This is the Art Beauty podcast, where we are always reaching for truth
and beauty. Remember the brands on the show?
We're not paying to be here, so we get to asking the questions
that you want answered because you deserve to be informed
so you can make the best choices for yourself.
With that said, I'm in today.
My fabulous co-host is Chris Mirabile.
He is the founder of NOVOS He is a biohacker,
has an incredible story, an entrepreneur, a brain tumor survivor.
So we are going to hear all about his journey.
And then also he's going to tell us a little bit about
aging and this concept of aging
and biohacking, which I know that you are as interested in as I am.
So with that said, we've got a lot to cover today.
Let's get right into it.
Chris, welcome to the show.
Thank you, Amber. It's a pleasure to be here.
So, you know, I have to say,
before we even get started, you have such an incredible background.
Could you maybe tell a little bit about why
you were so interested in health in the first place?
Sure.
Well, it actually all began when I was 12 years old.
I saw an issue of Men's Health magazine at the bookstore.
And I decided at that moment that I needed to focus on my health.
I wanted to be attractive to the girls in school.
So I started exercising and eating a healthy diet at 12 years out.
Okay.
And I did it every single day.
I'd come home from school and I would do pull ups on the pullup bar
that my my father installed in our basement and
and it was it was all the more shock to me that when I was 16 years old,
I suddenly had a seizure while out in on a school trip in New York City. And
it turned out that it was caused by a brain tumor.
And so that was the moment where my thinking completely shifted.
And by my perception of health evolved from one
that was the superficial side of health, of trying to be attractive and
play sports.
Well, to excuse me to one in which I understood that health was
was more complex than that was biology and avoidance of disease.
And so that's when I decided that it would be important for me to
try to focus on never laying in a hospital bed again, contemplating mortality,
at least until my final days, hopefully a very long time from then.
And that that started my journey and planted the seed
for what is now essentially what I've created with no boss.
I mean, so at 16 years old, to have such,
you know, a brush with mortality, it certainly is life changing.
You know, for anybody who's out there before we kind of move on.
Do you have advice for something that kind of got you through that time?
Oh, you know, it's it's
for me, I chose I made a conscious decision
to look at the experience as a gift, as
a gift from which I can learn,
see aspects of life that others don't have the ability to see
or at least won't see until much later in their lives.
So I tried to find all of the positives that I could and reframe the experience
rather than from a victim mindset of like, why me?
And the ways in which it may have hurt me instead into an empowered mindset of
what can I take out of this experience and what can I what can they do with that?
How can I lead live a better life as a result of this?
Now, was that recovery? And I'm only asking.
I had a good friend who also at a very young age
had a brain tumor and and it was a really tough recovery.
I mean, he lost a lot of his speech
walking ability, which now has come back.
But to be honest, not 100%.
What was that like for you?
For me, fortunately, I didn't really have that many long term side effects.
I'd say the number one was
my memory.
It was shot.
I remember the first year this was going
into Saturdays for college and
and I had I had a tutor who asked me to repeat a sentence
that she had just read to me, and I couldn't repeat the sentence.
It was literally 2 seconds later and I could not repeat the sentence.
That's how bad my memory was.
And I had gone from doing very well in school and being in advanced classes
to now being, you know, at literally at the bottom of the rung,
like struggling to even just remember a sentence.
So it was really humbling.
And it taught me
excuse me, it really taught me,
show me another side of life, of of, you know, disability and not being capable
and really just opened my mind up
in so many different ways, made me more empathetic.
And and that lasted for a while.
Memory, you know, for for years probably.
But the first year in particular, especially
with all of the anti-seizure medication that I was prescribed
by that first year, it really slow me down a lot.
I mean, I got to be honest,
talking to you now and seeing you've had some tremendous successes.
You know, you've also had some tremendous losses.
I want to be mindful of the time here, but I will say that you check out some of
your other podcasts that you've been on because you really have incredibly
just an incredible entrepreneurial journey to get to where you are now.
Super inspiring.
But, you know,
you wouldn't be able to tell that you had all of this hardship early on.
So, you know, in terms of this idea and sort of jumping forward,
when you became interested in sort of what can I do today
to sort of take control of my health?
You know, we've heard a lot about this difference
between a biological age and chronological age,
and that we can actually sort of have a biological agent younger
than our chronological age for people who might not have be familiar with that.
Can you explain what that is, what our biological age is, what our chronic
or chronic chronological age is, and how we can sort of tell the difference?
Yeah.
So chronological age is what we're all familiar with when we say,
How old are you? Right.
That's how many birthdays you've had.
Biological age is something
related to how old our biological systems are,
our cellular integrity, their capacities and capabilities,
and essentially that then leads to things like your disease
risk, your more mortality risk and your ability to perform functions.
Now I'll drive it home for people.
I think that people can really relate to this concept, this idea of
everyone knows that 50 year old who looks like they're 65 or 70
and everyone knows that 50 year olds who looks like they're 40
or even maybe in their late thirties.
And you question like, how is it possible that that person is looking so young?
And when you put those two people next to each other, the older
looking and younger looking person, that's really a good picture of someone
that most likely had an accelerated biological pace of aging
and someone who had a decelerated biological pace of aging.
What most people don't realize is
I think people just assume this is genetics.
Like that person got lucky or they have really good genes.
The fact is that researchers have found that 90% of
your pace of aging is actually based on your lifestyle and environment.
It is not based on your genetics.
It's only 10% of the equation.
It's a little bit more
maybe for like super centenarians, people who live to 120 years old.
But for for the vast majority of us,
it's actually only 10% or less that is coming from genetics.
So I think that that's important.
It's empowering for people to realize you actually can do something about this.
So those of us who are proactive, people who like to
to take charge in our lives and create the lives that we want for ourselves,
that's really important information because now you can actually do
something about it and slow down the pace of aging.
So for people who are out there
wondering, like, well, wait a minute, I feel super young,
how can I actually tell what my biological age is?
What are our options out there?
It's a great question.
So there's multiple different ways to do it.
Scientists, this is cutting edge science right now.
This is literally like I went to a science event
just a month ago, and researchers are presenting their newest
biological age clocks straight out of the university. So
typically
they're measuring what's known as your epigenome.
Now, it's not always measuring the epigenome,
but those are the most promising, the most researched
biological age clocks in existence right now.
And your epigenome is the layer that sits right next to your genome
or your genetics. Right.
So everyone's familiar with genes at this point.
But what most people aren't familiar with is that you have an epigenome, which is
which genes are turned on and off.
So if your genes are the piano keys, the epigenome is the piano player
determining which genes or keys to play, right.
And so as you age, maybe when you're young,
that the tune that's being played is, you know, Tchaikovsky, right?
It's a symphony.
And then as you age, certain keys are incorrectly pressed
or they're missing the beat, missing the rhythm.
Right.
So you're pressing the wrong keys or you're missing keys and it no longer
sounds like that perfect symphony when you were younger.
And there are patterns to this specific genes in particular
that these algorithms that the scientists are creating
can identify and based on your biological age.
So essentially, again, your risk of of a disease and or mortality.
They're able to create these algorithms that will then tell you your equivalency.
So if you are, for example,
I can talk about myself actually with this.
So so I'm. Trying to brag.
Time to brag, but I'll tell you why I'm saying brag and admit it.
But yes. Okay.
So a humblebrag.
So yeah, I'm 39 years old biologically, I started chronologically,
but biologically I'm more than 13 years
younger than that, according to not just one biological age clock,
but I've done about a dozen of them and I've taken the average of those.
So that's basically and there's there's a reason for that
because some clocks are more accurate than others.
And we can talk about that if you care to.
But there's like third generation clocks that are the most accurate
and then they're first generation clocks that people are companies are also selling
that are not particularly accurate,
but sorry, go ahead.
Yeah.
So okay, so for everybody
who's listening out there, I mean, look, I have to be I'm turning 44 next week.
I feel pretty good. I feel young.
I took one of these tests and I was convinced
there's no way that I'm aging
at a rate equivalent to my chronological age.
But it was it was exactly one I was aging.
My pace of aging was one, which means I am chronologically
for it, while at the time it took it 43 and biologically 43.
I was really bummed out about that.
I got to be honest.
And now in terms of the tests, I took, one that was a saliva based test.
I know that Novos has one and I was looking into this today.
That's a blood, you know, you do a little drop of blood and you send that in.
Do you think that there's a difference in in the accuracy there?
Yes, there definitely is.
So blood based tests, as you might
suspect, are more accurate than saliva based tests.
And so the blood based tests that we offer it,
you just prick your finger and then you spread it on an index card
within a little circle, and then you ship that back to us.
We offer three different tests in our kit.
So it's called Noble's age.
And within our kit we've got the do you need and pace clock,
which is the most advanced biological age clock out there right now.
It was created by researchers at Columbia and Duke University's.
We licensed it from them.
And this is telling you your rate of aging right now.
So a one, as you mentioned before, would mean every one
chronological year you're aging one biological year.
Ideally, you get that to be less than one.
Mine, for example, is 0.69.
So that implies I'm aging 31% slower
than the average person is per year.
And we can talk about how how I believe I achieve that if you'd like to later on.
But that's the first test.
And we think that this is the most important one
because this is telling you your trajectory right now
based on your lifestyle, are you accelerating your aging
like maybe aging 1.2, so 20% faster than average?
Or are you aging slower than average?
And this is also one of the most sensitive tests to change.
So in as little as 3 to 6 months, based on your lifestyle changes,
you can then see those those scores changing.
The second test we offer is biological age
that is less sensitive to change.
There are other companies out there as well.
So in biological age clocks, they're not as accurate and as precise
as that pace of aging is quite yet.
So we we tell our customers to take it with a grain of salt.
If you're looking at the kid overall, we say put 85% of
of your focus on that you need and pace clock
and maybe you know 5 to 10% in the biological age and that's going to
include related aging throughout your life lifetime like maybe you had
a traumatic
childhood for example has has been found to accelerate aging
and that could be found even in the later decades of your life.
And then the third test that we offer is telomere length.
This is included in that Noble's age kid, and telomeres
are the end caps of your chromosomes.
They protect your DNA, and those get shorter every time your cells divide.
But they can also be lengthened by different foods and healthy habits
and so on.
And so for this test, it's not a direct marker of your biological age,
but what you want to make sure of is that your telomeres don't get too short.
If they get too short, then you have a higher risk of different
diseases of aging like forms, certain forms of cancer and so on.
So it's more of a check off the box.
They're not too short. Okay, I can rest easy at night.
So those are the three tests that we offer in our age. Kit.
You know, I want to go back to something you said before because, you know,
I keep it real with everybody here.
I'm super fascinated in this.
But I think, you know, in
in the
general, you know, society, this is a little bit fringe still, right?
This idea of biohacking, this idea of, you know,
being able to sort of manipulate our biological age and sort of turn back
our biological age is something that, you know,
not if you're a billionaire tech person right there doing it all the time,
but for the most of us, this is relatively new
and it does come at a cost, right, to these tests are not inexpensive.
They're what, ballpark?
$300.
If you buy two kits, it's $300 per kit for most.
If you buy just one, it's 349.
Okay.
So, you know, it's certainly something that, you know, but I would say.
Costs will. Come down.
Right? Costs will come down in the future.
Right.
So just like any other technology, when you first start,
the cost is is higher.
And as time progresses, the costs will go down.
And and we'd like to provide that to customers.
But to your point about tech billionaires and,
you know, trying to hack their aging, that's what the press loves to cover.
But we as a company know goes we're a public benefit corporation
with my my childhood experience or my teenage experience.
It's very important to me to
to be able to offer to to the public the ability to,
first of all, the knowledge to understand that aging is in your hands.
You can control the rate at which you are aging too,
with within certain limitations, of course.
And and with that knowledge
give you free ways to be able to slow down your aging.
So to the point about the, you know, the the expense of the biological age kit.
Yes, of course.
Like if you are really getting into it, you might want to make that investments.
But even if you don't, we provide very practical guidelines for things
that you can do in your everyday life, from your diet to your exercise,
to your sleep routine to your strategy meeting, go down
the list of the things that science has shown.
Exhibit positive effects on your biological age
and biological rate of aging,
and you can do that completely for free on our website.
In fact, something that your listeners might be really interested in
is we offer a free tool called Face Age.
This is a you take a selfie, it's AI powered,
and the artificial intelligence is going to evaluate your selfie
and tell you how young your face looks, how young your AI age is.
And then other skin health markers like wrinkles,
skin redness, pore size, etc.
And then we give you practical guidance for improving all of those scores.
And you can track this over time, of course.
Right.
So so that's that's one thing that that a lot of people are really interested in.
And then we also have on our website a quiz that you can access
at the top of the website where you just answer a questionnaire
and then we give you personalized recommendations for what you based on
your lifestyle, need to focus on most to slow down your pace of aging.
None of this cost a sense we pay for it out of our pocket as a public
benefit corporation and then, of course, we hope some of you turn into customers.
But regardless, we want to provide this to the public.
I want to backtrack on what I said before.
So I will say, like I did one of these biologics that's not from Novo,
although I am interested in trying yours out, because the one that I did was
that was a saliva based, but it did give markers for various areas.
So my brain, my liver,
my metabolism
of of where that biological age was.
And I will tell you, it, it, it, it was
it was good enough to start me
on the road to some better habits.
So like, my liver was a little bit older. Well, guess what?
You know, you've heard me talk about, like those nightly tequila drinks.
I had to give those up.
That was kind of a bummer, but, you know, so it's good to kind of
have that as a marker for good behavior.
I think if you're ready to sort of take on some sort of a big change in your life,
if you're about to embark on a fitness journey,
if maybe you had some sort of a health scare that you need to
change your behaviors.
I always think it's a it's a great idea to kind of have this as a baseline.
And then how often do people normally take these?
Is it every six months?
Every year? Every two years.
So so if we were trying to maximize profit, we would say
take it every three months.
But the truth is, I suggest that everyone consider taking it once a year.
The reason being that you have to think of yourself
as an end equals one scientific experiment and being number of participants, right?
Like one participant in this scientific experiment and that participant is you.
So you have a very different
lifestyle in the winter, let's just say before Christmas
than you do in the summer, let's say for July 4th weekends, right? And
different
amounts of time outdoors with UV radiation, physical exercise,
different diets,
different drinking habits, different stress levels go down the list.
And those are known in science as confounding factors.
These can all kind of mess up the results and
and lead you to false
conclusions like, oh, maybe the lifestyle that they changed
to or the product that I'm using, the supplement I'm using isn't working.
Well, no, maybe it's actually that you're a lot more stressed this time of year
or you're not physically active enough, Right?
So to minimize confounding factors, we suggest that
you take the test at the same time the following year.
Now, if budget permits, of course,
you can take it once every six months or once every three months.
I wouldn't do it more often than once every three months.
But once a year, I think is a healthy balance for budget
and for the value that you can get out of taking in a test.
Now, given that you just said, you know, it's lifestyle,
maybe you don't want to do this on January 1st, right?
So for all of my people who are like, I'm starting something new,
but coming out of those holidays when you're probably, you know,
drinking, partying, maybe eating foods that you don't eat,
maybe not the best time to take it.
Yeah, probably take it to get one.
That's like a better depiction of what your real life is actually is.
Now, the needle is not going to move in in just like a day
or two of unhealthy eating.
But and so if you're if you're like me, I eat pretty healthy most of the time.
But then for Christmas,
I might Christmas Eve and Christmas Day, I might eat unhealthy.
But I'm not I'm not doing that for weeks.
I'm doing it for a day or two.
That's not really going to move the needle on the test.
But for others who might like not eat healthy and exercise for the whole month
of December, let's say, yeah, maybe wait a little bit longer.
Also, keep in mind
that if you were recently very sick, like, yeah, COVID or the flu,
you probably want to wait at least a month before you take the test
because your immune system
and the inflammation in your body might have an impact on the results as well,
which is not commonly talked about, but it's something that we suggest
to customers.
That's that's great to know.
You know, so so given this now that we've covered
the fact that we can have a different biological age, that we can control that
to some degree, what are some of the things that we can be
doing to sort of turn back that biological clock?
Yeah, So so
first, let's start with diet and and eating in general.
So meal timing is is being understood
as a very significant impact on your health
almost as much as the foods themselves.
Not quite as much, but almost as much so.
So when I say meal timing,
you may have heard of something called intermittent fasting.
Technically, it's time restricted feeding.
If you want to be accurate about the the term for it.
So time restricted feeding is eating only within
a certain time slot each day.
And so what you'll oftentimes hear is a ratio like for example, 16 eight.
That's what I follow.
So 16 hours of fasting, 8 hours of eating.
So that would mean, for example, eating only between 11 a.m.
and 7 p.m.
This is something that's very doable for most people.
You don't eat the first thing when you wake up, or
if you do, then you finish your last bite
earlier in the evening and you go longer without food.
So trying to compress that window
to approximately 16 eight would be would be a really healthy move.
Fasting is another another thing to consider.
Now, I would only suggest fasting to people who are in proper condition
to fasts like so, for example, if you're if you're a female
who has very low body fat percentage, I would consider not fasting
because it's probably going to just regulate your hormones.
It go ahead.
You know, I'm glad you bring this up because,
you know, I think that a vast majority of my listeners are women.
We've talked about intermittent fasting, but I have heard that
for men, intermittent fasting is a wonderful, wonderful thing.
I've heard that it's actually not so great for women.
Have you heard differently or do you have thoughts on that?
Yeah, so so I have heard it.
I haven't seen any specific scientific studies on it, but just anecdotally,
I have heard it a lot of times from friends and on the Internet.
What it seems to be is that women have have different hormonal cycles,
obviously, than men and different ratios of hormones than men. And
inches
biologically, like evolutionarily, like women are to be,
you know, carriers of children, of babies to be pregnant.
Right.
And so men don't have those requirements.
And and so so it seems that by having
by by fasting excessively too much.
What is that actually doing?
It's sending a signal to the body that food is scarce.
And if you think in the evolutionary context
and biology, if food is scarce, nature doesn't want you to procreate
because you then might die yourself or
the child a newborn might die.
Nature wants to incentivize you to only procreate once there's food
in abundance, adequate food to be able to support yourself and the newborns.
So that's my, my,
my expectation, my feeling as to why women might be more sensitive
to it than than men, because they would have to carry that child
and they would need adequate food to carry that child
for for males, they don't
seem to be as sensitive to it, though I can say me personally,
if I fast too much or I'm too hypo caloric, so not enough calories each day.
I definitely feel the difference in terms of the quality of my sleep.
I'd say my mood changes so I'm not as happy.
I am more like focused,
but not as like positive and so on.
So I can notice these subtle changes in myself.
And so I need to make sure I balance the health versus like
quality of life and, and those around me to make sure better.
Yeah, but, but certainly, yes, there are a lot
there's a lot of research out there.
I would just caution, you know, especially the women look into intermittent
fasting always talk to your doctor because I've heard both things right.
So I know that it it I know that in the, you know, sort of this
biohacking community,
that intermittent fasting is is definitely something that people employ.
We've had great podcasts on intermittent fasting here on this show,
but I have also heard from some doctors
who've said, I don't know if it's great for women.
Yeah, yeah.
So, so technically intermittent fasting would be time restricted feeding,
but it would require that you're eating fewer calories than you typically would.
And so if if you are intermittent fasting by the strict definition of the term,
which means you're eating fewer calories, I can see that as being a concern for
for your female audience, particularly if they're not already overweight,
they're overweight, they have excess calorie storage.
Right.
And they can probably get away with it more so than thinner.
Women can.
But if you're doing time restricted feeding
where you're not reducing the calorie intake,
you're just reducing the eating window that I don't think
women will be as sensitive to, hormonally speaking,
because if you eat the same number of calories that you would otherwise eat,
you're just eating them between 11 and seven instead of from 9 to 7.
Let's say that shouldn't really have that much of an impact.
But if you're reducing your calorie intake, which naturally oftentimes happens
when you're eating in a smaller window because you get fuller quicker,
then that's where there could be some trouble.
So the calories, I think, are the critical the critical issue for that.
Thank you for clarifying that.
I really appreciate that,
because that makes much more sense with the time restricted.
You know, when you said that my mind went to intermittent fasting,
but it's not the same thing.
And boy, you know, 11 to 7 does seem very doable in the outside windows.
Can you still be drinking water?
Yes, Yes, of course.
So just no, no food, but you can be drinking water throughout.
You can have. Water.
You can even have black coffee. Right.
So not with the milk.
Latte and not now by morning, all.
Day, but black coffee, you could throw it.
You can probably even throw some stevia in there. Right.
So it's zero calorie doesn't raise your blood glucose.
So we want that a little bit sweet.
But yeah, none of the creamers or milks in there.
Okay.
So in addition to diet,
what are some other behavioral changes that we could be making
to sort of help turn back that biological clock?
So so within the topic of diet is the food itself that you're eating, right?
So I'll just say the obvious stuff is like minimize processed foods,
eat as as much stuff straight from the earth as you can.
Don't go excessive with with meats, especially red meats
in fact, the best diet you can follow are the two best diets.
I should say that the most commonly known one is the Mediterranean diet,
which is, you know, the eating style of Mediterranean named regions.
But then we have our website, the NOVOS
Longevity Diet, which takes the Mediterranean diet as its foundation
and then make some tweaks to it based on the latest research
to to improve it even further.
So we would suggest people take a look at the Noble's longevity diet.
But the Mediterranean diet is something that that is
I think most people would enjoy eating in the first place.
Right.
It's it's a very satisfying diet
and it's not so restricted like something like a ketogenic diet might be.
So then beyond diet, obviously exercise.
Now the question is how much are you going to exercise?
And what is the ideal versus like the minimum effective dose.
So the ideal would be that your weight lifting, let's just say three days
per week, you are doing some form of cardio, ideally every day.
Now that cardio doesn't have to be high intensity
or high heart rate zone cardio every day.
So in other words, zone to cardio, which is when your heart rate is,
I believe, around 70% of your max heart rate in that in that neighborhood.
If you're doing that for, you know, 25 minutes
a day is the approximate minimum that you want to do.
But if you can do even more than that, great.
It's not really putting that much stress on your body,
but it is very healthy to be in that zone, too.
So doing as much as that, as much of that as you are willing to do.
But at least about 25 minutes per day is going to.
It's like Perritos principle, that 80/20 rule.
You're going to put in 20% of the effort and get 80% of the benefits
when it comes to longevity and slowing down aging, you'll largely
get that from doing this zone to cardio every day.
Plus the weight lifting.
Is, don't you?
Are we talking about like a brisk walk?
Is that a jog? You know, for most of us.
It's going to depend on your
fitness levels for for some who are not particularly fit.
That's just going to be a brisk walk. Right.
So a way to think about it is you're you're breathing heavily,
but you can still breathe with your mouth closed
and you can have a conversation with somebody like you can say
a full sentence without being winded.
But when you finish the sentence, you're going
to need to take a gasp of air, Right?
So you're like in that range.
And so obviously, if you have something like an Apple
Watch or a heart rate monitor, you can actually track and see which there you go.
So you can easily see what heart rate zone you are in
when you use the fitness setting on the the Apple Watch.
But otherwise, that simple test of like, can I can I say a sentence and can I
can I do this with my nose closed but still feeling the pressure of
faster breathing that's probably getting to that zone too.
Amazing.
So we're looking at what, like 100 and 2040 minutes a week.
You said about 20 minutes a day.
I believe the exact number
I calculated was like 23 minutes, but I just round up to 25 minutes a day.
25 minutes a day, seven days a week.
Yeah.
I mean, if you take a day off here and there, that's that's fine.
Like I personally work out six out of seven days per week
and then one day on Sunday, it's my day of rest.
But I will still
I'll still walk a good amount or I'll do like a leisurely bike ride.
So I might not be in zone two, but I'm physically active.
I'm still moving.
I'm laying on the couch all day long.
So you don't have to be like perfect about it.
But yeah, most days,
five or six days a week, if you're doing that, that's that's great.
And that's like the minimum effective dose for like slowing down the aging.
I think everyone can do it.
They just need to have the form, the habit to, to do it.
Like I for example, every morning I will do a light jog to be in zone
two cardio and I'll listen to a podcast, for example.
Right.
So that's like instead of sitting at home listening to a podcast like I do it by,
you know, doing a light jog.
So try to create like a ritual out of it, something that you enjoy doing while
doing that jog, which will then increase the likelihood that you'll adhere to it.
Okay.
So I want to make sure that we have time for some of these supplements because,
you know, that's a lot of what I think people are looking towards these days
is, you know, in addition to having a good diet, in addition
to having, you know, getting proper amount of exercise, getting enough sleep,
what are some of the new technologies that are out there?
You know, and I know Noble's has two products here.
You've got Core and NOVOS boost.
I want to make sure we get to talk about this.
So, so so tell us a little bit about this supplementation, why we need it.
What are the things that we should be taking?
Sure.
So so let me set the context first so people get confused about supplements
and sometimes
they think NOVOS is a multivitamin and they say, what's the difference
between a multivitamin in this?
So the context is we think of supplements
in the form of general health supplements.
This is the stuff that you need just to to be generally healthy.
This is what the government has said an RDA for.
It's like vitamin C, vitamin E, vitamin A,
magnesium, potassium, the B, vitamins and so on.
Right.
And this you can get from a multivitamin,
you can get it from the foods that you eat.
And we do suggest that everyone look into supplementation because most
almost definitely you're not getting adequate nutrients
just from your diet alone, no matter how healthy you eat, myself included.
I still need to supplement.
That's general health supplements.
Then you have
targeted supplements for specific goals.
So you have like maybe a pre-workout supplement or a post-workout supplement.
Maybe you have a
a supplement focused on reducing your anxiety
or just keeping you calm or helping you sleep at night.
And then you have the category of longevity supplements.
And this is where Noble specializes.
So we focus on creating formulations that are going to slow down
your biological pace of aging and the way that we do it, the way
we approach it is based on what's known as the mechanisms of aging.
Or put another way, the 12 biological causes of aging.
These are the causes that scientists over more than a decade of work
have put together as the reasons from a microscopic level why we age.
These are the things that start to go wrong
biologically as we age
and we want to slow down
their degradation as much as possible, which if we can do that
across
all of these different hallmarks simultaneously,
we're going to stand the best chance at slowing down the aging process
because they're all interconnected, they feed off of each other.
And if you only slow down one of them, you're not going to have
that much of an impact compared to if you slow down all of them.
Think of the analogy of a car, an old car with like tires
that are flat and rust all over them and the engine doesn't have oil in it.
If you just fill the tires up, you're not going to get very far.
But if you clean up everything similar tenuously,
that's when you're really getting the car in good condition to drive again.
So we are the first company, the only company to create
a formula to address all 12 of these hallmarks simultaneously
across all industries, including biotech and pharma.
We're over the counter, of course, but we're the first company to ever do this.
We have a scientific advisory board of scientists from Harvard and MIT
and the Salk Institute that study aging and helped us with this formulation.
We filed four patents on this formulation and we've done a number
of different scientific tests on the formulation and case studies.
So, for example, a case study we did,
we administered Noble Score and boost
to the participants and 73% of them slowed down
their biological pace of aging by a statistically significant margin.
So it wasn't coincidental.
In fact, the p value for the geeks out there who want to know the probability
that it was just a coincidence versus it being the supplement itself was 0.001.
Typically in science, you need it to be 0.05.
So this was 50 times more reliable than the typical standard
for scientists to conclude that something was coming from from the
from the intervention in this case being de novo supplements.
And 0% of people accelerated their aging, which is also important to know
because you have these stressors in life, right.
And different different things, whether it be literally stress or excess
drinking or not eating healthy or whatever it might be,
you would expect some people would have accelerated, but nobody accelerated.
Everyone that either stayed the same
or the large majority actually slowed down their pace of aging.
So that was the case study.
We have clinical trials underway.
We've done in vitro studies to to show that we reduce DNA damage
from irradiation.
We reduced cellular senescence.
These are important for skin health. Right?
So DNA damage is what really starts to break down the collagen
and the matrices in our face.
And then we start to wrinkle and our skin starts to age
and we reduce DNA damage in an in vitro study
by administering a noble score.
And we also reduce senescent cells, footprints.
So senescent cells are these zombie cells that start to accumulate
as you get older.
Typically it's that the the cell is damaged.
It's it's not functioning properly.
There might be DNA damage.
It might actually even be a cancerous cell.
And so the body will actually turn that cell senescence.
It kind of arrest that cell.
But the problem is that cell secretes inflammatory molecules
that cause nearby cells to get damaged and then become senescent, too.
So as we age, that increases exponentially.
It's one of the top targets for skin care companies, is to reduce
senescence in skin because it leads to the rigidity of the skin.
And then again, wrinkles can form from it.
So we found in a study done at Newcastle University
that we were able to reduce the size of senescent cells
by approximately 50% or so
and and presumably with also reduced the progression of cells
because of the DNA protection that I mentioned earlier.
So we're just getting
started with the studies, but so far they're all very positive in our favor
for Novos doing something significant for the aging process.
Amazing.
And there is a lot of talk right now about an end and end and
I know that there's some talk
that the FDA is trying to turn this into a drug.
Are you worried about that at all?
So there's only so much I can say.
It's technically there is a scientist, a well-known scientist
in the longevity field who is a founder of a company
that is trying to monopolize this substance and make it prescription only.
So this person has talked a lot about and a man and brought the public's
attention to it.
And then multiple companies, not only us, but others, have invested a lot of money
into building out this this the product
and marketing the product and getting it into the hands of consumers
only for this person and the company they're affiliated with, technically,
to try to work through the FDA, through a loophole, to try to take it off
the market.
The FDA in closed door discussions, has said that it's
not a matter of safety, it is simply a commercial topic.
So, yeah, we will.
We'll see where it goes, but we're continuing to sell it for
as long as we're able to, and hopefully it doesn't turn into a legal matter.
But if it is, we're ready to protect our consumers to be able
to purchase this natural substance, which I should mention is in our bodies.
Right?
We produce and I mean,
naturally, it's also in our food supply, like tomatoes have any men in them.
But the levels decline as we get older.
And so we don't believe it's fair for a biotech company
to be able to monopolize it and make it prescription
only when it is something found in nature and in our bodies.
No. And, you know, I wish we had more time to get into this.
Can you quickly over
and and and some of the benefits I know that were kind of
I want to be mindful of your time.
Sure. Yeah. Sure.
So so MMN is a precursor
for another molecule in our bodies called NAD Plus.
And NAD is is a molecule that's responsible for many different processes.
So being a precursor and fuels the creation of the energy.
And the energy is involved in many different processes,
including the production of sirtuins and sirtuins
can repair DNA, right?
So when you're out in the sun and the UV rays are damaging your DNA
and causing mutations, we actually have mechanisms in our body
to be able to go and repair that DNA rescue, that DNA to prevent it
from turning into, in the worst case, into like a carcinoma, right into a
into a melanoma.
So NAD
is is the fuel essentially for those sirtuins.
So that's one thing it does, but it is also involved in the Krebs cycle.
So you might remember from high school biology
that the Krebs cycle is the process through which our bodies produce energy.
So you take those carbohydrates, that protein to a lesser extent,
but still you can get energy from certain forms of protein and fat.
And the Krebs cycle is what is then
producing ATP,
which is the energy currency that our cells use,
our brain uses, our heart uses to be able to perform their functions.
And so our need is is a critical component of that.
So other benefits can include improvements in energy.
There's there's research being done,
finding reductions in or I should say improvements in health span.
So different aspects of the aging process to be able to
improve healthy living essentially over the long term
is some of the promise that the animal and molecule holds.
And I thought that there was a lot of promising research in the field
of Alzheimer's, and that's sort of where this this drug battle is kind of coming.
And so listen, for my listeners out there, I maybe can't say this
I'm not a doctor by any means, but I've done some research.
This seems like a very, very promising
I don't know what you call it, a supplement.
Yeah, I mean, it is a supplement.
But it it's a promising one.
I would say. Get it while you can
and Noble Score certainly has.
So I write the novels.
Bruce has a very high quality, reputable one.
You can read all about it on their blog and on their website.
You know, Chris, I want to thank you so much.
I feel like I could talk to you for hours and hours and hours about this.
I think that we are at the start of like, you know, longevity
is going to become very mainstream in the very near future.
If people want to know more about Novos, where can they go.
So they can go to Novo slabs dot com.
We're also on all of the social networks as Novos Labs.
And then me personally, I also have a blog Slow My Age
where I post my my results in my lifestyle hacks and so on.
That's a little bit more geeky, not as mainstream as as the Novos website.
And I'm on Instagram and Twitter as @slowmyage as well.
I want to thank you so much for being with us today.
This is so awesome. I mean, I'm just fascinated.
I got to check out your blog.
You know, definitely check this out.
If you have questions you want me to pass on to Chris, I'm always happy to do so.
You can email me at hello@artbeautypodcast.com.
You can find us on Facebook, Instagram and YouTube @artbeautypodcast.
And as always, we will see you next Tuesday.
Bye! .