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This is Crystal Olson with the Becker Healthcare

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care podcast.

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Thrilled to be joined by Doctor Joel Lil,

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Pediatric and fetal surgeon at Midwest fetal Care

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center,

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collaboration between Children's, Minnesota and Align of health.

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He is head of open fetal surgery at

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Children's, Minnesota and at the center.

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He's with us today to discuss topics that

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include the fetal care center success in treating

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My Men or M.

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Talk to. Thank you for joining us.

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Thanks for having me.

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Yes. Wonderful. Joe, what... If you don't mind,

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could you please introduce yourself and tell a

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bit about your background?

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Yeah. So, so I'm Joel Lil.

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1 of the pediatric and fetal surgeons at

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the Mid midwest fetal care center in Children's

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Minnesota and Line of health.

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1 of the

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privileges that I have is not only taking

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care of

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kids and operating on kids with surgical needs

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after they're born, I get a chance to

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meet with moms and families

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to address a lot of,

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important clinical issues, prior being born, making diagnoses,

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care plans and even,

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creating interventions,

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product kids being born in that sometimes involve

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surgeries.

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So,

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for me, this is what I spend the

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bulk of my professional life doing and probably

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the thing I'm most excited about.

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Thanks for that, Joe. Just to take the

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wider view for a second here,

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clearly really, someone in your position has a

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lot of things on their mind. Some of

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which you just laid out. But what would

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you say are the biggest issues that you're

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following in health for health care rather right

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at this moment.

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Yeah. So

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taking a step back. I mean, the answer

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to that question is kind of scale. Right?

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So

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like, nationally, it's pretty important and obvious to

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a lot of people that women's health and

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reproductive rights, especially how it affects

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our fetal care center

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are or are are big and on the

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the forefront

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for us.

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We also think about health care access and

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dollars used to subsidize

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health insurance plans and their,

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continued protection nationally.

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And then we also think about payers in

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their relationship with hospitals and providers, that dynamic

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is changing.

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It seems to change

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pretty rapidly even in my career. I've seen

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substantial changes in that.

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Improved access, but it comes with other changes.

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And you can think about things that you

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really affect our region in our state.

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Healthcare care organizations and their collaborations and ability

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to recruit talent

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to,

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sort of build in, a staff

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that,

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allows them to kind of meet care plans

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and patient needs. I think that is becoming

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an increasingly

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challenging problem in the current economic climate.

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And then you know, for our state, we

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both have a huge, like,

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metropolitan urban population, but we also serve a

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substantially,

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large,

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role

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populations. So

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we focus on and think about how our

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region will address significant budget constraints and how

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these

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programs that can be built to help our

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patients here immediately,

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will be able to not only reach the,

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sort of the greater metro area, but also,

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the rural communities.

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You know, in doing so, we have to

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build sustainable and meaningful programs that are beneficial

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the parents.

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And patients and have them be cost effective

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and sustainable.

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And the other thing that we think about

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a lot here, we have a pretty diverse

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patient population

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And we always... We think about

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equity within our health care system. And I

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think that that's 1 of the things that,

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our region is trying to overcome

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the psycho social logistical and financial obstacles of

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achieving

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excellent health care

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that is sustainable

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and and highly effective for our patients.

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And then I think about, like, things, and

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I know that our center talks about this

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and many of our providers think about this.

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Our role in our center in our hospital,

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realizing that

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we have a pretty substantial role within the

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the region and to be an effective tertiary

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quan center that provides

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partnerships to

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not only our local community, but our region

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so that we can, once again, build high

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value programs that can only be found at

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these centers that can bring a lot of

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patients and resources

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together to build,

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these complex care programs. And so I think,

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we're always trying to find creative ways to

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build solutions in this space. And I think

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that that's probably 1 of our biggest local

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challenges you know, to to strategize around those

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those

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those topics

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and move and move our programs forward in

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the fetal care center is very much

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sort of a an ama of of those

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issues.

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Thank you for laying out those balances as

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for us bill. No doubt a lot of

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your peers time relate to those and how

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you go about

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addressing them, but zooming me a little bit,

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the main reason we have you on the

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podcast today. Is to discuss the midwestern care

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center and all the success we've have in

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in M and addressing that. So you understand

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you have

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the 100

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Procedure in March?

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If you don't mind, could you please trial

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procedure and how it can improve the fe

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development?

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So many years ago,

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researchers at the University of

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of, San Francisco

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began to ask the question

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how can we improve

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the life of babies with significant fetal anomalies

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diagnosed to that we could make in euro,

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and which anomalies would benefit from an

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intervention and which would still be benefited by

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early,

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post care. The idea was is that Sp

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is a disease that

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became

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kind of an important target because it was

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a non lethal disorder that affected 1 in

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3000 patients, so a pretty significant number of

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patients

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worldwide in particular in North America,

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and,

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these patients in general are all going to

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be born but formed with substantial deficits

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when you think about the procedure, you sort

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of have to figure

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and and and why we do a fetal

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intervention, you have to figure... You have to

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understand the disease a little bit. The disease

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itself affects the brain by creating swelling and

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blockages in the brain

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because of loss of cerebral spinal fluid out

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the back.

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Where the defect is seen. It causes hernia

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of,

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important contents of the brain that can compress

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on critical centers of the brain.

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The defect itself in spin of if is

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a lack of,

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proper covering of the neural elements, the spinal

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cord to the nerves of the back.

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And

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that creates also nerve injury to all the

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levels of the nerves affected at the level,

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the defect and below. So if you have

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at a defect in the, lower back, which

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is the most common to see this, you

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can have substantial deficits

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and dysfunction with bowel bladder function

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and lower extremity, motor and sensory function where

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many of these kids, the majority of these

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kits are

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wheelchair bound in their,

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pre teen and in teen years,

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we requiring

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substantial medical intervention for bound bladder programs,

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and needing multiple neurosurgery and orthopedic surgeries

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to help

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maintain

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the best quality of life for these patients.

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So what we found is in,

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the early research that if we could

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close the back of these babies, much like

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we do after they're born,

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we can,

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improve the disease project... Trajectory or the disease

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path for these patients.

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And the reason being is that not only

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do you

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stop that leakage of cerebral spinal fluid as

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it leaks out the back, but You also

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protect the neural elements from,

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being,

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injured by the am antibiotic fluid that does

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pretty toxic to

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developing nerves.

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So if we

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create a,

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a closure technique, a water closure technique to

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those neuro elements,

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between 23 and 26 weeks, what we see

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is a significant improvement

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in the disease

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progression of these kids. It doesn't cure the

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disease, but it greatly am the disease.

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So the surgery is done

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now a couple different ways.

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Initially, it was done through,

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like, a lower abdominal typical c section incision

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where we would open up the abdomen a

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bomb

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and expose the uterus and find a place

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on the uterus a safe distance away from

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the placenta

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and create about a 6 to 8 centimeter

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opening in the uterus to expose the back

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of the baby and then in multiple layers,

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close the back of the baby, then close

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the uterus, close moms

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abdominal wall and let the baby

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continue ge dating for another

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10 to 13 weeks.

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We've since advanced our approach

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and

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begun doing things through a minimally invasive approach

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or ph approach where we can do all

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the same exact closure techniques, but through small

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little 5 millimeter incision, 3 of them, through

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the uterus.

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That ema a lot of the morbidity and

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potential morbidity for mom

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in future pregnancies

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and allows for moms to continue on their

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pregnancy and have at vaginal delivery whereas the

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open

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incision on the uterus means that mom needs

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to have a a future C section,

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and all future pregnancies need a c section.

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And when we do this, we know is

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a population of patients,

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we take and we improve their shu rates

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the need for draining that fluid from the

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brain,

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we reduce it substantially.

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And sometimes as much as 4 fold reduction

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in shu rates. We can

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improve dramatically the high brain hernia rate. We

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improve neuro scores or Iq scores and functioning

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we have substantial improvements in bladder program,

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or bladder function.

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And then we have... We doubled the number

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of una

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una

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in this patient population. So we were taking

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kids that would otherwise be severely affected needing

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assisted in their ambition, whether it's crutches or

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thought braces, where been wheelchairs, and we're doubling

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the number of kids

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who don't require any assistance in.

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So we're improving their life significantly.

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So that's that's the reason why we do

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it, that's kinda how we do it.

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And we're always looking as a as a

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as a field to improve

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not only the procedure decreasing the the risk

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to mom and baby, but to also improve

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our outcomes.

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Wow, doctor. This is just incredible that this

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procedure even exists really that you're able to

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improve children's lives in such a way before

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they born.

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Right looking ahead,

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now that you've seen that this procedure is

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successful

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what do you think might be the next

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evolution of treatment in this area?

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Well, for Spine, in particular,

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I think that

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understanding the path physiology or how spin

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develops,

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being able to prevent it or treated even

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earlier so that we can have improved outcomes.

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And treatment earlier, I think may involve non

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surgical means for treatment or even more minimally

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invasive means for treatment.

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And I think this is a hugely interesting

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topic thinking about providing coverage to those neural

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elements through

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cell based therapy approach that could be delivered

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with just a simple needle,

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instead of needing a more complex surgery, or

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thinking about how to,

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prevent

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the molecular mechanisms that lead to

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the

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the spin of bi defect itself. So I

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think that's the future for this. But I

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think in general,

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being able to do fetal surgery for by

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open the door

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to fetal surgery in general, being able to

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teach us how to not only perform the

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surgery as a field

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but also expand the number of

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potential diseases and targets that would benefit from

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fetal surgery.

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So now we do fetal surgery

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for other indications, sometimes,

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very large and impactful tumors that would be

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otherwise fatal for the fe us.

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We do fetal interventions for, a number of

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other

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indications such as twin pregnancies that,

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have un unbalanced sharing of blood,

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So there's a number of other indications that

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have really grown out of this, early fetal

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surgical experience. And I hope to in the

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future that we're able to target more fetal

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anomalies

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so that we can improve outcomes for patients

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and families, but also reduce the burden of

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health care costs within the system.

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Here's hoping a lot of those treatments that

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you mentioned, Doctor are going to arrive sooner

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rather of than later although See there's a

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lot of research and work to be done

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before that happens. Lastly, I simply wanna ask

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you as someone who is a leader in

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health

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What do you think leaders needs to be

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successful in the field in the next 2

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to 3 years?

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Yeah. I so, you know, I think about

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how even

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25 years ago, when when I thought about

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science and medicine,

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a lot of work was happening

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still in silos and

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people competed with programs,

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and they looked at how they could advance

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a particular area

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or a particular field, but in a very

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limited way.

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I think we're at a point now we've

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seen so much advancement in technology and our

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knowledge that

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healthcare leaders need to... From a science standpoint,

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be able to integrate the knowledge that we're

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developing between different fields, get out of our

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silos and be able to integrate

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usable solutions for patients. So basically translate our

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research to usable results to our patients. And

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I think you you all take that same

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theme from science and you apply it to

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the strategy of the business of running a

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hospital in a healthcare care system,

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patients need integrated care plans. And

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this also solves a second problem, which is

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to do things in a sustainable way. We

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00:14:26,470 --> 00:14:29,049
need to have high value, high quality

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00:14:29,364 --> 00:14:32,787
care plans and care programs for patients that

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can address

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a number of different patient populations

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And I think that if we do that,

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we'll be able to be able to to

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deliver

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these really complex care solutions and plans in

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a sustainable way rather than in a competitive

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00:14:47,031 --> 00:14:49,857
or 1 off way that isn't very sustainable

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or really in the interest of program billing

398
00:14:52,706 --> 00:14:55,178
in collaboration, which is what our parent patients

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demand of us.

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Doctor Thank Being so generous through time and

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00:14:59,498 --> 00:15:01,731
insights today. We absolutely cannot wait to share

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00:15:01,731 --> 00:15:03,086
them with our audience, and we look forward

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to connecting with you again soon.

404
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Alright. Thank you so much. Appreciate it.