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This is the Art Beauty podcast,
where we are always reaching for truth

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and beauty.
Remember the brands on the show?

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We're not paying to be here,
so we get to asking the questions

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that you want answered
because you deserve to be informed

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so you can make the best choices
for yourself.

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With that said, I'm in today.

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My fabulous co-host is Chris Mirabile.

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He is the founder of NOVOS
He is a biohacker,

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has an incredible story,
an entrepreneur, a brain tumor survivor.

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So we are going
to hear all about his journey.

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And then also he's going to tell us
a little bit about

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aging and this concept of aging

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and biohacking, which I know
that you are as interested in as I am.

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So with that
said, we've got a lot to cover today.

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Let's get right into it.

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Chris, welcome to the show.

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Thank you,
Amber. It's a pleasure to be here.

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So, you know, I have to say,

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before we even get started,
you have such an incredible background.

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Could you maybe tell a little bit
about why

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you were so interested in health
in the first place?

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Sure.

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Well, it actually all began
when I was 12 years old.

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I saw an issue of Men's Health magazine
at the bookstore.

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And I decided at that moment
that I needed to focus on my health.

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I wanted to be attractive
to the girls in school.

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So I started exercising
and eating a healthy diet at 12 years out.

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Okay.

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And I did it every single day.

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I'd come home from school
and I would do pull ups on the pullup bar

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that my my father
installed in our basement and

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and it was it was all the more shock to me
that when I was 16 years old,

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I suddenly had a seizure while out
in on a school trip in New York City. And

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it turned
out that it was caused by a brain tumor.

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And so that was the moment
where my thinking completely shifted.

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And by my perception of health
evolved from one

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that was the superficial side of health,
of trying to be attractive and

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play sports.

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Well, to excuse me to one
in which I understood that health was

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was more complex than that was biology
and avoidance of disease.

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And so that's when I decided
that it would be important for me to

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try to focus on never laying in a hospital
bed again, contemplating mortality,

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at least until my final days,
hopefully a very long time from then.

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And that that started my journey
and planted the seed

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for what is now essentially
what I've created with no boss.

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I mean, so at 16 years old, to have such,

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you know, a brush with mortality,
it certainly is life changing.

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You know, for anybody who's out there
before we kind of move on.

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Do you have advice for something
that kind of got you through that time?

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Oh, you know, it's it's

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for me,
I chose I made a conscious decision

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to look at the experience as a gift, as

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a gift from which I can learn,

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see aspects of life
that others don't have the ability to see

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or at least won't see
until much later in their lives.

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So I tried to find all of the positives
that I could and reframe the experience

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rather than from a victim mindset of like,
why me?

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And the ways in which it may have hurt me
instead into an empowered mindset of

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what can I take out of this experience
and what can I what can they do with that?

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How can I lead live a better life
as a result of this?

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Now, was that recovery?
And I'm only asking.

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I had a good friend
who also at a very young age

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had a brain tumor
and and it was a really tough recovery.

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I mean, he lost a lot of his speech

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walking ability, which now has come back.

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But to be honest, not 100%.

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What was that like for you?

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For me, fortunately, I didn't really have
that many long term side effects.

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I'd say the number one was

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my memory.

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It was shot.

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I remember the first year this was going

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into Saturdays for college and

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and I had I had a tutor
who asked me to repeat a sentence

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that she had just read to me,
and I couldn't repeat the sentence.

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It was literally 2 seconds later
and I could not repeat the sentence.

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That's how bad my memory was.

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And I had gone from doing very well
in school and being in advanced classes

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to now being, you know,
at literally at the bottom of the rung,

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like struggling
to even just remember a sentence.

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So it was really humbling.

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And it taught me

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excuse me, it really taught me,

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show me another side of life, of of,
you know, disability and not being capable

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and really just opened my mind up

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in so many different ways,
made me more empathetic.

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And and that lasted for a while.

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Memory, you know, for for years probably.

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But the first year in particular,
especially

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with all of the anti-seizure medication
that I was prescribed

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by that first year,
it really slow me down a lot.

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I mean, I got to be honest,

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talking to you now and seeing you've had
some tremendous successes.

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You know,
you've also had some tremendous losses.

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I want to be mindful of the time here,
but I will say that you check out some of

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your other podcasts that you've been on
because you really have incredibly

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just an incredible entrepreneurial journey
to get to where you are now.

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Super inspiring.

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But, you know,

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you wouldn't be able to tell that you had
all of this hardship early on.

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So, you know, in terms of this idea
and sort of jumping forward,

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when you became interested in sort of
what can I do today

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to sort of take control of my health?

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You know, we've heard a lot
about this difference

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between a biological age
and chronological age,

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and that we can actually sort of
have a biological agent younger

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than our chronological age for people
who might not have be familiar with that.

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Can you explain what that is, what
our biological age is, what our chronic

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or chronic chronological age is, and how
we can sort of tell the difference?

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Yeah.

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So chronological age is
what we're all familiar with when we say,

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How old are you? Right.

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That's how many birthdays you've had.

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Biological age is something

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related
to how old our biological systems are,

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our cellular integrity,
their capacities and capabilities,

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and essentially that then leads to things
like your disease

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risk, your more mortality risk
and your ability to perform functions.

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Now I'll drive it home for people.

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I think that people can really relate
to this concept, this idea of

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everyone knows that 50 year old
who looks like they're 65 or 70

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and everyone knows that 50 year olds
who looks like they're 40

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or even maybe in their late thirties.

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And you question like, how is it possible
that that person is looking so young?

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And when you put those two people
next to each other, the older

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looking and younger looking person,
that's really a good picture of someone

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that most likely had an accelerated
biological pace of aging

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and someone who had a decelerated
biological pace of aging.

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What most people don't realize is

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I think people just assume
this is genetics.

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Like that person got lucky
or they have really good genes.

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The fact is that
researchers have found that 90% of

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your pace of aging is actually based
on your lifestyle and environment.

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It is not based on your genetics.

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It's only 10% of the equation.

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It's a little bit more

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maybe for like super centenarians, people
who live to 120 years old.

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But for for the vast majority of us,

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it's actually only 10%
or less that is coming from genetics.

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So I think that that's important.

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It's empowering for people to realize
you actually can do something about this.

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So those of us who are proactive,
people who like to

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to take charge in our lives and create
the lives that we want for ourselves,

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that's really important information
because now you can actually do

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something about it
and slow down the pace of aging.

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So for people who are out there

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wondering, like, well, wait a minute,
I feel super young,

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how can I actually tell
what my biological age is?

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What are our options out there?

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It's a great question.

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So there's multiple different ways
to do it.

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Scientists,
this is cutting edge science right now.

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This is literally like
I went to a science event

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just a month ago, and researchers
are presenting their newest

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biological age clocks
straight out of the university. So

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typically

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they're measuring what's known
as your epigenome.

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Now, it's
not always measuring the epigenome,

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but those are the most promising,
the most researched

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biological age
clocks in existence right now.

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And your epigenome is the layer
that sits right next to your genome

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or your genetics. Right.

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So everyone's familiar
with genes at this point.

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But what most people aren't familiar with
is that you have an epigenome, which is

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which genes are turned on and off.

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So if your genes are the piano keys,
the epigenome is the piano player

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determining
which genes or keys to play, right.

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And so as you age,
maybe when you're young,

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that the tune that's being played
is, you know, Tchaikovsky, right?

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It's a symphony.

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And then as you age,
certain keys are incorrectly pressed

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or they're missing the beat,
missing the rhythm.

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Right.

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So you're pressing the wrong keys
or you're missing keys and it no longer

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sounds like that perfect symphony
when you were younger.

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And there are patterns
to this specific genes in particular

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that these algorithms
that the scientists are creating

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can identify
and based on your biological age.

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So essentially, again, your risk of
of a disease and or mortality.

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They're able to create these algorithms
that will then tell you your equivalency.

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So if you are, for example,

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I can talk about myself
actually with this.

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So so I'm. Trying to brag.

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Time to brag, but I'll tell you why
I'm saying brag and admit it.

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But yes. Okay.

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So a humblebrag.

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So yeah, I'm 39 years old biologically,
I started chronologically,

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but biologically I'm more than 13 years

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younger than that, according
to not just one biological age clock,

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but I've done about a dozen of them
and I've taken the average of those.

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So that's basically
and there's there's a reason for that

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because some clocks
are more accurate than others.

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And we can talk about that if you care to.

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But there's like third generation clocks
that are the most accurate

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and then they're first generation clocks
that people are companies are also selling

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that are not particularly accurate,

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but sorry, go ahead.

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Yeah.

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So okay, so for everybody

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who's listening out there, I mean, look,
I have to be I'm turning 44 next week.

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I feel pretty good. I feel young.

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I took one of these tests
and I was convinced

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there's no way that I'm aging

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at a rate equivalent
to my chronological age.

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But it was it was exactly one I was aging.

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My pace of aging was one,
which means I am chronologically

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for it, while at the time it took it 43
and biologically 43.

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I was really bummed out about that.

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I got to be honest.

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And now in terms of the tests, I took, one
that was a saliva based test.

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I know that Novos has one
and I was looking into this today.

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That's a blood, you know, you do a little
drop of blood and you send that in.

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Do you think that there's a difference
in in the accuracy there?

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Yes, there definitely is.

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So blood based tests, as you might

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suspect,
are more accurate than saliva based tests.

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And so the blood based tests
that we offer it,

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you just prick your finger
and then you spread it on an index card

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within a little circle,
and then you ship that back to us.

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We offer three different tests in our kit.

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So it's called Noble's age.

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And within our kit we've got the
do you need and pace clock,

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which is the most advanced biological age
clock out there right now.

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It was created by researchers
at Columbia and Duke University's.

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We licensed it from them.

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And this is telling you
your rate of aging right now.

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So a one, as you mentioned
before, would mean every one

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chronological year
you're aging one biological year.

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Ideally, you get that to be less than one.

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Mine, for example, is 0.69.

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So that implies I'm aging 31% slower

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than the average person is per year.

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And we can talk about how how I believe
I achieve that if you'd like to later on.

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But that's the first test.

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And we think that
this is the most important one

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because this is telling you
your trajectory right now

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00:12:55,360 --> 00:12:58,800
based on your lifestyle,
are you accelerating your aging

238
00:12:58,800 --> 00:13:02,520
like maybe aging 1.2,
so 20% faster than average?

239
00:13:02,760 --> 00:13:05,040
Or are you aging slower than average?

240
00:13:05,040 --> 00:13:08,120
And this is also
one of the most sensitive tests to change.

241
00:13:08,120 --> 00:13:12,520
So in as little as 3 to 6 months,
based on your lifestyle changes,

242
00:13:12,600 --> 00:13:15,880
you can
then see those those scores changing.

243
00:13:15,960 --> 00:13:19,400
The second test we offer is biological age

244
00:13:19,480 --> 00:13:22,200
that is less sensitive to change.

245
00:13:22,200 --> 00:13:23,760
There are other companies out
there as well.

246
00:13:23,760 --> 00:13:27,600
So in biological age clocks,
they're not as accurate and as precise

247
00:13:27,600 --> 00:13:30,600
as that pace of aging is quite yet.

248
00:13:30,720 --> 00:13:34,800
So we we tell our customers
to take it with a grain of salt.

249
00:13:34,800 --> 00:13:40,200
If you're looking at the kid overall,
we say put 85% of

250
00:13:40,200 --> 00:13:43,960
of your focus
on that you need and pace clock

251
00:13:44,040 --> 00:13:49,160
and maybe you know 5 to 10%
in the biological age and that's going to

252
00:13:49,160 --> 00:13:55,040
include related aging throughout your life
lifetime like maybe you had

253
00:13:55,120 --> 00:13:56,880
a traumatic

254
00:13:56,880 --> 00:14:00,480
childhood for example
has has been found to accelerate aging

255
00:14:00,480 --> 00:14:03,760
and that could be found
even in the later decades of your life.

256
00:14:03,840 --> 00:14:07,760
And then the third test
that we offer is telomere length.

257
00:14:07,760 --> 00:14:11,000
This is included in that Noble's age
kid, and telomeres

258
00:14:11,000 --> 00:14:14,280
are the end caps of your chromosomes.

259
00:14:14,280 --> 00:14:19,560
They protect your DNA, and those
get shorter every time your cells divide.

260
00:14:19,640 --> 00:14:24,000
But they can also be lengthened
by different foods and healthy habits

261
00:14:24,000 --> 00:14:24,920
and so on.

262
00:14:24,920 --> 00:14:29,520
And so for this test, it's not a direct
marker of your biological age,

263
00:14:29,520 --> 00:14:33,520
but what you want to make sure of is that
your telomeres don't get too short.

264
00:14:33,600 --> 00:14:37,000
If they get too short,
then you have a higher risk of different

265
00:14:37,000 --> 00:14:40,880
diseases of aging like forms, certain
forms of cancer and so on.

266
00:14:40,960 --> 00:14:42,560
So it's more of a check off the box.

267
00:14:42,560 --> 00:14:45,480
They're not too short.
Okay, I can rest easy at night.

268
00:14:45,480 --> 00:14:48,840
So those are the three tests
that we offer in our age. Kit.

269
00:14:48,920 --> 00:14:52,000
You know, I want to go back to something
you said before because, you know,

270
00:14:52,000 --> 00:14:53,280
I keep it real with everybody here.

271
00:14:53,280 --> 00:14:54,680
I'm super fascinated in this.

272
00:14:54,680 --> 00:14:58,080
But I think, you know, in

273
00:14:58,160 --> 00:14:58,440
in the

274
00:14:58,440 --> 00:15:01,800
general, you know, society,
this is a little bit fringe still, right?

275
00:15:01,800 --> 00:15:06,000
This idea of biohacking,
this idea of, you know,

276
00:15:06,080 --> 00:15:10,840
being able to sort of manipulate
our biological age and sort of turn back

277
00:15:10,840 --> 00:15:14,120
our biological age is something
that, you know,

278
00:15:14,200 --> 00:15:17,760
not if you're a billionaire tech person
right there doing it all the time,

279
00:15:17,760 --> 00:15:20,640
but for the most of us,
this is relatively new

280
00:15:20,640 --> 00:15:23,680
and it does come at a cost,
right, to these tests are not inexpensive.

281
00:15:23,680 --> 00:15:25,720
They're what, ballpark?

282
00:15:25,720 --> 00:15:27,600
$300.

283
00:15:27,600 --> 00:15:30,480
If you buy two kits, it's $300 per
kit for most.

284
00:15:30,480 --> 00:15:32,480
If you buy just one, it's 349.

285
00:15:32,480 --> 00:15:32,800
Okay.

286
00:15:32,800 --> 00:15:38,280
So, you know, it's certainly
something that, you know, but I would say.

287
00:15:38,280 --> 00:15:39,880
Costs will. Come down.

288
00:15:39,880 --> 00:15:41,440
Right? Costs will come down in the future.

289
00:15:41,440 --> 00:15:41,680
Right.

290
00:15:41,680 --> 00:15:44,560
So just like any other technology,
when you first start,

291
00:15:44,560 --> 00:15:45,960
the cost is is higher.

292
00:15:45,960 --> 00:15:48,320
And as time progresses,
the costs will go down.

293
00:15:48,320 --> 00:15:50,480
And and we'd like to provide
that to customers.

294
00:15:50,480 --> 00:15:52,920
But to your point
about tech billionaires and,

295
00:15:52,920 --> 00:15:56,600
you know, trying to hack their aging,
that's what the press loves to cover.

296
00:15:56,600 --> 00:16:00,440
But we as a company know goes
we're a public benefit corporation

297
00:16:00,520 --> 00:16:04,120
with my my childhood experience
or my teenage experience.

298
00:16:04,200 --> 00:16:07,000
It's very important to me to

299
00:16:07,000 --> 00:16:11,320
to be able to offer to to the public
the ability to,

300
00:16:11,400 --> 00:16:15,680
first of all, the knowledge to understand
that aging is in your hands.

301
00:16:15,680 --> 00:16:19,200
You can control the rate
at which you are aging too,

302
00:16:19,240 --> 00:16:22,160
with within certain
limitations, of course.

303
00:16:22,240 --> 00:16:24,200
And and with that knowledge

304
00:16:24,200 --> 00:16:28,480
give you free ways
to be able to slow down your aging.

305
00:16:28,480 --> 00:16:32,680
So to the point about the, you know, the
the expense of the biological age kit.

306
00:16:32,760 --> 00:16:33,840
Yes, of course.

307
00:16:33,840 --> 00:16:37,240
Like if you are really getting into it,
you might want to make that investments.

308
00:16:37,240 --> 00:16:41,040
But even if you don't, we provide
very practical guidelines for things

309
00:16:41,040 --> 00:16:45,360
that you can do in your everyday life,
from your diet to your exercise,

310
00:16:45,360 --> 00:16:48,600
to your sleep routine
to your strategy meeting, go down

311
00:16:48,600 --> 00:16:52,000
the list of the things that science
has shown.

312
00:16:52,080 --> 00:16:55,840
Exhibit
positive effects on your biological age

313
00:16:55,840 --> 00:16:57,560
and biological rate of aging,

314
00:16:57,560 --> 00:16:59,760
and you can do that
completely for free on our website.

315
00:16:59,760 --> 00:17:02,760
In fact, something that your listeners
might be really interested in

316
00:17:02,960 --> 00:17:05,880
is we offer a free tool called Face Age.

317
00:17:05,880 --> 00:17:10,320
This is a
you take a selfie, it's AI powered,

318
00:17:10,320 --> 00:17:15,160
and the artificial intelligence
is going to evaluate your selfie

319
00:17:15,360 --> 00:17:19,240
and tell you how young your face looks,
how young your AI age is.

320
00:17:19,280 --> 00:17:22,280
And then other skin health markers
like wrinkles,

321
00:17:22,560 --> 00:17:25,560
skin redness, pore size, etc.

322
00:17:25,560 --> 00:17:29,240
And then we give you practical guidance
for improving all of those scores.

323
00:17:29,320 --> 00:17:31,760
And you can track this over time,
of course.

324
00:17:31,760 --> 00:17:32,960
Right.

325
00:17:32,960 --> 00:17:36,600
So so that's that's one thing that that
a lot of people are really interested in.

326
00:17:36,600 --> 00:17:39,520
And then we also have on our website
a quiz that you can access

327
00:17:39,520 --> 00:17:43,080
at the top of the website
where you just answer a questionnaire

328
00:17:43,280 --> 00:17:47,600
and then we give you personalized
recommendations for what you based on

329
00:17:47,600 --> 00:17:51,520
your lifestyle, need to focus on
most to slow down your pace of aging.

330
00:17:51,760 --> 00:17:55,920
None of this cost a sense we pay for it
out of our pocket as a public

331
00:17:55,920 --> 00:17:59,640
benefit corporation and then, of course,
we hope some of you turn into customers.

332
00:17:59,720 --> 00:18:03,280
But regardless,
we want to provide this to the public.

333
00:18:03,320 --> 00:18:04,680
I want to backtrack on what I said before.

334
00:18:04,680 --> 00:18:08,520
So I will say, like I did one
of these biologics that's not from Novo,

335
00:18:08,640 --> 00:18:12,280
although I am interested in trying
yours out, because the one that I did was

336
00:18:12,360 --> 00:18:17,360
that was a saliva based,
but it did give markers for various areas.

337
00:18:17,360 --> 00:18:19,960
So my brain, my liver,

338
00:18:20,040 --> 00:18:21,200
my metabolism

339
00:18:21,200 --> 00:18:24,200
of of where that biological age was.

340
00:18:24,200 --> 00:18:27,200
And I will tell you, it, it, it, it was

341
00:18:27,200 --> 00:18:30,400
it was good enough to start me

342
00:18:30,480 --> 00:18:32,440
on the road to some better habits.

343
00:18:32,440 --> 00:18:35,080
So like, my liver was a little bit older.
Well, guess what?

344
00:18:35,080 --> 00:18:38,120
You know, you've heard me talk about,
like those nightly tequila drinks.

345
00:18:38,280 --> 00:18:39,240
I had to give those up.

346
00:18:39,240 --> 00:18:42,320
That was kind of a bummer, but,
you know, so it's good to kind of

347
00:18:42,320 --> 00:18:45,640
have that as a marker for good behavior.

348
00:18:45,640 --> 00:18:49,920
I think if you're ready to sort of take
on some sort of a big change in your life,

349
00:18:49,920 --> 00:18:51,960
if you're about to embark
on a fitness journey,

350
00:18:51,960 --> 00:18:57,040
if maybe you had some sort of a
health scare that you need to

351
00:18:57,120 --> 00:18:59,080
change your behaviors.

352
00:18:59,080 --> 00:19:03,120
I always think it's a it's a great idea
to kind of have this as a baseline.

353
00:19:03,120 --> 00:19:05,640
And then how often do people normally
take these?

354
00:19:05,640 --> 00:19:06,600
Is it every six months?

355
00:19:06,600 --> 00:19:08,680
Every year? Every two years.

356
00:19:08,680 --> 00:19:12,160
So so if we were trying
to maximize profit, we would say

357
00:19:12,160 --> 00:19:13,280
take it every three months.

358
00:19:13,280 --> 00:19:18,600
But the truth is, I suggest that
everyone consider taking it once a year.

359
00:19:18,680 --> 00:19:21,280
The reason
being that you have to think of yourself

360
00:19:21,280 --> 00:19:26,520
as an end equals one scientific experiment
and being number of participants, right?

361
00:19:26,520 --> 00:19:30,280
Like one participant in this scientific
experiment and that participant is you.

362
00:19:30,360 --> 00:19:33,840
So you have a very different

363
00:19:33,840 --> 00:19:37,520
lifestyle in the winter,
let's just say before Christmas

364
00:19:37,520 --> 00:19:42,800
than you do in the summer, let's say
for July 4th weekends, right? And

365
00:19:42,880 --> 00:19:43,360
different

366
00:19:43,360 --> 00:19:48,240
amounts of time outdoors
with UV radiation, physical exercise,

367
00:19:48,240 --> 00:19:49,240
different diets,

368
00:19:49,240 --> 00:19:53,480
different drinking habits,
different stress levels go down the list.

369
00:19:53,560 --> 00:19:56,400
And those are known in science
as confounding factors.

370
00:19:56,400 --> 00:20:00,200
These can all kind of mess up
the results and

371
00:20:00,280 --> 00:20:02,240
and lead you to false

372
00:20:02,240 --> 00:20:05,720
conclusions like, oh,
maybe the lifestyle that they changed

373
00:20:05,720 --> 00:20:09,360
to or the product that I'm using,
the supplement I'm using isn't working.

374
00:20:09,360 --> 00:20:12,720
Well, no, maybe it's actually that you're
a lot more stressed this time of year

375
00:20:12,880 --> 00:20:15,600
or you're not physically active
enough, Right?

376
00:20:15,600 --> 00:20:18,560
So to minimize confounding factors,
we suggest that

377
00:20:18,560 --> 00:20:22,280
you take the test at the same time
the following year.

378
00:20:22,360 --> 00:20:25,080
Now, if budget permits, of course,

379
00:20:25,080 --> 00:20:28,120
you can take it once every six months
or once every three months.

380
00:20:28,120 --> 00:20:30,480
I wouldn't do it more often than once
every three months.

381
00:20:30,480 --> 00:20:33,920
But once a year,
I think is a healthy balance for budget

382
00:20:34,160 --> 00:20:38,200
and for the value
that you can get out of taking in a test.

383
00:20:38,280 --> 00:20:40,800
Now, given that you just said,
you know, it's lifestyle,

384
00:20:40,800 --> 00:20:43,560
maybe you don't want to do this
on January 1st, right?

385
00:20:43,560 --> 00:20:46,000
So for all of my people who are like,
I'm starting something new,

386
00:20:46,000 --> 00:20:49,080
but coming out of those holidays
when you're probably, you know,

387
00:20:49,200 --> 00:20:52,000
drinking, partying,
maybe eating foods that you don't eat,

388
00:20:52,000 --> 00:20:54,800
maybe not the best time to take it.

389
00:20:54,880 --> 00:20:56,920
Yeah, probably take it to get one.

390
00:20:56,920 --> 00:21:01,200
That's like a better depiction
of what your real life is actually is.

391
00:21:01,280 --> 00:21:04,640
Now, the needle is not going to move in in
just like a day

392
00:21:04,800 --> 00:21:06,480
or two of unhealthy eating.

393
00:21:06,480 --> 00:21:10,240
But and so if you're if you're like me,
I eat pretty healthy most of the time.

394
00:21:10,240 --> 00:21:11,600
But then for Christmas,

395
00:21:11,600 --> 00:21:14,520
I might Christmas Eve and Christmas Day,
I might eat unhealthy.

396
00:21:14,520 --> 00:21:16,560
But I'm not I'm not doing that for weeks.

397
00:21:16,560 --> 00:21:17,920
I'm doing it for a day or two.

398
00:21:17,920 --> 00:21:20,920
That's not really going
to move the needle on the test.

399
00:21:21,120 --> 00:21:25,240
But for others who might like not eat
healthy and exercise for the whole month

400
00:21:25,240 --> 00:21:28,320
of December, let's say, yeah, maybe
wait a little bit longer.

401
00:21:28,320 --> 00:21:29,200
Also, keep in mind

402
00:21:29,200 --> 00:21:33,760
that if you were recently very sick, like,
yeah, COVID or the flu,

403
00:21:33,840 --> 00:21:37,200
you probably want to wait
at least a month before you take the test

404
00:21:37,200 --> 00:21:38,640
because your immune system

405
00:21:38,640 --> 00:21:42,440
and the inflammation in your body might
have an impact on the results as well,

406
00:21:42,520 --> 00:21:45,320
which is not commonly talked about,
but it's something that we suggest

407
00:21:45,320 --> 00:21:46,440
to customers.

408
00:21:46,440 --> 00:21:48,360
That's that's great to know.

409
00:21:48,360 --> 00:21:51,320
You know, so
so given this now that we've covered

410
00:21:51,320 --> 00:21:56,160
the fact that we can have a different
biological age, that we can control that

411
00:21:56,240 --> 00:21:59,040
to some degree,
what are some of the things that we can be

412
00:21:59,040 --> 00:22:03,840
doing to sort of turn
back that biological clock?

413
00:22:03,920 --> 00:22:04,880
Yeah, So so

414
00:22:04,880 --> 00:22:09,000
first, let's start with diet and
and eating in general.

415
00:22:09,000 --> 00:22:13,200
So meal timing is is being understood

416
00:22:13,200 --> 00:22:18,000
as a very significant impact
on your health

417
00:22:18,080 --> 00:22:20,400
almost as much as the foods themselves.

418
00:22:20,400 --> 00:22:23,680
Not quite as much, but almost as much so.

419
00:22:23,760 --> 00:22:25,760
So when I say meal timing,

420
00:22:25,760 --> 00:22:28,360
you may have heard of something
called intermittent fasting.

421
00:22:28,360 --> 00:22:30,200
Technically, it's time restricted feeding.

422
00:22:30,200 --> 00:22:33,480
If you want to be accurate about the
the term for it.

423
00:22:33,480 --> 00:22:36,560
So time
restricted feeding is eating only within

424
00:22:36,560 --> 00:22:40,000
a certain time slot each day.

425
00:22:40,080 --> 00:22:44,920
And so what you'll oftentimes hear
is a ratio like for example, 16 eight.

426
00:22:45,000 --> 00:22:45,880
That's what I follow.

427
00:22:45,880 --> 00:22:49,240
So 16 hours of fasting, 8 hours of eating.

428
00:22:49,320 --> 00:22:52,640
So that would mean, for example,
eating only between 11 a.m.

429
00:22:52,640 --> 00:22:54,200
and 7 p.m.

430
00:22:54,200 --> 00:22:57,120
This is something that's very doable
for most people.

431
00:22:57,120 --> 00:22:59,880
You don't eat the first thing
when you wake up, or

432
00:22:59,880 --> 00:23:02,880
if you do, then you finish your last bite

433
00:23:02,880 --> 00:23:06,480
earlier in the evening
and you go longer without food.

434
00:23:06,720 --> 00:23:09,120
So trying to compress that window

435
00:23:09,120 --> 00:23:14,640
to approximately 16 eight would be
would be a really healthy move.

436
00:23:14,720 --> 00:23:17,640
Fasting
is another another thing to consider.

437
00:23:17,640 --> 00:23:23,240
Now, I would only suggest fasting
to people who are in proper condition

438
00:23:23,240 --> 00:23:27,520
to fasts like so, for example,
if you're if you're a female

439
00:23:27,720 --> 00:23:32,040
who has very low body fat percentage,
I would consider not fasting

440
00:23:32,040 --> 00:23:36,760
because it's probably going
to just regulate your hormones.

441
00:23:36,840 --> 00:23:37,960
It go ahead.

442
00:23:37,960 --> 00:23:40,160
You know, I'm glad you bring this up
because,

443
00:23:40,160 --> 00:23:43,160
you know, I think that a vast
majority of my listeners are women.

444
00:23:43,200 --> 00:23:46,320
We've talked about intermittent fasting,
but I have heard that

445
00:23:46,560 --> 00:23:50,120
for men, intermittent
fasting is a wonderful, wonderful thing.

446
00:23:50,120 --> 00:23:53,440
I've heard that it's
actually not so great for women.

447
00:23:53,520 --> 00:23:56,400
Have you heard differently
or do you have thoughts on that?

448
00:23:56,400 --> 00:23:58,440
Yeah, so so I have heard it.

449
00:23:58,440 --> 00:24:02,760
I haven't seen any specific scientific
studies on it, but just anecdotally,

450
00:24:02,760 --> 00:24:06,960
I have heard it a lot of times
from friends and on the Internet.

451
00:24:07,040 --> 00:24:11,120
What it seems to be is that women
have have different hormonal cycles,

452
00:24:11,120 --> 00:24:15,360
obviously, than men and different ratios
of hormones than men. And

453
00:24:15,440 --> 00:24:15,960
inches

454
00:24:15,960 --> 00:24:20,360
biologically, like evolutionarily,
like women are to be,

455
00:24:20,360 --> 00:24:23,640
you know, carriers of children, of babies
to be pregnant.

456
00:24:23,640 --> 00:24:23,880
Right.

457
00:24:23,880 --> 00:24:26,840
And so men don't have those requirements.

458
00:24:26,840 --> 00:24:31,680
And and so so it seems that by having

459
00:24:31,760 --> 00:24:35,160
by by fasting excessively too much.

460
00:24:35,240 --> 00:24:36,720
What is that actually doing?

461
00:24:36,720 --> 00:24:40,720
It's sending a signal to the body
that food is scarce.

462
00:24:40,800 --> 00:24:43,640
And if you think in the evolutionary
context

463
00:24:43,640 --> 00:24:49,520
and biology, if food is scarce,
nature doesn't want you to procreate

464
00:24:49,520 --> 00:24:52,640
because you then might die yourself or

465
00:24:52,640 --> 00:24:55,640
the child a newborn might die.

466
00:24:55,680 --> 00:24:59,880
Nature wants to incentivize you
to only procreate once there's food

467
00:24:59,880 --> 00:25:04,120
in abundance, adequate food to be able
to support yourself and the newborns.

468
00:25:04,200 --> 00:25:08,200
So that's my, my,

469
00:25:08,240 --> 00:25:12,160
my expectation, my feeling as to
why women might be more sensitive

470
00:25:12,280 --> 00:25:16,120
to it than than men, because they would
have to carry that child

471
00:25:16,200 --> 00:25:19,800
and they would need adequate
food to carry that child

472
00:25:19,880 --> 00:25:21,120
for for males, they don't

473
00:25:21,120 --> 00:25:24,520
seem to be as sensitive to it, though
I can say me personally,

474
00:25:24,520 --> 00:25:30,200
if I fast too much or I'm too hypo
caloric, so not enough calories each day.

475
00:25:30,280 --> 00:25:34,720
I definitely feel the difference
in terms of the quality of my sleep.

476
00:25:34,800 --> 00:25:38,840
I'd say my mood changes
so I'm not as happy.

477
00:25:38,920 --> 00:25:41,600
I am more like focused,

478
00:25:41,600 --> 00:25:44,200
but not as like positive and so on.

479
00:25:44,200 --> 00:25:47,560
So I can notice
these subtle changes in myself.

480
00:25:47,640 --> 00:25:50,840
And so I need to make sure
I balance the health versus like

481
00:25:50,840 --> 00:25:54,880
quality of life and,
and those around me to make sure better.

482
00:25:54,960 --> 00:25:58,040
Yeah, but, but certainly, yes,
there are a lot

483
00:25:58,160 --> 00:25:59,520
there's a lot of research out there.

484
00:25:59,520 --> 00:26:02,760
I would just caution, you know, especially
the women look into intermittent

485
00:26:02,760 --> 00:26:08,120
fasting always talk to your doctor
because I've heard both things right.

486
00:26:08,120 --> 00:26:15,760
So I know that it it
I know that in the, you know, sort of this

487
00:26:15,840 --> 00:26:18,240
biohacking community,

488
00:26:18,240 --> 00:26:22,920
that intermittent fasting is is
definitely something that people employ.

489
00:26:23,000 --> 00:26:26,000
We've had great podcasts on intermittent
fasting here on this show,

490
00:26:26,240 --> 00:26:29,040
but I have also heard from some doctors

491
00:26:29,040 --> 00:26:32,360
who've said,
I don't know if it's great for women.

492
00:26:32,440 --> 00:26:33,480
Yeah, yeah.

493
00:26:33,480 --> 00:26:37,480
So, so technically intermittent fasting
would be time restricted feeding,

494
00:26:37,480 --> 00:26:42,400
but it would require that you're eating
fewer calories than you typically would.

495
00:26:42,480 --> 00:26:46,800
And so if if you are intermittent fasting
by the strict definition of the term,

496
00:26:46,800 --> 00:26:50,600
which means you're eating fewer calories,
I can see that as being a concern for

497
00:26:50,600 --> 00:26:54,560
for your female audience, particularly
if they're not already overweight,

498
00:26:54,800 --> 00:26:57,800
they're overweight,
they have excess calorie storage.

499
00:26:57,840 --> 00:26:58,120
Right.

500
00:26:58,120 --> 00:27:01,960
And they can probably get away with it
more so than thinner.

501
00:27:01,960 --> 00:27:03,640
Women can.

502
00:27:03,720 --> 00:27:05,560
But if you're doing time restricted
feeding

503
00:27:05,560 --> 00:27:08,560
where you're not reducing
the calorie intake,

504
00:27:08,560 --> 00:27:12,200
you're just reducing the eating window
that I don't think

505
00:27:12,280 --> 00:27:15,720
women will be as sensitive to,
hormonally speaking,

506
00:27:15,800 --> 00:27:19,480
because if you eat the same number
of calories that you would otherwise eat,

507
00:27:19,720 --> 00:27:23,720
you're just eating them between 11
and seven instead of from 9 to 7.

508
00:27:23,720 --> 00:27:26,480
Let's say that shouldn't really have
that much of an impact.

509
00:27:26,480 --> 00:27:30,760
But if you're reducing your calorie
intake, which naturally oftentimes happens

510
00:27:30,760 --> 00:27:35,320
when you're eating in a smaller window
because you get fuller quicker,

511
00:27:35,400 --> 00:27:37,440
then that's
where there could be some trouble.

512
00:27:37,440 --> 00:27:42,000
So the calories, I think, are the critical
the critical issue for that.

513
00:27:42,080 --> 00:27:43,760
Thank you for clarifying that.

514
00:27:43,760 --> 00:27:44,920
I really appreciate that,

515
00:27:44,920 --> 00:27:47,480
because that makes much more sense
with the time restricted.

516
00:27:47,480 --> 00:27:50,160
You know, when you said that my mind
went to intermittent fasting,

517
00:27:50,160 --> 00:27:51,480
but it's not the same thing.

518
00:27:51,480 --> 00:27:56,760
And boy, you know, 11 to 7 does
seem very doable in the outside windows.

519
00:27:56,760 --> 00:27:58,760
Can you still be drinking water?

520
00:27:58,760 --> 00:28:00,120
Yes, Yes, of course.

521
00:28:00,120 --> 00:28:03,360
So just no, no food,
but you can be drinking water throughout.

522
00:28:03,600 --> 00:28:04,200
You can have. Water.

523
00:28:04,200 --> 00:28:07,120
You can even have black coffee. Right.

524
00:28:07,120 --> 00:28:08,720
So not with the milk.

525
00:28:08,720 --> 00:28:11,200
Latte and not now by morning, all.

526
00:28:11,200 --> 00:28:13,200
Day, but black coffee, you could throw it.

527
00:28:13,200 --> 00:28:15,680
You can probably even throw some stevia
in there. Right.

528
00:28:15,680 --> 00:28:18,520
So it's zero
calorie doesn't raise your blood glucose.

529
00:28:18,520 --> 00:28:19,720
So we want that a little bit sweet.

530
00:28:19,720 --> 00:28:23,200
But yeah,
none of the creamers or milks in there.

531
00:28:23,280 --> 00:28:23,560
Okay.

532
00:28:23,560 --> 00:28:26,560
So in addition to diet,

533
00:28:26,600 --> 00:28:29,560
what are some other behavioral changes
that we could be making

534
00:28:29,560 --> 00:28:33,280
to sort of help
turn back that biological clock?

535
00:28:33,360 --> 00:28:37,240
So so within the topic of diet is
the food itself that you're eating, right?

536
00:28:37,240 --> 00:28:40,680
So I'll just say the obvious stuff
is like minimize processed foods,

537
00:28:40,680 --> 00:28:44,800
eat as as much stuff
straight from the earth as you can.

538
00:28:44,880 --> 00:28:50,640
Don't go excessive
with with meats, especially red meats

539
00:28:50,720 --> 00:28:53,800
in fact, the best diet you can follow
are the two best diets.

540
00:28:53,800 --> 00:28:57,960
I should say that the most commonly known
one is the Mediterranean diet,

541
00:28:57,960 --> 00:29:02,920
which is, you know, the eating style
of Mediterranean named regions.

542
00:29:03,000 --> 00:29:05,640
But then we have our website, the NOVOS

543
00:29:05,640 --> 00:29:09,240
Longevity Diet, which takes
the Mediterranean diet as its foundation

544
00:29:09,480 --> 00:29:12,960
and then make some tweaks to it
based on the latest research

545
00:29:13,040 --> 00:29:16,040
to to improve it even further.

546
00:29:16,080 --> 00:29:19,440
So we would suggest people
take a look at the Noble's longevity diet.

547
00:29:19,680 --> 00:29:22,120
But the Mediterranean diet
is something that that is

548
00:29:22,120 --> 00:29:24,960
I think most people would enjoy
eating in the first place.

549
00:29:24,960 --> 00:29:25,280
Right.

550
00:29:25,280 --> 00:29:28,840
It's it's a very satisfying diet

551
00:29:28,920 --> 00:29:33,880
and it's not so restricted like something
like a ketogenic diet might be.

552
00:29:33,960 --> 00:29:37,120
So then beyond diet, obviously exercise.

553
00:29:37,120 --> 00:29:39,880
Now the question is
how much are you going to exercise?

554
00:29:39,880 --> 00:29:42,880
And what is the ideal versus
like the minimum effective dose.

555
00:29:43,080 --> 00:29:46,960
So the ideal would be that your weight
lifting, let's just say three days

556
00:29:46,960 --> 00:29:51,760
per week, you are doing
some form of cardio, ideally every day.

557
00:29:51,760 --> 00:29:54,920
Now that cardio doesn't
have to be high intensity

558
00:29:54,920 --> 00:29:57,920
or high heart rate zone cardio every day.

559
00:29:57,960 --> 00:30:02,880
So in other words, zone to cardio,
which is when your heart rate is,

560
00:30:02,960 --> 00:30:08,200
I believe, around 70% of your max
heart rate in that in that neighborhood.

561
00:30:08,280 --> 00:30:12,480
If you're doing that for,
you know, 25 minutes

562
00:30:12,480 --> 00:30:16,360
a day is the approximate minimum
that you want to do.

563
00:30:16,440 --> 00:30:18,480
But if you can do
even more than that, great.

564
00:30:18,480 --> 00:30:21,040
It's not really putting
that much stress on your body,

565
00:30:21,040 --> 00:30:23,520
but it is very healthy
to be in that zone, too.

566
00:30:23,520 --> 00:30:27,120
So doing as much as that, as much of that
as you are willing to do.

567
00:30:27,120 --> 00:30:31,440
But at least about 25 minutes
per day is going to.

568
00:30:31,440 --> 00:30:33,640
It's like Perritos principle,
that 80/20 rule.

569
00:30:33,640 --> 00:30:37,320
You're going to put in 20% of the effort
and get 80% of the benefits

570
00:30:37,520 --> 00:30:41,040
when it comes to longevity
and slowing down aging, you'll largely

571
00:30:41,040 --> 00:30:45,320
get that from doing this
zone to cardio every day.

572
00:30:45,320 --> 00:30:46,640
Plus the weight lifting.

573
00:30:46,640 --> 00:30:47,240
Is, don't you?

574
00:30:47,240 --> 00:30:49,120
Are we talking about like a brisk walk?

575
00:30:49,120 --> 00:30:52,240
Is that a jog? You know, for most of us.

576
00:30:52,320 --> 00:30:53,600
It's going to depend on your

577
00:30:53,600 --> 00:30:58,320
fitness levels for for some
who are not particularly fit.

578
00:30:58,320 --> 00:31:00,640
That's just going to be a brisk
walk. Right.

579
00:31:00,640 --> 00:31:04,720
So a way to think about
it is you're you're breathing heavily,

580
00:31:04,720 --> 00:31:07,680
but you can still breathe
with your mouth closed

581
00:31:07,680 --> 00:31:11,160
and you can have a conversation
with somebody like you can say

582
00:31:11,160 --> 00:31:13,200
a full sentence without being winded.

583
00:31:13,200 --> 00:31:14,880
But when you finish the sentence,
you're going

584
00:31:14,880 --> 00:31:16,520
to need to take a gasp of air, Right?

585
00:31:16,520 --> 00:31:19,520
So you're like in that range.

586
00:31:19,600 --> 00:31:22,160
And so obviously,
if you have something like an Apple

587
00:31:22,160 --> 00:31:26,640
Watch or a heart rate monitor, you can
actually track and see which there you go.

588
00:31:26,800 --> 00:31:30,480
So you can easily
see what heart rate zone you are in

589
00:31:30,640 --> 00:31:34,560
when you use the fitness setting on the
the Apple Watch.

590
00:31:34,640 --> 00:31:38,920
But otherwise, that simple test of like,
can I can I say a sentence and can I

591
00:31:39,000 --> 00:31:44,160
can I do this with my nose closed
but still feeling the pressure of

592
00:31:44,280 --> 00:31:48,040
faster breathing
that's probably getting to that zone too.

593
00:31:48,120 --> 00:31:48,520
Amazing.

594
00:31:48,520 --> 00:31:51,560
So we're looking at what,
like 100 and 2040 minutes a week.

595
00:31:51,640 --> 00:31:55,080
You said about 20 minutes a day.

596
00:31:55,160 --> 00:31:56,560
I believe the exact number

597
00:31:56,560 --> 00:32:00,280
I calculated was like 23 minutes,
but I just round up to 25 minutes a day.

598
00:32:00,320 --> 00:32:03,320
25 minutes a day, seven days a week.

599
00:32:03,360 --> 00:32:04,080
Yeah.

600
00:32:04,080 --> 00:32:06,920
I mean, if you take a day off here
and there, that's that's fine.

601
00:32:06,920 --> 00:32:10,360
Like I personally work out
six out of seven days per week

602
00:32:10,360 --> 00:32:13,000
and then one day on Sunday,
it's my day of rest.

603
00:32:13,000 --> 00:32:14,560
But I will still

604
00:32:14,560 --> 00:32:17,600
I'll still walk a good amount
or I'll do like a leisurely bike ride.

605
00:32:17,600 --> 00:32:20,600
So I might not be in zone two,
but I'm physically active.

606
00:32:20,600 --> 00:32:21,360
I'm still moving.

607
00:32:21,360 --> 00:32:23,040
I'm laying on the couch all day long.

608
00:32:23,040 --> 00:32:25,920
So you don't have to be like perfect
about it.

609
00:32:25,920 --> 00:32:27,960
But yeah, most days,

610
00:32:27,960 --> 00:32:31,360
five or six days a week,
if you're doing that, that's that's great.

611
00:32:31,440 --> 00:32:36,120
And that's like the minimum effective dose
for like slowing down the aging.

612
00:32:36,120 --> 00:32:37,480
I think everyone can do it.

613
00:32:37,480 --> 00:32:40,880
They just need to have the form,
the habit to, to do it.

614
00:32:40,880 --> 00:32:45,200
Like I for example, every morning
I will do a light jog to be in zone

615
00:32:45,200 --> 00:32:49,240
two cardio
and I'll listen to a podcast, for example.

616
00:32:49,240 --> 00:32:49,560
Right.

617
00:32:49,560 --> 00:32:53,640
So that's like instead of sitting at home
listening to a podcast like I do it by,

618
00:32:53,640 --> 00:32:54,760
you know, doing a light jog.

619
00:32:54,760 --> 00:32:59,840
So try to create like a ritual out of it,
something that you enjoy doing while

620
00:32:59,840 --> 00:33:04,320
doing that jog, which will then increase
the likelihood that you'll adhere to it.

621
00:33:04,400 --> 00:33:05,160
Okay.

622
00:33:05,160 --> 00:33:08,880
So I want to make sure that we have time
for some of these supplements because,

623
00:33:08,880 --> 00:33:12,440
you know, that's a lot of what I think
people are looking towards these days

624
00:33:12,440 --> 00:33:15,680
is, you know, in addition
to having a good diet, in addition

625
00:33:15,680 --> 00:33:22,240
to having, you know, getting proper
amount of exercise, getting enough sleep,

626
00:33:22,320 --> 00:33:24,840
what are some of the new technologies
that are out there?

627
00:33:24,840 --> 00:33:28,520
You know,
and I know Noble's has two products here.

628
00:33:28,600 --> 00:33:30,520
You've got Core and NOVOS boost.

629
00:33:30,520 --> 00:33:31,960
I want to make sure
we get to talk about this.

630
00:33:31,960 --> 00:33:36,760
So, so so tell us a little bit about this
supplementation, why we need it.

631
00:33:36,760 --> 00:33:39,120
What are the things
that we should be taking?

632
00:33:39,120 --> 00:33:39,960
Sure.

633
00:33:39,960 --> 00:33:44,040
So so let me set the context first
so people get confused about supplements

634
00:33:44,040 --> 00:33:44,680
and sometimes

635
00:33:44,680 --> 00:33:47,800
they think NOVOS is a multivitamin
and they say, what's the difference

636
00:33:47,800 --> 00:33:49,040
between a multivitamin in this?

637
00:33:49,040 --> 00:33:52,640
So the context is we think of supplements

638
00:33:52,640 --> 00:33:55,840
in the form of general health supplements.

639
00:33:55,840 --> 00:34:00,000
This is the stuff that you need
just to to be generally healthy.

640
00:34:00,000 --> 00:34:02,600
This is what the government has said
an RDA for.

641
00:34:02,600 --> 00:34:06,040
It's like vitamin C, vitamin E, vitamin A,

642
00:34:06,120 --> 00:34:09,040
magnesium, potassium,
the B, vitamins and so on.

643
00:34:09,040 --> 00:34:09,240
Right.

644
00:34:09,240 --> 00:34:11,600
And this you can get from a multivitamin,

645
00:34:11,600 --> 00:34:14,120
you can get it from
the foods that you eat.

646
00:34:14,120 --> 00:34:17,920
And we do suggest that everyone
look into supplementation because most

647
00:34:18,000 --> 00:34:20,720
almost definitely
you're not getting adequate nutrients

648
00:34:20,720 --> 00:34:24,240
just from your diet alone, no matter how
healthy you eat, myself included.

649
00:34:24,480 --> 00:34:26,280
I still need to supplement.

650
00:34:26,280 --> 00:34:28,040
That's general health supplements.

651
00:34:28,040 --> 00:34:31,600
Then you have

652
00:34:31,640 --> 00:34:33,800
targeted supplements for specific goals.

653
00:34:33,800 --> 00:34:38,400
So you have like maybe a pre-workout
supplement or a post-workout supplement.

654
00:34:38,600 --> 00:34:41,280
Maybe you have a

655
00:34:41,280 --> 00:34:44,040
a supplement
focused on reducing your anxiety

656
00:34:44,040 --> 00:34:47,320
or just keeping you calm or helping
you sleep at night.

657
00:34:47,400 --> 00:34:50,160
And then you have the category
of longevity supplements.

658
00:34:50,160 --> 00:34:52,160
And this is where Noble specializes.

659
00:34:52,160 --> 00:34:57,120
So we focus on creating formulations
that are going to slow down

660
00:34:57,120 --> 00:35:00,680
your biological pace of aging
and the way that we do it, the way

661
00:35:00,680 --> 00:35:04,760
we approach it is based on
what's known as the mechanisms of aging.

662
00:35:04,840 --> 00:35:09,920
Or put another way,
the 12 biological causes of aging.

663
00:35:10,000 --> 00:35:14,400
These are the causes that scientists over
more than a decade of work

664
00:35:14,600 --> 00:35:20,280
have put together as the reasons
from a microscopic level why we age.

665
00:35:20,520 --> 00:35:23,800
These are the things that start to go
wrong

666
00:35:23,880 --> 00:35:26,280
biologically as we age

667
00:35:26,280 --> 00:35:29,240
and we want to slow down

668
00:35:29,240 --> 00:35:35,000
their degradation as much as possible,
which if we can do that

669
00:35:35,080 --> 00:35:35,640
across

670
00:35:35,640 --> 00:35:38,640
all of these different hallmarks
simultaneously,

671
00:35:38,640 --> 00:35:42,440
we're going to stand the best chance
at slowing down the aging process

672
00:35:42,440 --> 00:35:46,160
because they're all interconnected,
they feed off of each other.

673
00:35:46,240 --> 00:35:50,040
And if you only slow down one of them,
you're not going to have

674
00:35:50,040 --> 00:35:53,800
that much of an impact compared to
if you slow down all of them.

675
00:35:54,000 --> 00:35:57,960
Think of the analogy of a car,
an old car with like tires

676
00:35:57,960 --> 00:36:02,560
that are flat and rust all over them
and the engine doesn't have oil in it.

677
00:36:02,600 --> 00:36:05,880
If you just fill the tires
up, you're not going to get very far.

678
00:36:05,960 --> 00:36:08,920
But if you clean up everything
similar tenuously,

679
00:36:08,920 --> 00:36:12,760
that's when you're really getting the car
in good condition to drive again.

680
00:36:12,840 --> 00:36:16,560
So we are the first company,
the only company to create

681
00:36:16,560 --> 00:36:20,560
a formula to address
all 12 of these hallmarks simultaneously

682
00:36:20,640 --> 00:36:23,560
across all industries,
including biotech and pharma.

683
00:36:23,560 --> 00:36:26,920
We're over the counter, of course, but
we're the first company to ever do this.

684
00:36:27,000 --> 00:36:30,800
We have a scientific advisory
board of scientists from Harvard and MIT

685
00:36:30,960 --> 00:36:34,840
and the Salk Institute that study aging
and helped us with this formulation.

686
00:36:35,080 --> 00:36:38,760
We filed four patents on this formulation
and we've done a number

687
00:36:38,760 --> 00:36:42,560
of different scientific tests
on the formulation and case studies.

688
00:36:42,560 --> 00:36:44,920
So, for example, a case study we did,

689
00:36:44,920 --> 00:36:47,920
we administered Noble Score and boost

690
00:36:48,080 --> 00:36:52,080
to the participants
and 73% of them slowed down

691
00:36:52,080 --> 00:36:56,520
their biological pace of aging
by a statistically significant margin.

692
00:36:56,600 --> 00:36:58,160
So it wasn't coincidental.

693
00:36:58,160 --> 00:37:02,040
In fact, the p value for the geeks
out there who want to know the probability

694
00:37:02,040 --> 00:37:08,120
that it was just a coincidence versus
it being the supplement itself was 0.001.

695
00:37:08,200 --> 00:37:11,200
Typically in science,
you need it to be 0.05.

696
00:37:11,400 --> 00:37:15,000
So this was 50 times
more reliable than the typical standard

697
00:37:15,000 --> 00:37:19,760
for scientists to conclude
that something was coming from from the

698
00:37:19,840 --> 00:37:23,440
from the intervention in this case
being de novo supplements.

699
00:37:23,520 --> 00:37:27,720
And 0% of people accelerated their aging,
which is also important to know

700
00:37:27,720 --> 00:37:30,360
because you have these stressors
in life, right.

701
00:37:30,360 --> 00:37:34,840
And different different things,
whether it be literally stress or excess

702
00:37:34,840 --> 00:37:38,480
drinking or not eating healthy or whatever
it might be,

703
00:37:38,560 --> 00:37:42,240
you would expect some people would have
accelerated, but nobody accelerated.

704
00:37:42,240 --> 00:37:43,680
Everyone that either stayed the same

705
00:37:43,680 --> 00:37:47,840
or the large majority
actually slowed down their pace of aging.

706
00:37:47,920 --> 00:37:49,000
So that was the case study.

707
00:37:49,000 --> 00:37:50,880
We have clinical trials underway.

708
00:37:50,880 --> 00:37:54,760
We've done in vitro studies
to to show that we reduce DNA damage

709
00:37:54,760 --> 00:37:56,640
from irradiation.

710
00:37:56,640 --> 00:37:59,400
We reduced cellular senescence.

711
00:37:59,400 --> 00:38:01,040
These are important for skin
health. Right?

712
00:38:01,040 --> 00:38:05,040
So DNA damage is what really starts
to break down the collagen

713
00:38:05,120 --> 00:38:08,520
and the matrices in our face.

714
00:38:08,520 --> 00:38:12,280
And then we start to wrinkle
and our skin starts to age

715
00:38:12,360 --> 00:38:16,760
and we reduce
DNA damage in an in vitro study

716
00:38:16,840 --> 00:38:19,200
by administering a noble score.

717
00:38:19,200 --> 00:38:22,880
And we also reduce senescent
cells, footprints.

718
00:38:22,880 --> 00:38:26,640
So senescent cells are these zombie cells
that start to accumulate

719
00:38:26,640 --> 00:38:27,720
as you get older.

720
00:38:27,720 --> 00:38:30,840
Typically it's that the
the cell is damaged.

721
00:38:30,840 --> 00:38:32,680
It's it's not functioning properly.

722
00:38:32,680 --> 00:38:33,880
There might be DNA damage.

723
00:38:33,880 --> 00:38:36,000
It might actually
even be a cancerous cell.

724
00:38:36,000 --> 00:38:39,480
And so the body will actually turn
that cell senescence.

725
00:38:39,560 --> 00:38:41,080
It kind of arrest that cell.

726
00:38:41,080 --> 00:38:45,080
But the problem is that cell secretes
inflammatory molecules

727
00:38:45,160 --> 00:38:48,760
that cause nearby cells to get damaged
and then become senescent, too.

728
00:38:48,840 --> 00:38:51,840
So as we age, that increases
exponentially.

729
00:38:51,920 --> 00:38:55,680
It's one of the top targets for skin care
companies, is to reduce

730
00:38:55,680 --> 00:38:59,560
senescence in skin because it leads
to the rigidity of the skin.

731
00:38:59,560 --> 00:39:02,040
And then again, wrinkles can form from it.

732
00:39:02,040 --> 00:39:06,000
So we found in a study done
at Newcastle University

733
00:39:06,240 --> 00:39:09,240
that we were able
to reduce the size of senescent cells

734
00:39:09,240 --> 00:39:12,240
by approximately 50% or so

735
00:39:12,360 --> 00:39:17,040
and and presumably
with also reduced the progression of cells

736
00:39:17,040 --> 00:39:20,040
because of the DNA protection
that I mentioned earlier.

737
00:39:20,040 --> 00:39:21,240
So we're just getting

738
00:39:21,240 --> 00:39:25,040
started with the studies, but so far
they're all very positive in our favor

739
00:39:25,040 --> 00:39:29,280
for Novos doing something significant
for the aging process.

740
00:39:29,360 --> 00:39:29,800
Amazing.

741
00:39:29,800 --> 00:39:36,320
And there is a lot of talk right
now about an end and end and

742
00:39:36,400 --> 00:39:37,680
I know that there's some talk

743
00:39:37,680 --> 00:39:42,040
that the FDA
is trying to turn this into a drug.

744
00:39:42,120 --> 00:39:44,960
Are you worried about that at all?

745
00:39:44,960 --> 00:39:47,960
So there's only so much I can say.

746
00:39:48,000 --> 00:39:51,880
It's technically there is a scientist,
a well-known scientist

747
00:39:51,880 --> 00:39:55,840
in the longevity field
who is a founder of a company

748
00:39:55,920 --> 00:40:00,960
that is trying to monopolize this
substance and make it prescription only.

749
00:40:01,040 --> 00:40:04,640
So this person has talked a lot about
and a man and brought the public's

750
00:40:04,640 --> 00:40:06,120
attention to it.

751
00:40:06,120 --> 00:40:09,960
And then multiple companies, not only us,
but others, have invested a lot of money

752
00:40:09,960 --> 00:40:13,600
into building out this this the product

753
00:40:13,680 --> 00:40:16,680
and marketing the product
and getting it into the hands of consumers

754
00:40:16,800 --> 00:40:20,760
only for this person and the company
they're affiliated with, technically,

755
00:40:21,000 --> 00:40:24,440
to try to work through the FDA,
through a loophole, to try to take it off

756
00:40:24,440 --> 00:40:24,840
the market.

757
00:40:24,840 --> 00:40:28,160
The FDA in closed door
discussions, has said that it's

758
00:40:28,160 --> 00:40:31,680
not a matter of safety,
it is simply a commercial topic.

759
00:40:31,680 --> 00:40:33,680
So, yeah, we will.

760
00:40:33,680 --> 00:40:37,680
We'll see where it goes,
but we're continuing to sell it for

761
00:40:37,680 --> 00:40:41,280
as long as we're able to, and hopefully
it doesn't turn into a legal matter.

762
00:40:41,280 --> 00:40:45,840
But if it is, we're ready
to protect our consumers to be able

763
00:40:45,840 --> 00:40:51,120
to purchase this natural substance,
which I should mention is in our bodies.

764
00:40:51,120 --> 00:40:51,400
Right?

765
00:40:51,400 --> 00:40:52,560
We produce and I mean,

766
00:40:52,560 --> 00:40:56,920
naturally, it's also in our food supply,
like tomatoes have any men in them.

767
00:40:57,000 --> 00:41:00,240
But the levels decline as we get older.

768
00:41:00,240 --> 00:41:04,200
And so we don't believe it's fair
for a biotech company

769
00:41:04,200 --> 00:41:06,280
to be able to monopolize it
and make it prescription

770
00:41:06,280 --> 00:41:10,160
only when it is something found in nature
and in our bodies.

771
00:41:10,240 --> 00:41:13,240
No. And, you know,
I wish we had more time to get into this.

772
00:41:13,440 --> 00:41:16,200
Can you quickly over

773
00:41:16,200 --> 00:41:19,720
and and and some of the benefits
I know that were kind of

774
00:41:19,720 --> 00:41:21,760
I want to be mindful of your time.

775
00:41:21,760 --> 00:41:23,160
Sure. Yeah. Sure.

776
00:41:23,160 --> 00:41:26,280
So so MMN is a precursor

777
00:41:26,400 --> 00:41:30,360
for another molecule in our bodies
called NAD Plus.

778
00:41:30,480 --> 00:41:36,440
And NAD is is a molecule that's
responsible for many different processes.

779
00:41:36,440 --> 00:41:41,560
So being a precursor
and fuels the creation of the energy.

780
00:41:41,640 --> 00:41:45,080
And the energy is involved
in many different processes,

781
00:41:45,080 --> 00:41:48,840
including the production of sirtuins
and sirtuins

782
00:41:48,840 --> 00:41:51,880
can repair DNA, right?

783
00:41:51,880 --> 00:41:56,600
So when you're out in the sun
and the UV rays are damaging your DNA

784
00:41:56,600 --> 00:42:01,040
and causing mutations,
we actually have mechanisms in our body

785
00:42:01,040 --> 00:42:05,400
to be able to go and repair
that DNA rescue, that DNA to prevent it

786
00:42:05,400 --> 00:42:10,800
from turning into, in the worst case,
into like a carcinoma, right into a

787
00:42:10,880 --> 00:42:13,000
into a melanoma.

788
00:42:13,080 --> 00:42:16,400
So NAD

789
00:42:16,480 --> 00:42:20,960
is is the fuel essentially
for those sirtuins.

790
00:42:20,960 --> 00:42:24,920
So that's one thing it does, but
it is also involved in the Krebs cycle.

791
00:42:24,920 --> 00:42:26,880
So you might remember
from high school biology

792
00:42:26,880 --> 00:42:31,000
that the Krebs cycle is the process
through which our bodies produce energy.

793
00:42:31,000 --> 00:42:35,680
So you take those carbohydrates,
that protein to a lesser extent,

794
00:42:35,680 --> 00:42:40,280
but still you can get energy from certain
forms of protein and fat.

795
00:42:40,360 --> 00:42:43,360
And the Krebs cycle is what is then

796
00:42:43,360 --> 00:42:46,200
producing ATP,

797
00:42:46,200 --> 00:42:49,200
which is the energy currency
that our cells use,

798
00:42:49,200 --> 00:42:53,400
our brain uses, our heart uses to be able
to perform their functions.

799
00:42:53,480 --> 00:42:58,440
And so our need is
is a critical component of that.

800
00:42:58,440 --> 00:43:03,920
So other benefits can include
improvements in energy.

801
00:43:04,000 --> 00:43:06,960
There's there's research being done,

802
00:43:06,960 --> 00:43:10,960
finding reductions in or
I should say improvements in health span.

803
00:43:11,040 --> 00:43:15,880
So different
aspects of the aging process to be able to

804
00:43:15,960 --> 00:43:19,600
improve healthy living essentially over
the long term

805
00:43:19,680 --> 00:43:23,240
is some of the promise
that the animal and molecule holds.

806
00:43:23,320 --> 00:43:26,600
And I thought that there was a lot
of promising research in the field

807
00:43:26,600 --> 00:43:31,920
of Alzheimer's, and that's sort of where
this this drug battle is kind of coming.

808
00:43:31,920 --> 00:43:36,280
And so listen, for my listeners out there,
I maybe can't say this

809
00:43:36,360 --> 00:43:40,520
I'm not a doctor by any means,
but I've done some research.

810
00:43:40,520 --> 00:43:43,880
This seems like a very, very promising

811
00:43:43,960 --> 00:43:46,680
I don't know what you call it,
a supplement.

812
00:43:46,680 --> 00:43:48,480
Yeah, I mean, it is a supplement.

813
00:43:48,480 --> 00:43:50,400
But it it's a promising one.

814
00:43:50,400 --> 00:43:52,800
I would say. Get it while you can

815
00:43:52,800 --> 00:43:55,800
and Noble Score certainly has.

816
00:43:55,800 --> 00:43:57,120
So I write the novels.

817
00:43:57,120 --> 00:44:00,120
Bruce has a very high quality,
reputable one.

818
00:44:00,240 --> 00:44:03,440
You can read all about it on their blog
and on their website.

819
00:44:03,440 --> 00:44:05,560
You know, Chris,
I want to thank you so much.

820
00:44:05,560 --> 00:44:09,240
I feel like I could talk to you
for hours and hours and hours about this.

821
00:44:09,320 --> 00:44:12,600
I think that we are at the start of like,
you know, longevity

822
00:44:12,600 --> 00:44:16,920
is going to become very mainstream
in the very near future.

823
00:44:17,000 --> 00:44:20,880
If people want to know more about
Novos, where can they go.

824
00:44:20,960 --> 00:44:23,080
So they can go to Novo slabs dot com.

825
00:44:23,080 --> 00:44:26,080
We're also on all of the social networks
as Novos Labs.

826
00:44:26,320 --> 00:44:29,520
And then me personally,
I also have a blog Slow My Age

827
00:44:29,520 --> 00:44:33,280
where I post my my results in my lifestyle
hacks and so on.

828
00:44:33,280 --> 00:44:37,880
That's a little bit more geeky,
not as mainstream as as the Novos website.

829
00:44:37,960 --> 00:44:41,760
And I'm on Instagram and Twitter
as @slowmyage as well.

830
00:44:41,840 --> 00:44:44,880
I want to thank you so much
for being with us today.

831
00:44:44,880 --> 00:44:47,240
This is so awesome.
I mean, I'm just fascinated.

832
00:44:47,240 --> 00:44:49,080
I got to check out your blog.

833
00:44:49,080 --> 00:44:52,080
You know, definitely check this out.

834
00:44:52,200 --> 00:44:55,320
If you have questions you want me to pass
on to Chris, I'm always happy to do so.

835
00:44:55,560 --> 00:44:58,360
You can email me
at hello@artbeautypodcast.com.

836
00:44:58,360 --> 00:45:02,440
You can find us on Facebook, Instagram
and YouTube @artbeautypodcast.

837
00:45:02,440 --> 00:45:05,160
And as always,
we will see you next Tuesday.

838
00:45:05,160 --> 00:45:14,200
Bye! .
