1 00:00:00,360 --> 00:00:03,760 This is the Art Beauty podcast, where we are always reaching for truth 2 00:00:03,760 --> 00:00:04,720 in beauty. 3 00:00:04,720 --> 00:00:06,440 Remember, the brands of the people on the show 4 00:00:06,440 --> 00:00:09,280 are not paying to be here, so we get to ask those tough questions. 5 00:00:09,280 --> 00:00:12,120 We know you want answered because you deserve to be informed 6 00:00:12,120 --> 00:00:15,120 so you can make the best choices for yourself. 7 00:00:15,160 --> 00:00:20,120 With that said, I'm Amber, Milk and today, My fabulous co-host is Dr. 8 00:00:20,120 --> 00:00:21,040 Saranya Wyles. 9 00:00:21,040 --> 00:00:24,560 She's a board certified dermatologist with a Ph.D. 10 00:00:24,600 --> 00:00:26,480 in regenerative medicine. 11 00:00:26,480 --> 00:00:28,640 She works at a little place called the Mayo Clinic. 12 00:00:28,640 --> 00:00:32,080 So I think we know that she's got some credibility here. 13 00:00:32,160 --> 00:00:35,480 She also led the clinical trials 14 00:00:35,560 --> 00:00:40,520 for Plated, which is an exosome product that we will be discussing. 15 00:00:40,600 --> 00:00:42,160 But before we get into that first. 16 00:00:42,160 --> 00:00:45,120 Welcome to the show, Dr. Wyles. Really appreciate you having. 17 00:00:45,120 --> 00:00:48,080 Really appreciate you being here with us today. 18 00:00:48,080 --> 00:00:48,760 Thanks, Amber. 19 00:00:48,760 --> 00:00:50,640 It's great to be here with you. 20 00:00:50,640 --> 00:00:53,640 So, you know, we keep it honest here 21 00:00:53,720 --> 00:00:58,920 and I am so excited about this episode today because we we did 22 00:00:58,920 --> 00:01:02,160 I did in an episode on Exosome 23 00:01:02,240 --> 00:01:05,800 products, specifically in topical products. 24 00:01:05,800 --> 00:01:09,960 You take it home, not things that are injected or applied after, 25 00:01:10,040 --> 00:01:14,200 you know, you've had some sort of laser treatment 26 00:01:14,280 --> 00:01:17,720 and then, you know, it's the beauty business, right? 27 00:01:17,720 --> 00:01:20,000 So things are always changing. 28 00:01:20,000 --> 00:01:23,160 And then I started to really dive into Exosomes. 29 00:01:23,160 --> 00:01:26,040 So I was familiar with the Elevate product. I used it. 30 00:01:26,040 --> 00:01:29,880 I felt like it made my skin a little bit more clear. 31 00:01:29,960 --> 00:01:32,640 But then when I started kind of really digging around 32 00:01:32,640 --> 00:01:34,440 and doing a little more research, I found that 33 00:01:34,440 --> 00:01:38,320 there was a lot of conflicting information on Exosomes. 34 00:01:38,400 --> 00:01:41,840 With some doctors who were like, yes, this is that the the 35 00:01:41,880 --> 00:01:45,880 the newest, hottest thing to do and other doctors who are like, well, 36 00:01:46,080 --> 00:01:49,360 there's things we need to be concerned a bit a little bit about. 37 00:01:49,360 --> 00:01:50,520 And I'm hoping today, Dr. 38 00:01:50,520 --> 00:01:53,520 Wells, that you can help us kind of clear some of that up. 39 00:01:53,720 --> 00:01:58,160 So to start with, can you give us a very brief explainer 40 00:01:58,320 --> 00:02:01,320 and a reminder of what exosomes are? 41 00:02:01,560 --> 00:02:02,560 Absolutely. Amber. 42 00:02:02,560 --> 00:02:04,440 And I think a lot of the scientific 43 00:02:04,440 --> 00:02:08,600 rhetoric that comes around with the terminology is new to people. 44 00:02:08,600 --> 00:02:13,600 And when you have a disruptive technology with new information and new terms, 45 00:02:13,680 --> 00:02:15,040 you have two camps. 46 00:02:15,040 --> 00:02:17,320 Part of the people who understand it, they're onboard 47 00:02:17,320 --> 00:02:18,440 because they see it working. 48 00:02:18,440 --> 00:02:23,160 And then the other part are skeptical and want to learn more. 49 00:02:23,160 --> 00:02:25,240 But there's concerns about it. 50 00:02:25,240 --> 00:02:29,640 So let's break it down, starting from the basics, which is what is an exosome. 51 00:02:29,720 --> 00:02:33,240 So and Exosome is just a message from a cell 52 00:02:33,440 --> 00:02:36,800 and we could think about it like letters or signals. 53 00:02:36,960 --> 00:02:40,760 They have a single signal message that they're communicating to another cell. 54 00:02:40,760 --> 00:02:44,680 So it could be anything like repair, restore, 55 00:02:44,680 --> 00:02:47,920 it could be multiply or divide for a cell. 56 00:02:48,000 --> 00:02:50,240 It could also be harmful, like metastasized. 57 00:02:50,240 --> 00:02:54,840 So this is where the key is, the source of the exosome. 58 00:02:54,920 --> 00:02:56,600 Where is it coming from? 59 00:02:56,600 --> 00:02:57,560 What are the cell 60 00:02:57,560 --> 00:03:00,640 or the source that it's coming from that really distinguishes the product? 61 00:03:00,640 --> 00:03:03,640 So the first question when somebody is talking about 62 00:03:03,640 --> 00:03:06,840 exosome technology should naturally be, well, what is the source? 63 00:03:06,920 --> 00:03:08,760 And there's great variability. 64 00:03:08,760 --> 00:03:13,000 So if we kind of think about it as 65 00:03:13,080 --> 00:03:14,400 pasta, you 66 00:03:14,400 --> 00:03:18,240 can kind of have different types of pasta and with different sauce 67 00:03:18,240 --> 00:03:22,080 and different types of dressings and things like that. 68 00:03:22,080 --> 00:03:25,920 So this is really where you just have a blanket terminology 69 00:03:25,920 --> 00:03:28,560 and you really want to ask the next steps or the next questions 70 00:03:28,560 --> 00:03:32,760 to better understand what it is and how to how to use it. 71 00:03:32,840 --> 00:03:36,040 Now, I'm so glad you brought that up because, you know, when you were saying 72 00:03:36,040 --> 00:03:41,160 harmful, like you want to make sure that your exosomes aren't being sourced 73 00:03:41,160 --> 00:03:45,920 from somebody who is either genetically predisposed to cancer or had cancer. 74 00:03:45,920 --> 00:03:49,040 Because as you said, those exosomes would be sending cells 75 00:03:49,040 --> 00:03:54,240 to messages to your cells that could affect them in negative ways. 76 00:03:54,320 --> 00:03:58,400 So as consumers, how are we supposed to know this? 77 00:03:58,400 --> 00:04:02,640 Because as far as I understand, the FDA is has not approved any exosomes 78 00:04:02,640 --> 00:04:08,000 and they've actually sent warnings to consumers about, you know, 79 00:04:08,080 --> 00:04:10,120 about using them. 80 00:04:10,120 --> 00:04:10,800 Exactly. 81 00:04:10,800 --> 00:04:13,400 So let's talk about what the FDA can regulate. 82 00:04:13,400 --> 00:04:17,000 And really, it's a gray area when it comes to cosmetic applications, 83 00:04:17,240 --> 00:04:20,600 But as long as we're applying it on intact skin, 84 00:04:20,680 --> 00:04:24,320 and that includes really disrupting the skin barrier. 85 00:04:24,320 --> 00:04:27,640 So this is where we really have to be cautious and emphasize 86 00:04:27,640 --> 00:04:31,560 that there are currently no injectable exosome products that are approved 87 00:04:31,800 --> 00:04:33,400 even for cosmetic purposes. 88 00:04:33,400 --> 00:04:38,920 You cannot inject exosomes, and that's FDA has been very clear about that. 89 00:04:39,000 --> 00:04:41,440 Now when you apply the product topically 90 00:04:41,440 --> 00:04:47,040 on skin for appearance of skin aging, redness for size, etc., 91 00:04:47,280 --> 00:04:50,160 that is that lies within that cosmetic realm, 92 00:04:50,160 --> 00:04:54,200 which the FDA doesn't necessarily regulate but does surveil. 93 00:04:54,360 --> 00:04:58,600 So this is where you need to make sure the company has the right strategies, 94 00:04:58,760 --> 00:05:02,320 the right manufacturing, so that the product that they're offering 95 00:05:02,320 --> 00:05:05,800 or sharing is under the guidelines of the FDA. 96 00:05:05,880 --> 00:05:08,400 Now, you know, I want to talk about the injectables, 97 00:05:08,400 --> 00:05:09,400 because that is something 98 00:05:09,400 --> 00:05:12,400 that we sort of heard, you know, k-beauty we know K-beauty a lot of that, 99 00:05:12,400 --> 00:05:16,120 but that is actually a very popular treatment in Korea 100 00:05:16,200 --> 00:05:20,520 is this idea of injectable skin boosters here. 101 00:05:20,600 --> 00:05:21,760 You know, in the States, 102 00:05:21,760 --> 00:05:26,160 I think what's much more common is for people to see in-office exosomes 103 00:05:26,200 --> 00:05:30,360 being applied after you've had either microneedling some sort of a laser. 104 00:05:30,360 --> 00:05:35,200 I myself have had some microneedling before. 105 00:05:35,280 --> 00:05:38,280 So. So is it just that we need to be, 106 00:05:38,320 --> 00:05:41,240 you know, trusting, I guess, our doctor, that our doctors doing the research 107 00:05:41,240 --> 00:05:44,480 to make sure that these are sourced from reliable companies? 108 00:05:44,560 --> 00:05:46,520 Yes. So let's talk about sourcing a little bit, 109 00:05:46,520 --> 00:05:50,400 because this is unlike any other product that we see on the market. 110 00:05:50,400 --> 00:05:51,920 So what do I mean by that? 111 00:05:51,920 --> 00:05:56,280 I mean that when you go into a store to buy a product, whether it's 112 00:05:56,520 --> 00:06:01,040 glycolic acid or salicylic acid, so those are active ingredients 113 00:06:01,080 --> 00:06:06,480 where you know that those active actives are the same in every single product. 114 00:06:06,480 --> 00:06:09,240 The batch to batch chemistry is the same. 115 00:06:09,240 --> 00:06:12,480 Now when it comes to Exosomes, these are sourced from humans. 116 00:06:12,480 --> 00:06:17,720 So there's great variability in that human source of what cell is it coming from? 117 00:06:17,720 --> 00:06:21,920 Is it coming from one donor, one person, or is it coming from batch donors? 118 00:06:21,920 --> 00:06:25,160 Collective combination of multiple pooled donors. 119 00:06:25,360 --> 00:06:28,280 And then you have to think about how are they manufacturing it 120 00:06:28,280 --> 00:06:30,160 because it can come from human sources. 121 00:06:30,160 --> 00:06:34,280 You have to use good manufacturing practices or clinical very good 122 00:06:34,280 --> 00:06:40,120 manufacturing practices, clean labs, clean rooms, product handling 123 00:06:40,200 --> 00:06:43,400 gowns, loving all of these things that you wouldn't normally think about 124 00:06:43,400 --> 00:06:45,800 in your chemistry of Cosmeceuticals 125 00:06:45,800 --> 00:06:49,320 come into play with the bio manufacturing of Exosomes So this is where 126 00:06:49,560 --> 00:06:53,960 we really have to think about this as not every product is the same. 127 00:06:54,120 --> 00:06:57,560 And how you make the exosomes is really important. 128 00:06:57,560 --> 00:07:00,880 And the sterility safety, the reproducibility 129 00:07:00,880 --> 00:07:04,440 meeting batch to batch consistency is is validated. 130 00:07:04,440 --> 00:07:05,520 So those are some of the things 131 00:07:05,520 --> 00:07:09,600 that you have to ask the manufacturer Where are these manufactured from? 132 00:07:09,680 --> 00:07:12,240 Who are the donors? Is it one multiple? 133 00:07:12,240 --> 00:07:18,520 And then how are they kind of ensuring that the product is consistent and 134 00:07:18,600 --> 00:07:20,920 reproducible with each batch? 135 00:07:20,920 --> 00:07:24,920 I mean, for the regular person at home, is there a way for us 136 00:07:25,000 --> 00:07:29,000 to sort of find out that information or is it just writing to, 137 00:07:29,040 --> 00:07:32,480 you know, either that the cosmetic company, the parent company, 138 00:07:32,560 --> 00:07:36,840 but do you have any that you know or or why I like to do this 139 00:07:36,840 --> 00:07:40,280 podcast is bringing on trusted people like yourself, right, 140 00:07:40,320 --> 00:07:44,080 who work at the Mayo Clinic, who specialize in this, 141 00:07:44,160 --> 00:07:44,880 who are here. 142 00:07:44,880 --> 00:07:47,880 Clearly, you are supporting a brand, 143 00:07:48,000 --> 00:07:52,400 but I do think that your credibility does lend to a little bit 144 00:07:52,400 --> 00:07:56,520 more trust than necessarily having, you know, somebody hate to say this from 145 00:07:56,520 --> 00:08:00,280 PR coming on saying this is the best, greatest thing. 146 00:08:00,360 --> 00:08:02,720 Is there anything that we can do at home to kind of ensure 147 00:08:02,720 --> 00:08:06,840 that our products are coming from a safe place? 148 00:08:06,920 --> 00:08:09,920 Yes. And to get that credibility, 149 00:08:09,920 --> 00:08:13,560 the company needs to invest in validating its technology. 150 00:08:13,640 --> 00:08:14,360 What does that mean? 151 00:08:14,360 --> 00:08:16,360 That means they need to be doing FDA 152 00:08:16,360 --> 00:08:20,160 clinical trials in the product for different medical indications. 153 00:08:20,360 --> 00:08:24,200 So even a company like Plated has the parent company region 154 00:08:24,440 --> 00:08:27,440 and they have different clinical trials that's ongoing. 155 00:08:27,440 --> 00:08:29,560 So this is where the consumer can go. 156 00:08:29,560 --> 00:08:34,320 On clinicaltrials.gov, which is an open access public website, 157 00:08:34,520 --> 00:08:40,880 and you just type in the source and see if the company has FDA INDs ongoing, 158 00:08:41,080 --> 00:08:45,080 meaning do they have medical indications that they're trying this for? 159 00:08:45,240 --> 00:08:49,080 That means they have a good background of manufacturing. 160 00:08:49,080 --> 00:08:53,080 You know, that the FDA has really delve deep into making sure 161 00:08:53,080 --> 00:08:56,280 that the products are manufactured consistently because they're looking 162 00:08:56,280 --> 00:09:00,920 to approve the product for many people and safety, which is a big concern 163 00:09:01,000 --> 00:09:02,280 and regulation for FDA. 164 00:09:02,280 --> 00:09:06,840 So you want to make sure that the company is has FDA 165 00:09:06,840 --> 00:09:10,680 studies ongoing that is separate for medical indications. 166 00:09:10,680 --> 00:09:13,120 And if they have that, then that's good reason to believe 167 00:09:13,120 --> 00:09:17,400 that they've invested in and trusted manufacturing processes. 168 00:09:17,480 --> 00:09:20,040 Here's a little thing to anybody from Plated who's listening. 169 00:09:20,040 --> 00:09:22,040 You guys on your website should have a link 170 00:09:22,040 --> 00:09:24,200 to some of these clinical trials because I think 171 00:09:24,200 --> 00:09:27,200 that it was kind of hard to find out like, well, wait, where are these coming from? 172 00:09:27,200 --> 00:09:27,880 What's going on? 173 00:09:27,880 --> 00:09:31,240 But that's another, that's another conversation altogether. 174 00:09:31,240 --> 00:09:33,760 Maybe I'll write them a little letter. 175 00:09:33,840 --> 00:09:37,440 So okay, So once we, you know, have this idea of that, 176 00:09:37,520 --> 00:09:42,080 we're at least getting trusted source is let's talk 177 00:09:42,080 --> 00:09:45,640 a little bit about the different sources that that exosomes come from. 178 00:09:45,640 --> 00:09:48,880 So I know that plated comes from platelets versus 179 00:09:48,880 --> 00:09:52,840 elevated VI which were taken from the umbilical cord. 180 00:09:52,920 --> 00:09:54,120 What's the difference? 181 00:09:54,120 --> 00:09:56,080 Why does that matter? 182 00:09:56,080 --> 00:09:57,720 Great question. So let's break it down. 183 00:09:57,720 --> 00:10:02,360 So if we were to look at umbilical cord, this is from the cord blood of babies, 184 00:10:02,520 --> 00:10:06,840 and you can understand that each cord blood source is different. 185 00:10:07,040 --> 00:10:11,160 So you have to understand, is it one or two donors 186 00:10:11,360 --> 00:10:14,200 or is it multiple donors that they're combining 187 00:10:14,200 --> 00:10:17,280 the cord blood stem cells the other way, 188 00:10:17,280 --> 00:10:22,200 that the exosomes are manufactured is that they have to be cultured in a lab. 189 00:10:22,440 --> 00:10:26,560 So if it's coming from stem cells, so look for the buzz word stem cells 190 00:10:26,560 --> 00:10:27,800 so they can be bone 191 00:10:27,800 --> 00:10:31,920 marrow stem cells, adipose stem cells, umbilical cord blood stem cells. 192 00:10:32,080 --> 00:10:35,400 So those stem cell sources need to be taken to a lab 193 00:10:35,560 --> 00:10:38,680 where they're expanded over and over and over again. 194 00:10:38,880 --> 00:10:39,840 And then they take 195 00:10:39,840 --> 00:10:44,680 what's called the culture media or the soup that the cells grow in. 196 00:10:44,760 --> 00:10:48,000 They basically take that media out and then they distill 197 00:10:48,000 --> 00:10:50,280 the exosomes down from that. 198 00:10:50,280 --> 00:10:53,120 So think about that as an intermediate step. 199 00:10:53,120 --> 00:10:57,280 So you have the cord blood that's taken from the patient. 200 00:10:57,360 --> 00:11:00,760 You take it to the lab where this is the biomanufacturing 201 00:11:00,760 --> 00:11:04,600 making sure that there are sterility, good manufacturing processes. 202 00:11:04,600 --> 00:11:07,840 It's all handled under compliance and then it's expanded. 203 00:11:07,840 --> 00:11:10,600 So this takes weeks, two months even. 204 00:11:10,600 --> 00:11:13,840 And then your question is, are you using the same source? 205 00:11:13,840 --> 00:11:18,720 So after several months you have something called phenotypic deviation. 206 00:11:18,720 --> 00:11:21,840 And the other way to think about it is that it kind of changes when you take 207 00:11:21,840 --> 00:11:25,440 something from its normal environment and you put it in a different environment. 208 00:11:25,440 --> 00:11:27,600 It tends to adapt to the new environment. 209 00:11:27,600 --> 00:11:32,280 So how do you guarantee that that product is the same as when you harvested it 210 00:11:32,280 --> 00:11:37,360 in the beginning from the fat tissue or bone marrow or umbilical cord? 211 00:11:37,440 --> 00:11:40,040 So that's important to keep in mind for stem cells. 212 00:11:40,040 --> 00:11:40,840 Okay. 213 00:11:40,840 --> 00:11:44,400 And so what's the difference with platelets? 214 00:11:44,480 --> 00:11:45,040 Great question. 215 00:11:45,040 --> 00:11:47,360 So the platelets are a blood based source. 216 00:11:47,360 --> 00:11:50,880 So when you get blood, it's from multiple different donors. 217 00:11:51,000 --> 00:11:52,440 They're near expiration platelets. 218 00:11:52,440 --> 00:11:57,440 So we're not depleting from the source that the patients may need for use. 219 00:11:57,520 --> 00:12:00,240 So when you get these platelets, they're pooled. 220 00:12:00,240 --> 00:12:03,560 So first you take away the outliers. 221 00:12:03,560 --> 00:12:05,400 So people that are poor performers 222 00:12:05,400 --> 00:12:09,280 or super performers and you kind of average them in together 223 00:12:09,480 --> 00:12:12,760 when you kind of get all the platelets pooled together. 224 00:12:12,760 --> 00:12:16,640 So that's how one way to guarantee that consistency, 225 00:12:16,640 --> 00:12:20,200 that batch to batch consistency that we talked about. 226 00:12:20,280 --> 00:12:23,760 So pooled platelets and they're processed immediately. 227 00:12:23,760 --> 00:12:27,480 So there's no step of going to platelets are actually cell free already. 228 00:12:27,480 --> 00:12:30,480 So platelets in a way are kind of exosomes themselves. 229 00:12:30,640 --> 00:12:33,640 They come from a parent cell called a mega carrier site, 230 00:12:33,840 --> 00:12:37,400 and that's when the bone marrow and then this just kind of spews out. 231 00:12:37,400 --> 00:12:40,760 So platelets don't have that DNA, they don't have that. 232 00:12:40,840 --> 00:12:44,560 The genetic information that we are we could be concerned about. 233 00:12:44,560 --> 00:12:48,040 It's not a cell in that in that true cell sense. 234 00:12:48,120 --> 00:12:51,400 So when you take the platelets, you actually disrupt them 235 00:12:51,480 --> 00:12:57,400 and you collect the exosomes that is being released from the platelets. So 236 00:12:57,480 --> 00:12:59,720 and the way to do that is proprietary. 237 00:12:59,720 --> 00:13:01,200 They actually take out 238 00:13:01,200 --> 00:13:05,640 all of the other particles and then what's left is the exosomes. 239 00:13:05,640 --> 00:13:10,080 So it's sort of like a sieve that they kind of sort of distill down 240 00:13:10,120 --> 00:13:14,880 all of the non exosome products so that you have exosomes leftover. 241 00:13:14,960 --> 00:13:18,640 Okay, So you know what a little light bulb just went off and tell me if I'm right. 242 00:13:18,640 --> 00:13:22,040 So essentially when you take 243 00:13:22,120 --> 00:13:26,640 brands like Olivia had stem cell based exosomes, these are platelets 244 00:13:26,640 --> 00:13:30,280 based exosomes and gosh, it's been a while since they took a science class. 245 00:13:30,280 --> 00:13:31,280 But platelets are essentially 246 00:13:31,280 --> 00:13:34,560 what your body releases in response to inflammation, correct? 247 00:13:34,640 --> 00:13:36,160 Exactly. Yes. 248 00:13:36,160 --> 00:13:39,240 Okay. Okay. Got it. Okay. So amazing. 249 00:13:39,240 --> 00:13:41,440 Okay, got it. So it's actually a different type of cell. 250 00:13:41,440 --> 00:13:43,000 And you brought up a good point. 251 00:13:43,000 --> 00:13:48,560 You know, with the stem cell based ones, they have found in Exosomes DNA and RNA. 252 00:13:48,560 --> 00:13:51,240 Right. Like a lot of we have heard these buzz words. 253 00:13:51,240 --> 00:13:54,240 So platelets don't have any of that information in them. 254 00:13:54,480 --> 00:13:55,400 No DNA. 255 00:13:55,400 --> 00:13:59,320 You have a microarray days which are again messengers. 256 00:13:59,400 --> 00:14:04,360 So there post there they are a step down so it's not true genetic material. 257 00:14:04,440 --> 00:14:07,800 So it's just a signal and it's actually a mixed bag of signals 258 00:14:07,800 --> 00:14:09,240 because sometimes we get asked the question, 259 00:14:09,240 --> 00:14:12,240 what's in the next is what exactly is composed in there? 260 00:14:12,360 --> 00:14:13,880 What's the message? 261 00:14:13,880 --> 00:14:18,160 It's actually pieces of message of a lot of different signals 262 00:14:18,160 --> 00:14:22,640 that come together and that they say repair or regenerate. 263 00:14:22,640 --> 00:14:24,000 And this is where 264 00:14:24,000 --> 00:14:28,840 the source becomes really key because the platelets normally do that. 265 00:14:28,920 --> 00:14:32,520 Like you pointed out, they are the first responders to wound healing. 266 00:14:32,520 --> 00:14:36,120 So they naturally have that propensity to regenerate. 267 00:14:36,200 --> 00:14:39,200 I'm going to sites of wound, I'm going to repair this site. 268 00:14:39,320 --> 00:14:42,160 So they they release signals of repair. 269 00:14:42,160 --> 00:14:46,120 So that's where that exosome source is important. 270 00:14:46,200 --> 00:14:52,520 Now, you know, I hate to dumb this down because you are obviously brilliant, but 271 00:14:52,600 --> 00:14:53,640 is the idea 272 00:14:53,640 --> 00:14:57,440 that essentially an exorcism will be applied 273 00:14:57,440 --> 00:15:00,840 and tell your own skin cells, the ones that aren't acting 274 00:15:00,840 --> 00:15:04,280 in a reparative mode, Hey, wake up and start doing your job. 275 00:15:04,280 --> 00:15:06,720 Is that kind of what's going on here? 276 00:15:06,720 --> 00:15:09,960 Yeah, I love this question, Amber, because basically what this is, 277 00:15:09,960 --> 00:15:11,240 is disruptive technologies. 278 00:15:11,240 --> 00:15:13,720 There's no product that has been this way. 279 00:15:13,720 --> 00:15:17,040 So if you think about growth factors, peptides, anything else 280 00:15:17,040 --> 00:15:20,480 that you're putting on your skin, they work outside of the cell, 281 00:15:20,480 --> 00:15:25,240 so they're kind of creating messages outside Exosomes work inside the cell. 282 00:15:25,240 --> 00:15:28,560 They actually have the capacity to go in and deliver a signal. 283 00:15:28,760 --> 00:15:31,800 So this is really new because you think about it as a mechanic. 284 00:15:31,800 --> 00:15:35,640 Instead of working on top of the car, the mechanic is now working under the hood 285 00:15:35,840 --> 00:15:37,720 and that's really where Exosomes come into 286 00:15:37,720 --> 00:15:42,760 play of creating a new way of working with the cells. 287 00:15:42,840 --> 00:15:44,240 Okay, So 288 00:15:44,240 --> 00:15:45,760 thank you so much for getting into this. 289 00:15:45,760 --> 00:15:47,520 I'm so glad we were able to address 290 00:15:47,520 --> 00:15:50,360 some of the concerns that people are having. 291 00:15:50,360 --> 00:15:52,440 Let's talk a little bit about this technology. 292 00:15:52,440 --> 00:15:56,480 So, you know, from personal experience, I had a scar here 293 00:15:56,480 --> 00:15:59,520 that came from a laser treatment got wrong. 294 00:15:59,760 --> 00:16:04,120 I had Exosome Microneedling and the scar healed. 295 00:16:04,120 --> 00:16:06,200 I mean, is basically invisible now. 296 00:16:06,200 --> 00:16:09,640 So I've seen that it can work. 297 00:16:09,720 --> 00:16:13,800 But when we talk about topical skin care, how are we making sure 298 00:16:13,800 --> 00:16:18,120 that those messages are getting to areas where we where we need them to go? 299 00:16:18,120 --> 00:16:21,720 Right where we we haven't had a treatment like a laser or microneedling 300 00:16:21,720 --> 00:16:25,480 where we have these little channels now how does that work? 301 00:16:25,560 --> 00:16:28,560 So here's my question for you, which is that 302 00:16:28,680 --> 00:16:32,560 people have the assumption that a topical exosome 303 00:16:32,640 --> 00:16:35,880 product cannot penetrate the skin barrier, but that is incorrect 304 00:16:35,880 --> 00:16:38,880 and that's actually what we have found in our clinical study. 305 00:16:39,000 --> 00:16:43,920 So when we applied twice daily application of the plated gold 306 00:16:43,920 --> 00:16:47,040 and we followed these patients for six weeks and actually 307 00:16:47,040 --> 00:16:50,800 even up to six months, we saw considerable improvement in their skin. 308 00:16:50,800 --> 00:16:54,120 But beyond that, at 12 weeks, we biopsied the skin 309 00:16:54,280 --> 00:16:57,520 and we looked underneath the hood and saw what was happening. 310 00:16:57,600 --> 00:17:00,000 This is where we actually found Exosomes 311 00:17:00,000 --> 00:17:04,000 that have been able to be identified in the collagen fibrils. 312 00:17:04,000 --> 00:17:06,720 So we're actually getting ready to publish this data soon. 313 00:17:06,720 --> 00:17:09,720 And we submitted our data for the histology studies, 314 00:17:09,720 --> 00:17:12,720 which is really exciting because what we're seeing is that 315 00:17:12,840 --> 00:17:17,640 you can have physiological change, new collagen, new elastin 316 00:17:17,640 --> 00:17:21,760 with just topical application, no microneedling, no lasers, 317 00:17:21,840 --> 00:17:25,800 no adjuvant procedures, this is just topical application. 318 00:17:25,800 --> 00:17:28,000 So part of that is two things. 319 00:17:28,000 --> 00:17:32,040 One is has it been manufactured appropriately the right way 320 00:17:32,040 --> 00:17:35,200 so that the exosomes are intact because you can rupture them 321 00:17:35,200 --> 00:17:37,800 and if you rupture them then they are no longer 322 00:17:37,800 --> 00:17:41,760 going to be able to produce that signal or share that message. 323 00:17:41,760 --> 00:17:43,920 So manufacturing is key there. 324 00:17:43,920 --> 00:17:49,240 But the second thing that's important is how the exosome size is. 325 00:17:49,240 --> 00:17:52,200 So the size of the exosomes very, very small. 326 00:17:52,200 --> 00:17:55,120 And we know that the skin can allow 327 00:17:55,120 --> 00:17:59,400 anything less than 500 kill adults and to penetrate into the skin barrier. 328 00:17:59,400 --> 00:18:03,320 So these are very, very small particles and they're carried right in, and that's 329 00:18:03,320 --> 00:18:05,160 what our study showed. 330 00:18:05,160 --> 00:18:10,960 So now talk a little bit, because your relationship with plated, 331 00:18:11,040 --> 00:18:11,920 like I said, you work 332 00:18:11,920 --> 00:18:14,920 with the Mayo Clinic, you do clinical trials, right? 333 00:18:14,920 --> 00:18:17,520 Correctly through the Mayo Clinic. 334 00:18:17,520 --> 00:18:22,400 So how did how did you sort of get involved with plated? Yes. 335 00:18:22,400 --> 00:18:26,360 So this was sort of very fortuitous, 336 00:18:26,600 --> 00:18:29,360 right place at the right time, I would say 337 00:18:29,360 --> 00:18:32,120 I actually came I thought I was going to be a cardiologist 338 00:18:32,120 --> 00:18:37,080 and like Mayo Clinic to do my medical training with Dr. 339 00:18:37,080 --> 00:18:38,360 Andre Chozick and Dr. 340 00:18:38,360 --> 00:18:42,760 Otto, who are the founders of Plated and Rion. 341 00:18:42,840 --> 00:18:45,120 So they are cardiologists and I did my Ph.D. 342 00:18:45,120 --> 00:18:46,320 work with them. 343 00:18:46,320 --> 00:18:49,600 And when we were doing the work, we were starting to 344 00:18:49,680 --> 00:18:52,880 we actually focused in a lot on mesenchymal stem cells, 345 00:18:53,040 --> 00:18:57,000 and we later found that actually platelets are the ideal source. 346 00:18:57,000 --> 00:19:02,920 So we had a switch from mesenchymal stem cells to platelets, but the Ph.D. 347 00:19:02,920 --> 00:19:07,720 work lend itself to creating some of the research 348 00:19:07,720 --> 00:19:11,440 that went into the product design and 349 00:19:11,520 --> 00:19:15,880 and then I and I delivered the news that I'm going to become a dermatologist 350 00:19:15,960 --> 00:19:19,760 and my cardiologist, advisors and mentors were happy 351 00:19:19,760 --> 00:19:24,600 because they had come up with a product that would could be topically applied. 352 00:19:24,600 --> 00:19:27,120 And so part of it is right place at the right time. 353 00:19:27,120 --> 00:19:30,400 But I've spent about, I would say, 12 years 354 00:19:30,400 --> 00:19:34,120 learning the science, everything starting from Ph.D. 355 00:19:34,160 --> 00:19:37,920 to to being in dermatology and then running the clinical trials. 356 00:19:37,920 --> 00:19:42,120 So I've really seen that science evolve and really mature, 357 00:19:42,320 --> 00:19:44,760 and it's been very exciting because the shift has really gone 358 00:19:44,760 --> 00:19:48,960 from stem cells to exosomes, which is really self free. 359 00:19:49,040 --> 00:19:50,960 That's, that's, that's what we're hearing. 360 00:19:50,960 --> 00:19:54,760 And despite some of the concerns, which I'm glad we were able to address, 361 00:19:54,840 --> 00:19:58,360 you know, I've talked to a lot of doctors who who, like I said, 362 00:19:58,440 --> 00:20:03,760 are very supportive of this and do see these types of results. 363 00:20:03,840 --> 00:20:06,480 So let let's talk a little bit about plated, 364 00:20:06,480 --> 00:20:09,640 because there's, I think, three different products. 365 00:20:09,720 --> 00:20:10,960 I've got two of them here. 366 00:20:10,960 --> 00:20:14,840 One is the Daily Sarah, one is the intense serum. 367 00:20:14,920 --> 00:20:16,520 What are these meant for Who 368 00:20:16,520 --> 00:20:20,320 who were these meant for and what are some of the results that you've been seeing? 369 00:20:20,400 --> 00:20:20,960 Absolutely. 370 00:20:20,960 --> 00:20:25,240 So I can start by kind of sharing with what we found in our clinical study, 371 00:20:25,320 --> 00:20:28,760 which is that the product really works on a very individualized, 372 00:20:28,840 --> 00:20:30,240 personalized level. 373 00:20:30,240 --> 00:20:34,000 So if you start with greater redness or greater hyperpigmentation, 374 00:20:34,160 --> 00:20:35,720 that's where it's going to target. 375 00:20:35,720 --> 00:20:38,520 And so this is kind of the holy grail of how can one product 376 00:20:38,520 --> 00:20:42,000 do all these different facets of skin aging and skin biology? 377 00:20:42,000 --> 00:20:44,000 Well, it's because you're targeting the root 378 00:20:44,000 --> 00:20:46,680 cause of skin aging and the root cause of damage. 379 00:20:46,680 --> 00:20:50,520 So if you kind of help the body, give it the right signals to repair, 380 00:20:50,520 --> 00:20:54,440 it's going to repair what the damage to the damage that's been there already. 381 00:20:54,440 --> 00:20:56,800 So if it's redness, it targets redness. 382 00:20:56,800 --> 00:21:01,720 If it's brown pigmentation or size of fine lines, wrinkles, it targets that. 383 00:21:01,800 --> 00:21:04,560 And we're seeing those changes that as early as six weeks. 384 00:21:04,560 --> 00:21:08,800 So we use the busiest software to evaluate patients, 385 00:21:08,800 --> 00:21:12,000 everyone from the age 40 to 85. 386 00:21:12,000 --> 00:21:14,640 So we have a whole big group of patients. 387 00:21:14,640 --> 00:21:16,360 Average age was 54. 388 00:21:16,360 --> 00:21:18,240 Now, the two products that you have there. 389 00:21:18,240 --> 00:21:19,760 So let's talk about how we use it. 390 00:21:19,760 --> 00:21:25,200 So product number one is the plated gold, which is the plated intense. 391 00:21:25,280 --> 00:21:28,560 That's the product that we used in the clinical study. 392 00:21:28,600 --> 00:21:30,920 So the plated, intense, 393 00:21:31,000 --> 00:21:33,080 applied twice daily 394 00:21:33,080 --> 00:21:36,760 helps repair moderate to severe photo aging. 395 00:21:36,760 --> 00:21:40,200 So this is really meant for you to use 396 00:21:40,200 --> 00:21:43,800 in the summer time or with significant sun damage. 397 00:21:43,800 --> 00:21:50,120 So this is going to be targeting that considerable damaged skin, actinic damage, 398 00:21:50,200 --> 00:21:53,080 anything that you know, post laser like you talked about, 399 00:21:53,080 --> 00:21:56,120 if you have more concerns or even three laser. 400 00:21:56,120 --> 00:21:59,280 So I actually prime my patients with plated gold 401 00:21:59,280 --> 00:22:03,840 before they come in for their CO2 ablative laser or another type of laser. 402 00:22:03,840 --> 00:22:07,760 And I say use this product twice daily for six weeks that primes the skin 403 00:22:07,960 --> 00:22:09,120 and then you're going to get better 404 00:22:09,120 --> 00:22:13,080 results from a CO2 or any other laser that you're kind of looking into. 405 00:22:13,160 --> 00:22:15,720 So I love that gold for that purpose. 406 00:22:15,720 --> 00:22:16,640 Is this also good? 407 00:22:16,640 --> 00:22:18,960 You know, I mean, now we are in the colder months 408 00:22:18,960 --> 00:22:21,160 when a lot of people are going for those laser treatments. 409 00:22:21,160 --> 00:22:22,680 Is this is this what you want to use? 410 00:22:22,680 --> 00:22:25,680 If you've had something like you said, you can prime your skin before, 411 00:22:25,760 --> 00:22:27,680 Would you also use this after? 412 00:22:27,680 --> 00:22:28,320 Absolutely. 413 00:22:28,320 --> 00:22:32,080 We have a product called Plated Calm, which is meant specifically 414 00:22:32,080 --> 00:22:35,520 for post procedure, but those are interchangeable. 415 00:22:35,520 --> 00:22:37,320 And to a certain degree. 416 00:22:37,320 --> 00:22:40,120 So you can if you don't have the come with you, 417 00:22:40,120 --> 00:22:43,400 you can certainly use the plated intense for that purpose. 418 00:22:43,480 --> 00:22:44,160 I have to tell you. 419 00:22:44,160 --> 00:22:48,840 So, you know, I did the lab I used L-O-V-E for quite some time. 420 00:22:48,840 --> 00:22:52,320 And what I noticed for me was a lot more of the clarity, a lot of the 421 00:22:52,400 --> 00:22:55,240 not that I had very, very red skin, but that's where I noticed 422 00:22:55,240 --> 00:22:56,680 the biggest difference. 423 00:22:56,680 --> 00:23:00,240 But one of the things we were honest about was it had a certain smell. 424 00:23:00,320 --> 00:23:04,000 This does not this is not as 425 00:23:04,080 --> 00:23:06,200 Yes. It's not. 426 00:23:06,200 --> 00:23:08,160 As that. And it does have a really nice texture. 427 00:23:08,160 --> 00:23:09,080 I think I just put it on. 428 00:23:09,080 --> 00:23:12,080 It's kind of like a gel jelly. 429 00:23:12,200 --> 00:23:14,960 But, you know, he talked about one of the things that he talked about 430 00:23:14,960 --> 00:23:15,920 when we did this with Dr. 431 00:23:15,920 --> 00:23:17,280 Blues was how hard it is 432 00:23:17,280 --> 00:23:21,720 to keep that shelf stable because Exosomes are are fragile. 433 00:23:21,800 --> 00:23:25,720 How have you managed to do that with Plated? Yes. 434 00:23:25,720 --> 00:23:27,960 And this is again, goes back to sourcing. 435 00:23:27,960 --> 00:23:31,520 If you are able to isolate the product and are sourced 436 00:23:31,520 --> 00:23:36,480 in a way that the exosomes are stable, you can keep them shelf stable 437 00:23:36,560 --> 00:23:38,920 and and it should last year. 438 00:23:38,920 --> 00:23:43,000 So when the time the product is manufactured, we have up to two years 439 00:23:43,080 --> 00:23:45,880 that it can remain shelf stable for. 440 00:23:45,880 --> 00:23:48,280 But the studies and if you're using it consistently, 441 00:23:48,280 --> 00:23:50,000 even from the study that we did twice 442 00:23:50,000 --> 00:23:53,080 daily application at six weeks, that takes you through one bottle. 443 00:23:53,280 --> 00:23:57,560 So technically you don't want to have this in your drawer for too long 444 00:23:57,560 --> 00:24:00,920 because you want to be applying it to get the effect. 445 00:24:01,000 --> 00:24:05,280 But if you if you do have it, it also is okay because of the source, 446 00:24:05,400 --> 00:24:10,960 because of the manufacturing and the way that it is kept intact. 447 00:24:10,960 --> 00:24:14,640 So I kind of do sometimes use the example of of an egg. 448 00:24:14,800 --> 00:24:16,600 So if you think about an egg and it's 449 00:24:16,600 --> 00:24:19,680 kind of kept at room temperature and is kept on your counter, 450 00:24:19,800 --> 00:24:23,080 it can it can remain stable because the outer shell is intact. 451 00:24:23,280 --> 00:24:27,360 But if you crack that egg, then that egg is immediately not viable. 452 00:24:27,440 --> 00:24:30,360 You have to get rid of it or less than you know. 453 00:24:30,360 --> 00:24:33,520 So that's that goes into the consideration of 454 00:24:33,520 --> 00:24:38,120 is the exosome outer shell damaged or is it intact? 455 00:24:38,200 --> 00:24:39,160 Okay. 456 00:24:39,160 --> 00:24:42,760 And then we've got the daily serum, so “Calm” is for which I don't have here 457 00:24:42,840 --> 00:24:46,120 is specifically for post-treatment. 458 00:24:46,200 --> 00:24:50,160 But really you could use any of these, but you do have one that's targeted 459 00:24:50,160 --> 00:24:51,600 specifically for post treatment. 460 00:24:51,600 --> 00:24:53,320 What about the daily? 461 00:24:53,320 --> 00:24:56,080 So the Daily I love the daily for two types of users. 462 00:24:56,080 --> 00:25:00,840 One is for our younger patients who are considering this prejuvenation concept. 463 00:25:01,040 --> 00:25:03,800 They want to have something where they're getting ahead of it. 464 00:25:03,800 --> 00:25:08,320 You know, it's a little bit less of two X compared to the four X, 465 00:25:08,320 --> 00:25:10,800 so that the concentration is a little bit less, 466 00:25:10,800 --> 00:25:13,800 it's a little bit more hydrating in the sense too. 467 00:25:14,040 --> 00:25:18,680 And so you can you can see how that is so beautifully applied. 468 00:25:18,680 --> 00:25:21,840 And it goes on very nicely glides on. 469 00:25:21,840 --> 00:25:23,520 I love this product. 470 00:25:23,520 --> 00:25:26,760 In fact, I recently had a baby and I. 471 00:25:26,960 --> 00:25:28,680 Congratulations. 472 00:25:28,680 --> 00:25:29,600 Thank you. 473 00:25:29,600 --> 00:25:30,240 So plaited 474 00:25:30,240 --> 00:25:34,280 daily has been my go to for my stretch marks which has worked beautifully. 475 00:25:34,280 --> 00:25:39,400 So that's another area that you know because you can get more spread with it. 476 00:25:39,480 --> 00:25:42,520 So it's it's great for the younger patient and I would even say 477 00:25:42,520 --> 00:25:44,400 the postpartum patient. 478 00:25:44,400 --> 00:25:46,320 That's amazing to hear. And you know what? 479 00:25:46,320 --> 00:25:47,160 I love that you brought that up 480 00:25:47,160 --> 00:25:51,280 because so many things are marketed for our our face and we think face only. 481 00:25:51,280 --> 00:25:54,400 But yeah, of course, if you've got stretch marks, I'm 482 00:25:54,400 --> 00:25:58,720 sure like post scarring, that wound repair is probably 483 00:25:58,800 --> 00:26:01,600 going to be very beneficial too. 484 00:26:01,600 --> 00:26:04,600 So, you know, we have to mention price but I think, you know, 485 00:26:04,600 --> 00:26:09,520 these, these range from what I think this is in the two hundreds. Yes. 486 00:26:09,520 --> 00:26:12,400 And this will be variable based on your dispenser. 487 00:26:12,400 --> 00:26:15,520 But yes, that's about what we see. Okay. 488 00:26:15,760 --> 00:26:18,280 And then the daily. 489 00:26:18,280 --> 00:26:20,960 It's priced similarly and that's 490 00:26:20,960 --> 00:26:25,720 because you're getting the volume there is a little bit more. 491 00:26:25,800 --> 00:26:27,120 Yep. Yep. 492 00:26:27,120 --> 00:26:31,800 But both and I was like you said, it should last like six six weeks. Yes. 493 00:26:31,800 --> 00:26:33,360 And if you're consistently applying it. 494 00:26:33,360 --> 00:26:37,120 So the way that I apply, if you start with a goal, so I kind of use 495 00:26:37,120 --> 00:26:40,640 the gold as pulsing because it's going to deliver really good signals. 496 00:26:40,800 --> 00:26:41,760 So you want to pulse 497 00:26:41,760 --> 00:26:44,760 with the gold twice daily for six weeks, then you're going to achieve this 498 00:26:44,760 --> 00:26:48,080 beautiful maximal effect, glowing skin, all the good stuff. 499 00:26:48,320 --> 00:26:52,200 Then you can switch to the daily and you can go three times a week 500 00:26:52,200 --> 00:26:56,320 or once a day, whatever, to kind of maintain that effect. 501 00:26:56,320 --> 00:26:58,600 And then you can go again with the gold. 502 00:26:58,600 --> 00:27:00,520 And after a month or so. 503 00:27:00,520 --> 00:27:03,080 So just kind of using the gold intermittently, 504 00:27:03,080 --> 00:27:05,520 this is for the average user, right? 505 00:27:05,520 --> 00:27:09,080 For for more mature skin, I say just stick with the gold for younger skin. 506 00:27:09,080 --> 00:27:11,560 I could say stick with the daily, but if you kind of want to, 507 00:27:11,560 --> 00:27:14,960 if you're in the middle and you're kind of wanting to get a bit of benefits 508 00:27:14,960 --> 00:27:19,800 of both, you can do it that way where you kind of pose with the 509 00:27:19,880 --> 00:27:23,280 skin cycle, with the gold or the intense, 510 00:27:23,480 --> 00:27:26,480 and then go back to the daily for maintenance. 511 00:27:26,720 --> 00:27:30,320 And you said you're going to be publishing clinical your clinical trials 512 00:27:30,320 --> 00:27:33,960 for the gold with the Visio before and after. 513 00:27:34,040 --> 00:27:36,960 The we've already published that of the esthetic surgery journal. 514 00:27:36,960 --> 00:27:39,280 So we do have those results out. 515 00:27:39,280 --> 00:27:42,800 We have submit and we also have results for the hand. 516 00:27:42,800 --> 00:27:45,800 So I love that you brought up other areas that you can treat self 517 00:27:45,800 --> 00:27:47,160 with the back of the hand. 518 00:27:47,160 --> 00:27:47,520 Yeah. 519 00:27:47,520 --> 00:27:50,680 So we we recently published that study as well 520 00:27:50,760 --> 00:27:53,840 in the Plastic and reconstructive surgery journal where you can see 521 00:27:53,840 --> 00:27:56,840 that is has had considerable improvement in brown spots 522 00:27:56,840 --> 00:28:00,800 especially because it does have that antioxidant effect. 523 00:28:00,880 --> 00:28:05,480 So it does both where it kind of is antioxidant but also builds collagen. 524 00:28:05,560 --> 00:28:08,160 Man, you have to link to those on the website. 525 00:28:08,160 --> 00:28:09,440 So that's all I'm going to say is 526 00:28:09,440 --> 00:28:12,560 I would say link that out because I think that that is very compelling. 527 00:28:12,560 --> 00:28:16,040 And for people who are looking for this type of skin care, 528 00:28:16,120 --> 00:28:20,360 the science matters, the research matters, the results matter. 529 00:28:20,440 --> 00:28:21,560 You know, I always tell 530 00:28:21,560 --> 00:28:26,080 people and I'm sure you can say this as a dermatologist, you have to manage 531 00:28:26,080 --> 00:28:31,440 expectations when it comes to sort of these these miracle creams. 532 00:28:31,440 --> 00:28:34,320 Right. Because I don't know. 533 00:28:34,320 --> 00:28:35,000 Do you agree with me? 534 00:28:35,000 --> 00:28:36,360 I feel like you're never going to get in a bottle. 535 00:28:36,360 --> 00:28:39,240 What you're going to get from a laser, what you're going to get from a knife. 536 00:28:39,240 --> 00:28:41,160 So manage expectations. 537 00:28:41,160 --> 00:28:43,200 But from what I saw from some of the before and after, 538 00:28:43,200 --> 00:28:46,520 they were very compelling in terms of fine lines and wrinkles. 539 00:28:46,600 --> 00:28:49,600 Hyperpigmentation and certainly with redness. 540 00:28:49,720 --> 00:28:50,320 Absolutely. 541 00:28:50,320 --> 00:28:54,120 And I think redness really like knocked it out of the park, 542 00:28:54,120 --> 00:28:59,520 which is where I have actually replaced my laser with this product. 543 00:28:59,600 --> 00:29:01,000 The PDF laser, the pulse eye 544 00:29:01,000 --> 00:29:04,840 laser is what I use for my patients with rosacea or facial redness. 545 00:29:05,040 --> 00:29:08,440 And now what I've done is that I provide my patients 546 00:29:08,440 --> 00:29:11,440 with the bladed intents and have them use it after, 547 00:29:11,440 --> 00:29:17,080 and they're just coming in maybe twice a year for their PDF laser 548 00:29:17,160 --> 00:29:19,680 instead of once every three months. 549 00:29:19,680 --> 00:29:21,080 Amazing. That was going to my next question. 550 00:29:21,080 --> 00:29:24,280 So for people with sensitive skin with rosacea 551 00:29:24,360 --> 00:29:27,880 is this this is something you'd recommend? 552 00:29:27,960 --> 00:29:29,240 Yes, definitely recommend. 553 00:29:29,240 --> 00:29:30,000 It's not 554 00:29:30,000 --> 00:29:33,520 it wasn't tested for that indication, but we know that redness 555 00:29:33,520 --> 00:29:34,600 considerably improves. 556 00:29:34,600 --> 00:29:37,960 So I love using it for that patient population here. 557 00:29:38,040 --> 00:29:38,520 Great. 558 00:29:38,520 --> 00:29:41,600 And thank you for being specific about, you know, the claims that you can 559 00:29:41,600 --> 00:29:43,600 and cannot make with this. 560 00:29:43,680 --> 00:29:47,520 So what is next now inflated? 561 00:29:47,680 --> 00:29:52,080 Is there are there new exciting things on the frontier for you? 562 00:29:52,160 --> 00:29:55,400 Yes. So first, I'm very excited that the product is the first 563 00:29:55,400 --> 00:29:59,280 and only now of renewable and recyclable products. 564 00:29:59,280 --> 00:30:03,920 So it's a clean brand of the new packaging which we'll send to you 565 00:30:04,080 --> 00:30:07,280 is actually uses reusable inserts. 566 00:30:07,400 --> 00:30:11,280 So actually eliminating a lot of the waste and kind of becoming 567 00:30:11,280 --> 00:30:15,640 the first physician dispense product that is truly 568 00:30:15,720 --> 00:30:18,960 green initiative and and hopefully will continue 569 00:30:18,960 --> 00:30:21,960 to inspire other brands to do the same. 570 00:30:22,080 --> 00:30:23,680 So that's very exciting for us. 571 00:30:23,680 --> 00:30:28,560 The second thing is looking at here, so developing a hair scalp serum, 572 00:30:28,640 --> 00:30:32,160 we know that the product is able to penetrate through the skin. 573 00:30:32,160 --> 00:30:36,600 So you would have the same type of effects in the hair and we're kind of 574 00:30:36,680 --> 00:30:39,520 getting ready to launch that product this year. 575 00:30:39,520 --> 00:30:41,000 Very, very exciting. 576 00:30:41,000 --> 00:30:43,200 I want to thank you so much, Doctor Wyles. 577 00:30:43,200 --> 00:30:45,800 If people want to know more about Plated, 578 00:30:45,800 --> 00:30:48,280 if they want to purchase it, where can they go? 579 00:30:48,280 --> 00:30:50,800 They can go to plated skin science 580 00:30:50,800 --> 00:30:55,200 dot com and and get more information. 581 00:30:55,440 --> 00:30:57,240 They can purchase it. 582 00:30:57,240 --> 00:31:01,080 Also, there's several physician offices that are dispensing the products. 583 00:31:01,080 --> 00:31:05,640 So just ask your local dermatologist and if you can't find it, follow us 584 00:31:05,640 --> 00:31:09,680 on Instagram at plated skin science and we'll be able to connect you. 585 00:31:09,760 --> 00:31:10,480 And what about you? 586 00:31:10,480 --> 00:31:13,280 If we want to follow what you're up to, you know, 587 00:31:13,280 --> 00:31:16,680 is there a way that we can do that maybe through the Mayo Clinic? 588 00:31:16,760 --> 00:31:20,600 Yes, certainly You can go on the Mayo Clinic and find my profile. 589 00:31:20,600 --> 00:31:23,800 And we definitely do post more information about our lab. 590 00:31:23,800 --> 00:31:26,080 We are 3D bioprinting skin. 591 00:31:26,080 --> 00:31:28,640 We're understanding skin cells, senescence. 592 00:31:28,640 --> 00:31:30,440 So there's a lot of exciting things. 593 00:31:30,440 --> 00:31:32,360 You can also follow me on, Dr. 594 00:31:32,360 --> 00:31:37,080 Wyles, w yl e s dot derm on Instagram. 595 00:31:37,160 --> 00:31:37,680 Amazing. 596 00:31:37,680 --> 00:31:40,200 I want to just thank you so much for your time. 597 00:31:40,200 --> 00:31:42,920 Clearly, you have dedicated your life to this 598 00:31:42,920 --> 00:31:45,920 and I think that you were really able to shed some light 599 00:31:45,920 --> 00:31:49,840 on some of the confusion that might be surrounding Exosomes. 600 00:31:49,840 --> 00:31:54,960 I look forward to seeing what's going to happen in this sort of new, 601 00:31:55,040 --> 00:31:57,360 I don't know, the future of skincare. 602 00:31:57,360 --> 00:31:59,800 It's always changing. It's always getting more exciting. 603 00:31:59,800 --> 00:32:02,520 If you at home have any questions you want me to pass on to Dr. 604 00:32:02,520 --> 00:32:03,720 Wyles, I'm happy to do so. 605 00:32:03,720 --> 00:32:06,920 You can email me at Hello at Art Beauty podcast dot com. 606 00:32:07,000 --> 00:32:12,080 You can find us on Facebook, Instagram and YouTube @ArtBeautyPodcast, 607 00:32:12,160 --> 00:32:15,880 and as always, we will see you next Tuesday. 608 00:32:15,960 --> 00:32:20,000 Hopefully just feeling a little bit more educated. Bye!