. Mm-hmm. , 1077 01:07:09,640 --> 01:07:13,580 uh, if you'd never used cannabis, you're like, I've heard cannabis, uh, 1078 01:07:13,800 --> 01:07:17,900 is gonna help my brain as I age now, 1079 01:07:18,700 --> 01:07:23,300 I mean, even we go back 20 years from now, that was the, you know, talking, 1080 01:07:23,760 --> 01:07:27,500 you know, the, the Devil's Tobacco mm-hmm. . And, uh, 1081 01:07:27,880 --> 01:07:31,620 now we're looking at it as a way to preserve our brain. 1082 01:07:31,800 --> 01:07:36,180 So let's start with C B D because it's probably the safest. 1083 01:07:36,800 --> 01:07:40,220 And I would almost have to say that if we're going to even ask this question, 1084 01:07:40,570 --> 01:07:42,580 then we'd probably be concerned 1085 01:07:44,330 --> 01:07:48,590 around the age of 30 to 40 if we're, if we're still healthy, you know, 1086 01:07:48,740 --> 01:07:52,470 this is around about 65 is when dementia like symptoms usually present 1087 01:07:52,470 --> 01:07:52,930 themselves. 1088 01:07:52,930 --> 01:07:57,550 So we're beyond that adolescent phase where T H C is gonna 1089 01:07:58,050 --> 01:08:00,190 be as harmful as what we've experienced. 1090 01:08:00,570 --> 01:08:05,470 And so we're in that phase where either C B D or T H 1091 01:08:05,510 --> 01:08:08,470 C could be helpful. So I would say starting with C B D, 1092 01:08:08,670 --> 01:08:12,950 'cause it can start to maybe help anandamide do its, 1093 01:08:13,490 --> 01:08:16,840 uh, do its thing with the CB one and CB two receptors, 1094 01:08:16,950 --> 01:08:21,440 plus there's some other benefits that come along with C B D. Now, 1095 01:08:22,220 --> 01:08:27,120 if C B D is not effective and you slowly increment 1096 01:08:27,120 --> 01:08:28,560 your dose and you're, you know, 1097 01:08:29,140 --> 01:08:33,000 taking a plus a hundred milligrams a day and still not seeing anything, 1098 01:08:33,830 --> 01:08:37,640 then I would start adding T H C and, and like you're saying, 1099 01:08:37,810 --> 01:08:42,720 maybe starting at that 20 milligrams of C B D to one milligram of 1100 01:08:42,840 --> 01:08:47,400 T H C, and maybe we start, then we go 20 to five, 1101 01:08:47,740 --> 01:08:52,480 20 milligrams of C B D to five milligrams of T H C or maybe even 1102 01:08:52,540 --> 01:08:57,080 go 50 C B D to five T H C. 1103 01:08:57,100 --> 01:09:00,640 But I would slowly increment, especially T H C is, 1104 01:09:00,860 --> 01:09:05,000 and even more specifically if you have an underlying psychiatric condition with 1105 01:09:05,160 --> 01:09:07,560 T H C, because it is quite psychoactive. 1106 01:09:08,540 --> 01:09:12,840 And then finding that that right milligram dosage and, you know, 1107 01:09:14,060 --> 01:09:14,893 uh, uh, 1108 01:09:15,320 --> 01:09:19,520 T H C has its own unique benefits all in its own right. Uh, 1109 01:09:19,670 --> 01:09:24,240 with helping the brain in many different facets outside of what we've 1110 01:09:25,660 --> 01:09:29,920 mapped out pharmacologically, I believe. So start slow, 1111 01:09:30,980 --> 01:09:32,400 see which one works best for you, 1112 01:09:33,380 --> 01:09:37,440 and generally having a higher amount of C B D to T H C. 1113 01:09:38,330 --> 01:09:41,280 Right on. That's great. And, and you know, if, if, 1114 01:09:41,300 --> 01:09:44,200 if you're at home listening to this and you're thinking about putting together, 1115 01:09:44,420 --> 01:09:46,840 you know, a protocol of your own and, you know, 1116 01:09:46,930 --> 01:09:51,880 maybe you are fortunate enough to be in, in a location where you can, you know, 1117 01:09:51,910 --> 01:09:55,040 grow your, you know, high C B D, 1118 01:09:55,830 --> 01:09:57,840 very low T H c, um, you know, 1119 01:09:57,840 --> 01:10:01,840 plant some kind of high C B D hemp plant or something and make your own R S o, 1120 01:10:02,300 --> 01:10:06,960 um, that, that's very fortunate. And, and don't be shy about, 1121 01:10:07,260 --> 01:10:11,640 um, you know, spiking it with C B D isolate because, you know, 1122 01:10:11,660 --> 01:10:15,760 you can get really high quality C B D isolate out there right now. You know, 1123 01:10:15,760 --> 01:10:19,280 you gotta shop around, you know, fi you know, find, find somebody who, 1124 01:10:19,540 --> 01:10:22,320 who stands by their cleanliness and their tests, you know, like, 1125 01:10:22,320 --> 01:10:26,160 like a future compounds or somebody. And, um, and then, 1126 01:10:26,180 --> 01:10:31,160 and then don't be shy to spike with that to get up to the, 1127 01:10:31,780 --> 01:10:35,320 the C B D numbers that you're looking for. Um, 1128 01:10:35,710 --> 01:10:37,120 because for, 1129 01:10:37,180 --> 01:10:42,120 for most folks growing your own high C B D hemp plants and processing 1130 01:10:42,120 --> 01:10:46,760 it all, um, is just not going to provide you with, 1131 01:10:46,860 --> 01:10:51,400 you know, a hundred milligrams of C B D A day plus T H c. It's, you know, 1132 01:10:51,460 --> 01:10:54,000 you know, if you've got a big farm like, you know, may maybe, 1133 01:10:54,010 --> 01:10:57,200 maybe you're that much of a baller, but for most people, that's not the case. 1134 01:10:57,980 --> 01:11:01,840 And um, and you know, I used to talk trash about this approach, but, you know, 1135 01:11:01,880 --> 01:11:04,800 I think that part of what's important is that we all remain active learners, 1136 01:11:04,850 --> 01:11:09,160 right? And, and while I would love there to be, um, so much, 1137 01:11:09,580 --> 01:11:12,880 you know, c b D resin available to everyone at cheap prices that, 1138 01:11:13,030 --> 01:11:17,720 that we could only use that well, you know, when it comes to our health, um, 1139 01:11:18,060 --> 01:11:22,760 you know, sometimes, sometimes we have to do it, um, in the way that works. Um, 1140 01:11:23,020 --> 01:11:26,720 not, not the way that we necessarily want it to be. So, so anyway, um, 1141 01:11:27,080 --> 01:11:31,920 I just share that because I had to turn a corner about using isolate for 1142 01:11:31,920 --> 01:11:34,160 some applications and, and, um, 1143 01:11:34,260 --> 01:11:37,360 it wouldn't surprise me if some of you were the same way. So, so there's that. 1144 01:11:37,360 --> 01:11:41,300 Alright, so, um, so, so now that we've got this, 1145 01:11:41,560 --> 01:11:43,540 so thank you for this protocol. This was, this was a, 1146 01:11:43,540 --> 01:11:47,580 this was exactly the level of specificity that I was looking for staton. So, 1147 01:11:48,080 --> 01:11:52,780 so let's talk about a, um, a, a a different protocol because now, 1148 01:11:53,160 --> 01:11:54,620 and, and who knows, it might be, 1149 01:11:54,720 --> 01:11:56,860 it might end up being the same protocol for you, but, 1150 01:11:57,000 --> 01:12:01,060 but now we're talking about somebody who is an Alzheimer's patient 1151 01:12:01,960 --> 01:12:03,540 and you know, they've, 1152 01:12:03,540 --> 01:12:06,900 they've already been talking to their family that they wanted to try this and 1153 01:12:06,900 --> 01:12:11,420 their family is in support of it, I hope, and everybody's working together. 1154 01:12:12,160 --> 01:12:12,950 Um, 1155 01:12:12,950 --> 01:12:17,740 would you make any changes to this protocol to somebody who's already 1156 01:12:17,860 --> 01:12:20,740 experiencing symptoms, who's already on this path? 1157 01:12:23,160 --> 01:12:24,460 Not really. Mm-hmm. , um, 1158 01:12:25,100 --> 01:12:28,980 'cause we just don't know how they're gonna respond to either 1159 01:12:30,300 --> 01:12:35,220 compound C B D or T H C or the plethora of other phytochemicals in this 1160 01:12:35,220 --> 01:12:38,540 extract. But, you know, if, 1161 01:12:38,800 --> 01:12:42,580 if one's extremely irritable, then you know, 1162 01:12:42,780 --> 01:12:47,220 a faster acting lower dosage in what you can get your hands on, um, 1163 01:12:47,820 --> 01:12:51,740 approach could be T h C, uh, I mean, because it's, 1164 01:12:51,740 --> 01:12:56,100 it's a tricky question to address this with so many different countries, 1165 01:12:56,410 --> 01:12:58,620 laws states and, uh, 1166 01:12:59,210 --> 01:13:03,460 financial burdens that getting a hold of these compounds will, 1167 01:13:03,530 --> 01:13:06,740 will do for that particular patient. So, I mean, 1168 01:13:08,050 --> 01:13:12,780 it's easy to recommend if, if you're in a state that it's highly available, 1169 01:13:13,360 --> 01:13:17,180 but it's even more difficult to recommend when one can't even afford the 1170 01:13:17,180 --> 01:13:19,540 medication, especially when you're saying, oh, you know, you might, 1171 01:13:19,720 --> 01:13:24,380 you need to be taking around a hundred milligrams of C B D to get any sort of 1172 01:13:24,380 --> 01:13:27,300 effect from it when, you know, like here in Australia, 1173 01:13:27,480 --> 01:13:30,380 the average milligram is about 10 cents, 1174 01:13:30,400 --> 01:13:35,220 so you're looking at a hundred dollars a day for a medication that might work. 1175 01:13:35,640 --> 01:13:37,940 Versus if you can get your hands on, you know, 1176 01:13:37,980 --> 01:13:41,260 a hundred milligrams A T H C and divide that between 10 days, 1177 01:13:41,320 --> 01:13:43,780 you might be getting more, uh, 1178 01:13:44,690 --> 01:13:49,300 therapeutic targets ticked by a less expensive, 1179 01:13:50,640 --> 01:13:53,380 Uh, protocol. So once again, 1180 01:13:53,680 --> 01:13:57,900 con consult your medical doctor first, and depending on where you live, it, it, 1181 01:13:57,960 --> 01:14:02,940 it could somewhat dictate this protocol. So start slow 1182 01:14:04,640 --> 01:14:08,540 CCB d's a little bit safer, but you might work better with T H C, 1183 01:14:08,540 --> 01:14:11,290 especially in later stages of Alzheimer's disease. 1184 01:14:11,650 --> 01:14:16,240 Right on. So, um, what will our goal be, um, 1185 01:14:16,950 --> 01:14:20,840 when the patient or, uh, is taking the, 1186 01:14:21,380 --> 01:14:25,720 the protocol, um, with, with neurogenesis? 1187 01:14:26,060 --> 01:14:28,200 Are we, are we just trying to like, 1188 01:14:28,390 --> 01:14:33,360 hold the line or is it possible that we can improve the patient? 1189 01:14:33,780 --> 01:14:38,680 Um, because, uh, I believe that the, the case is, is that when we, 1190 01:14:38,680 --> 01:14:42,680 when we lose, um, neuron producing, 1191 01:14:43,830 --> 01:14:45,000 when, when, when our, 1192 01:14:45,270 --> 01:14:49,880 when our neurogenesis flags and slows, um, 1193 01:14:50,190 --> 01:14:54,840 it's, it's, it's harder to create new cells that do this. 1194 01:14:54,940 --> 01:14:56,480 And so what we're just trying to do is, 1195 01:14:56,620 --> 01:15:01,520 is hold the line on our ability to produce to 1196 01:15:01,520 --> 01:15:06,360 cause neurogenesis where it is and just decrease the, the sliding of it. 1197 01:15:06,820 --> 01:15:10,800 Um, is that a, is that a correct understanding where, where, 1198 01:15:10,800 --> 01:15:12,320 when we're supporting neurogenesis, 1199 01:15:12,320 --> 01:15:14,600 we're just gonna be supporting where we're not, where we're at, 1200 01:15:14,770 --> 01:15:19,560 we're not necessarily going to be improving it in such a way 1201 01:15:20,250 --> 01:15:25,160 where, um, you know, we could pull somebody back from the grips of Alzheimer's, 1202 01:15:25,160 --> 01:15:25,993 for example? 1203 01:15:27,590 --> 01:15:32,240 Yeah. Uh, if I've always got hope that no matter who you are out there, 1204 01:15:32,300 --> 01:15:36,880 you're going to have the ability to create more brain cells in the right 1205 01:15:36,880 --> 01:15:41,560 environment, let's just say through your lifestyle and through maybe some, uh, 1206 01:15:41,870 --> 01:15:46,600 supplements that includes cannabinoids in the word supplements to 1207 01:15:46,600 --> 01:15:51,520 your protocol. Now, if you've got enough, uh, 1208 01:15:51,990 --> 01:15:56,000 neurons that are functioning correctly in your goal here is to preserve these 1209 01:15:56,030 --> 01:15:57,760 neurons, we're looking at, you know, 1210 01:15:57,760 --> 01:16:00,840 there's some potential for these cannabinoids to help these 1211 01:16:02,310 --> 01:16:06,720 neurons from being affected by whether it is reactive oxygen species, 1212 01:16:06,930 --> 01:16:10,480 these cytokine storms from inflammation, uh, 1213 01:16:10,780 --> 01:16:14,920 and also from acetyl colter raise from breaking down acetylcholine. 1214 01:16:14,980 --> 01:16:17,640 So with these exogenous cannabinoids, 1215 01:16:19,310 --> 01:16:24,120 they might help with our endogenous OIDs such as C B D and anandamide, 1216 01:16:24,260 --> 01:16:28,960 or T H C might go in there and help stimulate some more, uh, 1217 01:16:30,120 --> 01:16:31,800 proliferation of these brain cells, 1218 01:16:32,020 --> 01:16:35,840 and they might protect the ones that we already have and the functioning or the 1219 01:16:35,860 --> 01:16:39,440 neuroplasticity of these brain cells. So yes, 1220 01:16:39,440 --> 01:16:44,160 there's a lot of potential here for this to help on a cellular level, 1221 01:16:44,580 --> 01:16:48,080 and then also on a behavior level of why these, uh, 1222 01:16:49,640 --> 01:16:50,210 symptoms of, 1223 01:16:50,210 --> 01:16:54,160 let's just say Alzheimer's disease could be modified by these chemicals. 1224 01:16:55,410 --> 01:16:59,320 Right on. I follow that. Okay. So let's, let's take, um, 1225 01:16:59,680 --> 01:17:03,680 a step back one more time, uh, as we're wrapping up here. Um, so, 1226 01:17:04,140 --> 01:17:08,800 so we've, we've talked about neurogenesis and neuro protections. We, 1227 01:17:09,020 --> 01:17:10,280 we understand how they work, 1228 01:17:10,700 --> 01:17:15,600 we understand how our ability to do that ourselves worsens with age 1229 01:17:16,060 --> 01:17:19,600 and how we can support that system by using, um, 1230 01:17:20,180 --> 01:17:23,800 by using cannabinoids. Excellent. And, and we've, 1231 01:17:23,970 --> 01:17:27,000 we've looked at the applications for, you know, 1232 01:17:27,000 --> 01:17:29,240 just regular folks who wanna take it as at, 1233 01:17:29,240 --> 01:17:33,960 as a supplement and the very similar protocol for folks who are actually, 1234 01:17:34,220 --> 01:17:34,470 um, 1235 01:17:34,470 --> 01:17:39,000 showing the impacts of the lack of neurogenesis in things like Alzheimer's and 1236 01:17:39,240 --> 01:17:42,360 dementia. So, so with all of that, you know, I, 1237 01:17:42,390 --> 01:17:46,640 I've not really seen it called this, but for me, 1238 01:17:46,710 --> 01:17:49,760 that sounds like we're describing C B D as a nootropic. 1239 01:17:50,140 --> 01:17:52,840 Do you consider c b D be to be a new tropic? 1240 01:17:53,950 --> 01:17:58,080 Yeah. If it can improve cognitive function, then it would be, uh, 1241 01:17:59,250 --> 01:18:02,130 I guess fitting underneath the umbrella of a new tropic. Yeah. 1242 01:18:02,130 --> 01:18:03,650 That's, that's the way I see it too. And, 1243 01:18:03,830 --> 01:18:07,410 and so far I haven't seen it marketed that way, but, um, it's, 1244 01:18:07,410 --> 01:18:11,090 it's interesting 'cause like nootropics are like super hip for the, you know, 1245 01:18:11,190 --> 01:18:13,130 the longevity folks and, 1246 01:18:13,270 --> 01:18:16,530 and C B D is hip with a different group of people, 1247 01:18:16,790 --> 01:18:20,690 but I haven't seen anybody like kind of cross market to both groups and call it 1248 01:18:20,690 --> 01:18:24,090 a nootropic. So, um, what I'd like to, 1249 01:18:24,150 --> 01:18:28,770 to end the episode with, uh, Satan is that I know that, 1250 01:18:29,030 --> 01:18:31,930 uh, you are, um, you know, 1251 01:18:33,550 --> 01:18:37,970 you are a research scientist and you are looking at the specifics of 1252 01:18:38,730 --> 01:18:43,610 neurogenesis, but I also know that, um, you know, 1253 01:18:43,670 --> 01:18:47,770 you are a whole food advocate and you are a healer and, 1254 01:18:48,110 --> 01:18:52,770 and you know, you teach, uh, yoga and, and so you're kind of a, you know, 1255 01:18:52,890 --> 01:18:56,730 a holistically minded researcher who's, you know, doing this, 1256 01:18:56,920 --> 01:19:01,890 this balance between holistic mindset and, 1257 01:19:02,470 --> 01:19:05,210 you know, western medicine, 1258 01:19:05,220 --> 01:19:09,850 which is gotta be a very interesting balancing act for you. Um, but, um, 1259 01:19:09,850 --> 01:19:12,490 because you think about this all the time, um, 1260 01:19:12,710 --> 01:19:15,650 I'd just like to like kind of hand you the mic and have you kind of take us out 1261 01:19:15,870 --> 01:19:18,210 of, um, you know, 1262 01:19:18,600 --> 01:19:23,530 what advice would you give to a human who wants 1263 01:19:23,590 --> 01:19:26,370 to keep their brain, um, 1264 01:19:27,090 --> 01:19:31,810 functioning as far into life as they can with all the benefits of 1265 01:19:31,930 --> 01:19:33,850 neurogenesis and neuroprotection. 1266 01:19:34,220 --> 01:19:38,650 Would you just describe some of the, you know, 1267 01:19:39,640 --> 01:19:44,050 lifestyle attributes that this person may want to consider beyond 1268 01:19:44,590 --> 01:19:49,570 simply taking a C a A A C B D and potentially t h c protocol as 1269 01:19:49,570 --> 01:19:50,403 we've described? 1270 01:19:51,700 --> 01:19:51,940 So, 1271 01:19:51,940 --> 01:19:56,800 are we addressing just the general person that's after mine longevity? 1272 01:19:56,940 --> 01:19:58,880 Are we addressing the Alzheimer's patient? 1273 01:19:59,160 --> 01:20:02,920 I, I would say just a regular person. Um, somebody, somebody who's not, uh, uh, 1274 01:20:03,060 --> 01:20:06,120 you know, not experiencing Alzheimer's yet. Um, just, 1275 01:20:06,120 --> 01:20:09,680 just somebody who wants to, you know, keep their brain healthy. 1276 01:20:09,830 --> 01:20:11,520 This is a general brain health question. 1277 01:20:12,230 --> 01:20:16,160 Okay, well, we'll break it down with, uh, the necessities again. 1278 01:20:16,220 --> 01:20:19,520 So we gotta have oxygen, water, 1279 01:20:20,260 --> 01:20:25,040 and nutrients. So oxygen with, uh, 1280 01:20:25,070 --> 01:20:28,280 breathing, we all can learn to breathe better. 1281 01:20:28,700 --> 01:20:31,940 That's the truth. How we breathe. 1282 01:20:32,760 --> 01:20:35,140 You can get into the anatomy, but simply, 1283 01:20:35,200 --> 01:20:39,940 if there was one word I would say to use and to learn would be UJA breathing, 1284 01:20:40,600 --> 01:20:44,380 and that's a yoga concept. I can get into that if you'd like, 1285 01:20:44,520 --> 01:20:45,540 but basically it's, 1286 01:20:45,690 --> 01:20:48,820 it's a way to take air in and outta the body with more efficiency. 1287 01:20:49,190 --> 01:20:52,260 Maybe just spell it. 'cause we, we won't go into it today, 1288 01:20:52,260 --> 01:20:53,380 but people might wanna look it up. 1289 01:20:53,740 --> 01:20:56,020 I think it's u uh, . 1290 01:20:56,470 --> 01:20:57,340 Sorry, I didn't mean to. 1291 01:20:57,340 --> 01:20:59,060 Do that to you. U j Yeah, it's funny. 1292 01:20:59,540 --> 01:21:02,940 U double j a y i. 1293 01:21:04,070 --> 01:21:04,903 Great. 1294 01:21:05,000 --> 01:21:09,020 Uh, second. So what goes with yoga course is posture, uh, 1295 01:21:09,420 --> 01:21:12,300 learning how to lengthen the spine, keep it straight, 1296 01:21:12,950 --> 01:21:17,820 which supports the blood flow or the nutrients into and out of the brain, 1297 01:21:17,820 --> 01:21:22,620 which the next one would be understanding a little bit about the lymphatic 1298 01:21:22,620 --> 01:21:26,180 system and helping the clearance of too much of these aggregate proteins 1299 01:21:26,180 --> 01:21:28,780 throughout life. So it's also making sure your body, 1300 01:21:28,870 --> 01:21:31,740 let's just call it clean and it, uh, 1301 01:21:32,000 --> 01:21:36,580 is functioning to deliver nutrients, but also to remove or detoxify, 1302 01:21:37,360 --> 01:21:37,750 uh, 1303 01:21:37,750 --> 01:21:42,660 these potential proteins in the brain that are gonna 1304 01:21:42,660 --> 01:21:45,060 mess you up, which is what some of the, you know, 1305 01:21:45,600 --> 01:21:49,540 ad drugs recently come out to do, is actually to remove the proteins. 1306 01:21:50,440 --> 01:21:53,980 So we've got, uh, breath, good clean water, 1307 01:21:55,440 --> 01:21:58,140 um, and which considers, you know, 1308 01:21:58,340 --> 01:22:02,820 some electrolytes if it came from a really clean natural source to make cellular 1309 01:22:02,940 --> 01:22:07,180 hydrated have good posture. And then we get into, 1310 01:22:07,960 --> 01:22:08,793 you know, 1311 01:22:09,110 --> 01:22:13,460 doing our best to not expose ourselves to too many toxins. 1312 01:22:13,480 --> 01:22:17,300 So trying to live in a natural place, trying to get outside. 1313 01:22:17,760 --> 01:22:20,780 And if we looked at what can stimulate neurogenesis, 1314 01:22:21,340 --> 01:22:26,180 I think probably one of the biggest ones is exercise. And, uh, 1315 01:22:26,680 --> 01:22:31,260 you know, exercise produces more of that brain deprived nootropic factor. 1316 01:22:31,800 --> 01:22:35,380 It also creates more endogenous cannabinoids. 1317 01:22:35,760 --> 01:22:39,780 So those two combined together is what helps the cells proliferate. 1318 01:22:40,370 --> 01:22:43,980 Then we can kind of get into that neuroprotection side with, uh, 1319 01:22:44,250 --> 01:22:48,140 some of the protocols of our supplements that will help protect 1320 01:22:49,080 --> 01:22:51,820 us. So when we get into nutrients, I'd probably be looking at, uh, 1321 01:22:51,820 --> 01:22:56,500 your meg omega threes, like E three live, which is a, it's, um, 1322 01:22:57,560 --> 01:23:00,900 uh, an algae that's quite high in D h a and e p a, 1323 01:23:00,900 --> 01:23:02,700 which is known to support brain function. 1324 01:23:03,740 --> 01:23:07,680 I look at making sure the diet is actually extremely high in plant secondary 1325 01:23:07,790 --> 01:23:11,280 metabolites, which those include a big pool of the polyphenols. 1326 01:23:11,280 --> 01:23:12,920 And if we looked at those specifically, 1327 01:23:13,060 --> 01:23:17,840 it would be the flavonoids and even maybe look at getting 1328 01:23:17,980 --> 01:23:22,160 the microbiome up as far as the good bacteria. 1329 01:23:22,420 --> 01:23:27,280 So making sure you take some form of a probiotic 1330 01:23:27,300 --> 01:23:31,760 on a regular basis, whether it's through sauerkraut and the diet, 1331 01:23:31,940 --> 01:23:34,360 or whether it's through, you know, active. 1332 01:23:34,360 --> 01:23:35,360 Yogurt or something. 1333 01:23:35,510 --> 01:23:39,720 Yeah, something like that. And maintaining that with lots of fiber. 1334 01:23:39,780 --> 01:23:43,880 So you got your pre, which is your fiber, you got your pro, 1335 01:23:43,880 --> 01:23:44,920 which is your bacteria, 1336 01:23:45,100 --> 01:23:47,960 and you combine those two together and you get these postbiotics. 1337 01:23:48,140 --> 01:23:52,240 So having a healthy microbiome, these molecule or not molecules, 1338 01:23:52,240 --> 01:23:57,120 these bacteria in your gut will chew up fiber and basically create these 1339 01:23:58,510 --> 01:23:59,330 postbiotics, 1340 01:23:59,330 --> 01:24:02,960 which are nutrients that they create that are good for the brain as well. Like, 1341 01:24:02,980 --> 01:24:03,640 for example, 1342 01:24:03,640 --> 01:24:08,160 a lot of these flavonoids or polyphenols that we consume don't actually get into 1343 01:24:08,160 --> 01:24:10,640 the body till they hit the, the gut bacteria, 1344 01:24:10,700 --> 01:24:14,520 and then they get turned into things that are gonna be good for us. So, 1345 01:24:15,900 --> 01:24:18,760 uh, and then, you know, being positive about life, 1346 01:24:19,080 --> 01:24:23,240 I think cop probably could be the number one thing to have a bit of a passion 1347 01:24:23,340 --> 01:24:26,480 for whatever you're doing in life, whether it's doing the, 1348 01:24:26,540 --> 01:24:29,920 the laundry or the dishes, just, you know, 1349 01:24:29,970 --> 01:24:31,680 being positive through the whole process, 1350 01:24:32,140 --> 01:24:36,240 having a will to live will ultimately expand your lifespan. 1351 01:24:36,260 --> 01:24:40,320 So keeping yourself healthy and feeling as good as possible definitely helps 1352 01:24:40,320 --> 01:24:41,440 with that will to live. 1353 01:24:43,450 --> 01:24:46,130 Excellent. I think that's a great list. And, and I gotta admit, 1354 01:24:46,200 --> 01:24:50,570 some of it isn't, you know, like the exercise, um, isn't too surprising, but to, 1355 01:24:50,570 --> 01:24:55,490 um, to see it put together in such a elegant package with explanations about 1356 01:24:55,630 --> 01:24:57,250 why, um, I, I always, 1357 01:24:57,450 --> 01:25:02,050 I always find it easier to do the healthy choice when I understand why I'm doing 1358 01:25:02,070 --> 01:25:06,290 it instead of just like feeling like I'm not allowed to have something anymore, 1359 01:25:06,380 --> 01:25:10,690 which, um, doesn't usually work super great for me, , but, um, but, but, 1360 01:25:10,710 --> 01:25:14,810 but getting inspiration to go towards something I do want, 1361 01:25:14,810 --> 01:25:18,010 like long-term brain health, especially since I've already had a brain injury, 1362 01:25:18,290 --> 01:25:21,890 I don't really have anything to, you know, I don't have much left to lose, 1363 01:25:21,990 --> 01:25:26,010 you know, I need to, I need to protect what I've got. So, so anyway, um, 1364 01:25:26,340 --> 01:25:28,730 state you, you've just been like absolutely delightful. 1365 01:25:28,850 --> 01:25:33,690 I appreciate your ability to translate, um, a lot of this, 1366 01:25:33,870 --> 01:25:37,610 you know, hardcore bench science that you do, um, you know, 1367 01:25:37,910 --> 01:25:42,770 at the university, uh, to translate it into lay language so that, 1368 01:25:43,150 --> 01:25:46,290 um, you know, you can bring some of, um, you know, 1369 01:25:46,440 --> 01:25:51,010 some of our lay people along with the citizen scientists, along with, you know, 1370 01:25:51,070 --> 01:25:56,050 the caregivers and the doctors who listen to show you kind of like provide, 1371 01:25:56,550 --> 01:26:00,730 um, in, in information in a way that, that we get to bring everybody along and, 1372 01:26:00,830 --> 01:26:03,960 um, you know, that's not a skill that everybody's got. So, um, 1373 01:26:04,120 --> 01:26:08,320 I appreciate that skill in you and, um, your good heart and your, 1374 01:26:08,320 --> 01:26:12,960 your wanting to, um, you know, uh, be here and, and help. 1375 01:26:13,020 --> 01:26:14,680 And also your willingness, like you're, 1376 01:26:14,680 --> 01:26:17,760 you're doing this interview in the future, you know, since you're in Australia, 1377 01:26:17,760 --> 01:26:20,480 you're actually doing this interview tomorrow while I'm, 1378 01:26:20,620 --> 01:26:22,840 I'm having this interview tonight, so I, 1379 01:26:22,960 --> 01:26:25,120 I appreciate a little bit of time travel as well. 1380 01:26:25,220 --> 01:26:27,400 So thank you so much for being here on Shaping Fire. 1381 01:26:28,470 --> 01:26:32,320 Well, it's been a pleasure and I hope all the listeners out there, uh, 1382 01:26:32,320 --> 01:26:37,000 benefit from everything that's been discussed over the past 90 minutes, 1383 01:26:37,300 --> 01:26:41,960 and we keep, uh, transversing into the future to help each other understand, 1384 01:26:42,380 --> 01:26:42,860 you know, 1385 01:26:42,860 --> 01:26:47,760 how natural plants and behavior and lifestyle modifications 1386 01:26:47,900 --> 01:26:52,120 can all benefit no matter what stage of, uh, life that we're at. 1387 01:26:53,120 --> 01:26:55,720 Excellent. Thank you so much. So dear listener, 1388 01:26:55,720 --> 01:26:58,720 if you want to get in contact with state and laws, 1389 01:26:58,720 --> 01:27:02,080 there is one way to do it and you can reach him, uh, 1390 01:27:02,080 --> 01:27:06,240 through his LinkedIn profile. Now, be realistic about the time. 1391 01:27:06,260 --> 01:27:09,720 It might take him to get back with you because he is actively, you know, 1392 01:27:09,720 --> 01:27:12,480 working at the university and he's in the lab every day. 1393 01:27:12,750 --> 01:27:16,520 He's not like other folks who are sitting at their computer all day or have PR 1394 01:27:16,520 --> 01:27:19,360 departments to get back with you. You know, if, if, if you, 1395 01:27:19,380 --> 01:27:22,040 if you have a question, if you want to connect or, or, 1396 01:27:22,140 --> 01:27:25,640 or especially if you have an opportunity for him, um, you can, uh, 1397 01:27:25,640 --> 01:27:29,800 reach out to him, um, through his LinkedIn. I also wanna, uh, uh, 1398 01:27:29,950 --> 01:27:34,520 plug two other episodes because if you like this idea of, of longevity and, 1399 01:27:35,020 --> 01:27:38,400 uh, nootropics, uh, you probably also want to check out, uh, 1400 01:27:38,400 --> 01:27:42,840 the last episode of shaping Fire number 1 0 8 on Longevity and the 1401 01:27:42,840 --> 01:27:45,600 Endocannabinoid System with Hunter Land. Um, 1402 01:27:45,700 --> 01:27:48,920 we talk a lot about keeping your endocannabinoid, uh, 1403 01:27:48,920 --> 01:27:53,040 system functioning over the arc of your life and things that you can do to keep 1404 01:27:53,040 --> 01:27:57,640 your endocannabinoid system functioning over time. Um, and then also, uh, 1405 01:27:57,640 --> 01:28:00,880 shaping Fire, episode 36, which goes all the way back, 1406 01:28:00,880 --> 01:28:03,080 like three or four years ago now. Um, 1407 01:28:03,300 --> 01:28:07,920 and that is with the Fantastic Robert Litman. And this is an episode on, 1408 01:28:07,980 --> 01:28:10,560 on Breathing, on cannabis and Breathing. And I gotta say, 1409 01:28:10,720 --> 01:28:14,760 I think it's one of my favorite shaping fire episodes because of the uniqueness 1410 01:28:14,820 --> 01:28:18,240 and usefulness of the information. He talks about, you know, 1411 01:28:18,700 --> 01:28:23,120 how we breathe the common mistakes people make in breathing, um, 1412 01:28:23,620 --> 01:28:26,880 how breathing in, um, uh, 1413 01:28:27,310 --> 01:28:32,240 combusted smoke and vaporizing, you know, how that functions. And, 1414 01:28:32,340 --> 01:28:36,320 um, and, and, uh, here he, he offers some, uh, 1415 01:28:36,680 --> 01:28:41,000 exercises to, uh, improve your breathing as well. It's, it's a very, uh, 1416 01:28:41,000 --> 01:28:44,080 delightful episode. And that's Shaping Fire, episode 36. 1417 01:28:45,070 --> 01:28:48,330 You can find more episodes of the Shaping Fire Podcast and subscribe to the 1418 01:28:48,330 --> 01:28:51,850 show@shapingfire.com and wherever you get your podcasts. 1419 01:28:52,190 --> 01:28:53,130 If you enjoyed the show, 1420 01:28:53,200 --> 01:28:55,890 we'd really appreciate it if you would leave a positive review of the podcast. 1421 01:28:56,410 --> 01:29:00,490 Wherever you download your view will help others find the show so they can enjoy 1422 01:29:00,490 --> 01:29:02,640 it too. On the Shaping Fire website, 1423 01:29:02,640 --> 01:29:06,280 you can also subscribe to the newsletter for insights into the latest cannabis 1424 01:29:06,390 --> 01:29:10,480 news exclusive videos and giveaways on the Shaping Fire website. 1425 01:29:10,480 --> 01:29:13,120 You also find transcripts of today's podcast as well. 1426 01:29:13,660 --> 01:29:14,880 Be sure to follow on Instagram. 1427 01:29:14,900 --> 01:29:19,800 For all original content not found on the podcast that's at Shaping Fire and 1428 01:29:19,940 --> 01:29:21,560 at shang los on Instagram, 1429 01:29:22,060 --> 01:29:25,360 be sure to check out the Shaping Fire YouTube channel for exclusive interviews, 1430 01:29:25,470 --> 01:29:27,160 farm tours, and cannabis lectures. 1431 01:29:27,670 --> 01:29:31,200 Does your company wanna reach our national audience of cannabis enthusiasts? 1432 01:29:31,610 --> 01:29:34,640 Email hotspot@shapingfire.com to find out how. 1433 01:29:34,940 --> 01:29:38,960 Thanks for listening to Shaping Fire. I've been your host, Shang Los.