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Hi, Welcome Bc Cattle on Brad White happy

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to have you with us And happy to

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have our guys here in the studio today.

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Good morning, Bob. Good morning. Good morning, Philip.

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Hey, guys. We're glad that you guys are

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here. We've got a couple folks out today,

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but We've still got plenty to talk about.

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In fact, I've got some questions for you

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guys.

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Also, we've got a listener question that was

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about...

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Utter development in He and nursing. And then

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we are gonna get Brian back in and

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have him discuss how antibiotics work. So pretty

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big question for Brian. So we'll wait tiny

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back in for that 1. But we will

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be able to address that before we get

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into those, I wanna remind you if you

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have questions, comments, things you'd like us to

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talk about, You can send us an email

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at bc at KSU dot EDU.

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And before I get into my even more

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random questions. I do have 1 for you

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guys. I was

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in charge of dinner last night, and I'm

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afraid, I don't have a lot. In my

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toolbox as far as being able, so we

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had burgers. Mh, which is not surprised. But

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I thought I would pick your brains. When

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you're left to make dinner for the family.

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Do you have anything I could do... Now

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remember? My skill set is low.

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So what could I cook for the family

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besides burgers, and don't say steaks because I've

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already got that 1 down too. That that

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that was gonna be my answer. Okay. It's

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gotta be pretty simple. Can you follow a

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recipe

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for Not really. Oh, boys.

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Like you trouble. When... Let's see there's craft

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mac and cheese. Yeah. Amber helper. Yep. Yep.

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What just kind of an egg scramble. You

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just... You scramble a bunch of eggs and

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then you open the fridge and see what

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else is in there, maybe some

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bacon or... It's chop ups some veggies and

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stuff. You can always kinda do that egg

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scramble, and that's kind of a... That's kind

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of a last minute. I can't kids don't

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like them black, though. That's all can truth.

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You do have it. Can you do pancakes?

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Mean you can do breakfast? No. I don't

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I don't like breakfast for dinner. Yeah. Alright.

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See you could see why my difficulties is

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coming from. Yeah. It may be so far

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I'm thinking call in the pizza place. Just

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starting to look about. The best you're gonna

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do. Alright. The burgers were excellent. Yeah, bet

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they were. So...

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Well,

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that will lead us directly into... I do

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have some questions for you guys, And and

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we'll do this where we've gone through before

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relatively short as we go through, because I

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have several questions for you. And it's Philip,

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I'm gonna start out with you.

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If we're in a situation, some are grazing

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and you guys can either 1 jump in.

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But some are grazing, I've been putting mineral

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out all year, and then my mineral consumption

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has dropped by quite a bit. So I'm

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not putting mirrors as much out.

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Is this something I need to worry about?

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Do I need to move the mineral feeder

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changed to a different type of mineral? Or

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do I assume? Well, if they're not eating

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it, they're getting it somewhere? Well, I don't

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know that you can assume that generally. Because

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generally, they're gonna consume mineral based on salt.

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So probably the reason they're not... Assuming mineral

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is because they're getting plenty of salt through

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the forage or somewhere else.

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So,

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we probably need to to think about how

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to get some mineral into them. So this

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time of year, I mean, we're in the

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summer probably starting some summer

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supplementation subtype types and pro... Protein supplement.

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So have the mineral mixed right into your

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protein supplement is the best strategy, and then

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you they're gonna consume it right along with

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the protein up. Yeah. Control their control consumption,

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and be sure that if I've got it

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placed, it's placed

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high traffic. Area. So near the water, somewhere

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they can get to or somewhere they'll come

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to get it. Bob, next question for you,

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carry

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fly control,

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back rubber

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or get everyone in and individually apply an

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insect side.

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Well, You know, first of, I've I've worked

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with producers that have made a lot of

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different methods of flight control work. And so,

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you, I'm not gonna actually argue with anybody

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that has figured out a system that works

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for them. But I do like a back

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rubber in that,

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I think most cattle will use it, particularly

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again, it does have to be placed in

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the right place place in an area where

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they're gonna walk. Through anyway.

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And I do have to make sure that

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it's charged and that I've kept it full.

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I mean, so there's a little bit of

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work involved but it does allow cattle to

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basically,

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self medicate every day,

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or nearly every day, And I... And that's

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1 of the things I really like. It's

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relatively inexpensive way that... If it's placed right

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and it's charged and and kept up, it's

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a pretty good way to provide a, frequent

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fly control, and, you know, you know, there's

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stuff I like and don't like about every

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method of flight control. 1 of the things

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I don't like about ear tags is You

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start with 1 dose and then that dose

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gradually declines over the summer. When you're using

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a back rubber again as long as they're

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still insect insecticides out there, I'm I'm keeping

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the same dose throughout the summer. And so

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I I really like that. Yeah. The struggle

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is making sure that they all use it,

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and they won't all use it. So you

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have to you have to figure out whereas

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if I apply, your tags are insect insecticides,

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I gave all the same dose. 1 point

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in time. Which is I I said there's

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there's positives and negatives for any way you,

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provide the flight control and getting them all

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in and doing a a spray or a

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pour on. I That's a way to ensure

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that every animal gets it, but I'm gonna

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have to repeat that pretty frequently, and that

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becomes very labor intensive. But you also said

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you would argue with anybody about it than

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you argued with. Well, I'm I'm just saying

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there's always a plus in am mine. Nice

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bro account. Alright. Philip up, next topic for

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you,

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rapid cool season

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grasses.

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I that we're growing rapidly,

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tried grazing them couldn't keep up with them.

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So now I have a mix of some

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areas that are

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g really well. Some areas where it's gotten

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too

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mature.

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Give me some ops should I go in

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and try to make hey in this scenario,

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should I continue trying to grade it even

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though it's gone to mature, Should I try

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to mow it in the cool season scenario?

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So

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at this point, we're probably past the idea

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of paying a cool season forage.

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So

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at probably,

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1 thing we could try to do though

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is we... Thing on your situation, if you

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can adjust the size of your pastors or

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your pad.

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To

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shrink them down quite a bit, and we're

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gonna go more intensive grazing

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where we're gonna really... We're gonna force those

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animals to

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consumes some more of that,

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older mature forage, at least tram it down,

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and as they're in there, So that then

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once we start to get a little cooler

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weather here a little in another month or

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so, we get a good free growth, a

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good flush of... Of good cool season forge

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again. So I wanna get rid of that

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stuff.

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I could go in there and I can

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mow it off with a brush hog or

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something like that, but that's gonna be fairly

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expensive,

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but I can do some things about managing

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the intensity of my grazing.

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And I also need to to probably do

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a little bit of that anyway is where

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I'm allowing some of those pastors to get

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longer rest as that growth rate slows down

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in those cool season voyages in the... With

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the hotter weather. Yeah. Trying to trying to

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get them to utilize it, which

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utilization may involve consumption

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or tram. And so that way I get

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the that plant to put up some new

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leaves and shoots and stuff when it cools

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off. Yep. Absolutely.

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So last question for you, Bob is pink

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eye related, and both of you and I

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have been frustrated by this disease and and

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we see it. And and specifically,

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when we think about

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identifying it, give me some things I should

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look forward to

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identify it in individuals and maybe determine

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Which 1 should I treat or not treat?

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Yeah.

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To deal with pink eye effectively, I'd like

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to treat it as early as possible. So

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as soon as you see some tearing in

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the eyes... I would I would get those

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calves and treatment them. Again, I know that's

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not easy. A lot times were out on

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pasture, and it's a it's a difficult thing

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to ask,

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but

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It's not gonna get better on its own

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for a while. And so if you... You're

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gonna see it progress, and you'll you'll see

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some ulcers in the eye, you'll see more

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pain more. More calf performance losses. So the

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main thing is so as soon as you

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see any watering in the eye and you

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go well, it doesn't really look cloudy yet,

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it doesn't look red, treat it now. Treat

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it as soon as you see the watery.

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Exactly. And I think I think your your

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point there is this disease develops very, very

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rapidly. So you'll see that that progression from

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tier to have an a corn ulcer or

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scratch on the surface of the eye

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happens really quickly. Sooner we get them in,

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the better we have a chance of of

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a good outcome. Yeah. Exactly. And the the

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success of treating 1 so that...

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There's quite a bit of damage to that

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eye. Our antibiotics probably aren't gonna make as

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much difference as they would have much earlier.

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Now sometimes we'll put a patch on them

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and we'll do some other things that that

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provides some relief, but we would have been

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a lot more effective if we had treated

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it earlier. Absolutely. Great answers, guys. Good good

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answers to those questions.

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And now I wanna hear your answer to

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a listener question.

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And this question is a really good 1

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because I think it involves a a couple

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different facets here.

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And they had a situation where they had

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he

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that were about 3 months bread. They went

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ahead and turned them in with the main

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herd. Makes it a lot easier management wise.

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The challenge that they're running into is some

266
00:09:22,450 --> 00:09:24,675
of the young calves that were born from

267
00:09:24,675 --> 00:09:25,969
cows in the herd

268
00:09:26,358 --> 00:09:28,450
are now trying to nurse those He

269
00:09:29,463 --> 00:09:31,691
couple parts of this question. Do I have

270
00:09:31,691 --> 00:09:33,920
concerns that this is going to mess up

271
00:09:33,920 --> 00:09:35,852
the He utter development

272
00:09:36,402 --> 00:09:38,469
And 2, what do I do to get

273
00:09:38,469 --> 00:09:40,854
the caps from to stop doing this. So

274
00:09:41,013 --> 00:09:42,922
Bob, I'm gonna turn to you first. Which

275
00:09:42,922 --> 00:09:45,008
can I answer either 1? Yeah. You answer

276
00:09:45,008 --> 00:09:46,127
the easy 1 we'll give the hard 1

277
00:09:46,127 --> 00:09:47,725
fill it? Yeah. Well,

278
00:09:48,844 --> 00:09:50,442
will it cause some problems to their editor

279
00:09:50,442 --> 00:09:52,200
development? I... I'm concerned that it could.

280
00:09:53,168 --> 00:09:54,993
And 1 of the things I'm concerned about

281
00:09:54,993 --> 00:09:56,898
developing the mass dye or something else like

282
00:09:56,898 --> 00:09:58,961
that. And so This is... I'm not gonna

283
00:09:58,961 --> 00:10:00,627
let this stand. I'm gonna try to...

284
00:10:01,598 --> 00:10:04,230
And probably that means, the easiest way to

285
00:10:04,230 --> 00:10:05,665
make sure that it stops is to remove

286
00:10:05,665 --> 00:10:06,942
those he out of it. I think I

287
00:10:06,942 --> 00:10:08,298
was fine to put the he in there

288
00:10:08,298 --> 00:10:10,212
with the cows when they're on growing... Green

289
00:10:10,212 --> 00:10:12,217
growing grass But we've run into a problem.

290
00:10:12,455 --> 00:10:14,363
I think it's time to adjust that plan

291
00:10:14,363 --> 00:10:15,953
and and actually pull them out and put

292
00:10:15,953 --> 00:10:17,622
them where they're not with those calves. I

293
00:10:17,622 --> 00:10:19,053
think you're right. And and from some of

294
00:10:19,053 --> 00:10:22,328
my conversations the... We we often don't see

295
00:10:22,328 --> 00:10:22,828
mas

296
00:10:23,441 --> 00:10:23,941
in

297
00:10:25,110 --> 00:10:28,210
mature cows, but you certainly can develop it

298
00:10:28,210 --> 00:10:29,934
as a he if they're nurse on it

299
00:10:30,054 --> 00:10:33,231
other playing around and see those situations. Philip,

300
00:10:33,311 --> 00:10:34,979
what are what are your thoughts as far

301
00:10:34,979 --> 00:10:37,044
as... So bob Bob said, maybe get the

302
00:10:37,044 --> 00:10:38,950
he out of there will help solve the

303
00:10:38,950 --> 00:10:41,618
problem. Does and that he's concerned about.

304
00:10:41,997 --> 00:10:43,516
What are your thoughts on this 1? Well,

305
00:10:43,755 --> 00:10:45,433
I think 1 of the first questions I

306
00:10:45,433 --> 00:10:47,751
ask, why are they nursing on a effort

307
00:10:47,751 --> 00:10:49,210
that has no bag

308
00:10:49,761 --> 00:10:51,929
she's got no other development. She's

309
00:10:52,699 --> 00:10:53,732
providing no milk.

310
00:10:54,844 --> 00:10:56,750
It is the 3 months bread as a

311
00:10:56,750 --> 00:10:56,988
he.

312
00:10:57,639 --> 00:11:00,027
So why are they nursing on her instead

313
00:11:00,027 --> 00:11:01,460
of the damn? I mean, I can I

314
00:11:01,460 --> 00:11:03,291
can see them maybe going to nurse as

315
00:11:03,291 --> 00:11:03,848
just a

316
00:11:04,405 --> 00:11:06,966
a comfort reflex? The dams were not no

317
00:11:06,966 --> 00:11:08,875
longer in there, but they're dam that's producing

318
00:11:08,875 --> 00:11:10,148
the milk is in there. So the question

319
00:11:10,148 --> 00:11:12,239
is why are they... And so

320
00:11:12,708 --> 00:11:15,489
are my are my mature cows thin? Have

321
00:11:15,489 --> 00:11:17,555
they really backed off their milk production,

322
00:11:18,588 --> 00:11:21,071
you know, start figure out maybe why those

323
00:11:21,071 --> 00:11:22,985
calves are wanting to nurse on those he

324
00:11:22,985 --> 00:11:24,899
instead of nursing on their dams. And so...

325
00:11:25,936 --> 00:11:27,291
And maybe I need to provide a creep,

326
00:11:27,451 --> 00:11:29,778
Maybe I need some additional nutrients, of those

327
00:11:29,778 --> 00:11:32,483
calves if my cows have really backed off

328
00:11:32,483 --> 00:11:34,075
in their milk production or something. But they

329
00:11:34,075 --> 00:11:36,224
you start figuring out maybe why that's is

330
00:11:36,224 --> 00:11:37,895
happening and them... Because there may be more

331
00:11:37,895 --> 00:11:39,822
to it than just so I need to

332
00:11:39,822 --> 00:11:41,656
protect the other development of the he.

333
00:11:42,853 --> 00:11:44,767
I need to figure out Mh. Why my

334
00:11:44,767 --> 00:11:47,000
calves are doing it because it's it made

335
00:11:47,000 --> 00:11:48,936
very well be a nutritional deficiency

336
00:11:49,487 --> 00:11:51,479
thing they're just hungry. So we... And I

337
00:11:51,479 --> 00:11:54,288
think that's an important distinction is on the

338
00:11:54,426 --> 00:11:57,236
sign of the problem is the cab nursing

339
00:11:57,293 --> 00:11:59,718
he, but the actual root to the problem

340
00:12:00,093 --> 00:12:01,923
maybe the milk from the dams is what

341
00:12:01,923 --> 00:12:03,991
you're saying. So first you... First shoot check

342
00:12:03,991 --> 00:12:04,707
body condition,

343
00:12:05,517 --> 00:12:07,343
also wouldn't be opposed to getting some of

344
00:12:07,343 --> 00:12:09,327
those cows in if you can't see their

345
00:12:09,327 --> 00:12:11,074
ut well or even if you can see

346
00:12:11,074 --> 00:12:13,551
their at well and make sure that, she's

347
00:12:13,551 --> 00:12:15,858
actually got the milk that is necessary for

348
00:12:15,858 --> 00:12:16,734
those calves,

349
00:12:17,609 --> 00:12:19,280
because that may be kind of the root

350
00:12:19,280 --> 00:12:21,446
because this is not normal. Behavior and that

351
00:12:21,446 --> 00:12:23,439
they would be trying to trying to nurse

352
00:12:23,439 --> 00:12:25,933
on. Now it is relatively normal

353
00:12:26,389 --> 00:12:28,542
that they'll once in a while, swap dams

354
00:12:28,542 --> 00:12:30,393
and still a bite here or there. Right?

355
00:12:30,553 --> 00:12:32,471
I mean, that that will happen, but you...

356
00:12:32,710 --> 00:12:34,388
I wouldn't expect them to be going towards

357
00:12:34,388 --> 00:12:36,167
those he because those he

358
00:12:36,626 --> 00:12:38,554
at this point should have nothing in there

359
00:12:38,634 --> 00:12:40,862
At. Right, bob Yeah. And and I am

360
00:12:40,862 --> 00:12:43,011
kinda just guessing what might be going on

361
00:12:43,011 --> 00:12:44,524
here. It could be a behavioral thing where

362
00:12:44,524 --> 00:12:46,513
the hep don't know enough to keep those

363
00:12:46,513 --> 00:12:48,600
calves away. Know, maybe the other cows are

364
00:12:48,600 --> 00:12:50,196
gonna, you know, kick, I'm in it could

365
00:12:50,196 --> 00:12:50,993
be pretty natural.

366
00:12:52,110 --> 00:12:54,662
So I... This is an interesting question because

367
00:12:54,662 --> 00:12:56,656
it... It's not typical. It's not normal It

368
00:12:56,656 --> 00:12:58,748
needs to be in negated. So III agree.

369
00:12:58,908 --> 00:13:00,586
But don't stop with just removing the he.

370
00:13:00,746 --> 00:13:02,744
Go ahead and figure out because if those

371
00:13:02,744 --> 00:13:05,221
cab are truly short on nutrition now. Can

372
00:13:05,221 --> 00:13:07,867
do address to address it. Yeah. Excellent. We'll

373
00:13:07,867 --> 00:13:10,089
appreciate you guys answering that question, and let's

374
00:13:10,089 --> 00:13:11,755
go ahead and get doctor Lube in and

375
00:13:11,755 --> 00:13:13,818
talk about antibiotics. Brian, I'm gonna turn to

376
00:13:13,818 --> 00:13:15,982
you first. We've had a couple listener questions

377
00:13:15,982 --> 00:13:18,314
along the same general theme and

378
00:13:18,769 --> 00:13:19,429
I'll para.

379
00:13:20,044 --> 00:13:20,862
They're basically

380
00:13:21,477 --> 00:13:23,800
how do antibiotics work. We've Seems like a

381
00:13:23,800 --> 00:13:25,310
pretty simple question that you should be able

382
00:13:25,310 --> 00:13:27,240
to answer in 30 seconds, but I'm sure

383
00:13:27,296 --> 00:13:29,362
you'll be able to expand a little bit

384
00:13:29,362 --> 00:13:31,190
further. Maybe a little bit Yeah. Maybe a

385
00:13:31,190 --> 00:13:33,189
little bit. Yeah. Give us a a little

386
00:13:33,189 --> 00:13:34,854
bit of background because I think the root

387
00:13:34,854 --> 00:13:36,623
of this question is

388
00:13:37,074 --> 00:13:39,295
how should I use them and when should

389
00:13:39,453 --> 00:13:41,143
I use? Them, but tell us a little

390
00:13:41,143 --> 00:13:43,621
bit about how antibiotics do work. Yeah. And

391
00:13:43,621 --> 00:13:45,459
and first of all, I think it's great

392
00:13:45,459 --> 00:13:48,176
that producers want more information and to be

393
00:13:48,176 --> 00:13:50,609
more knowledgeable, not. Just because

394
00:13:51,147 --> 00:13:53,065
they wanna do better on their operations,

395
00:13:53,705 --> 00:13:55,383
but a lot of times they get asked

396
00:13:55,383 --> 00:13:57,940
questions from consumers. And so, you know, if

397
00:13:57,940 --> 00:14:00,180
you're at educated user of antibiotics.

398
00:14:00,895 --> 00:14:01,951
I I think that

399
00:14:02,324 --> 00:14:04,626
portrays us in AAA much better light as

400
00:14:04,626 --> 00:14:06,690
far as how we use antibiotics and antibiotics

401
00:14:06,690 --> 00:14:09,337
stewardship. So I I think that that quest

402
00:14:09,337 --> 00:14:11,894
for information knowledge is great. And I'll I'll

403
00:14:11,894 --> 00:14:14,850
just say, I think probably the best resource

404
00:14:14,850 --> 00:14:17,598
is is talk to your veterinarian. And because

405
00:14:17,895 --> 00:14:18,852
a lot of times,

406
00:14:19,968 --> 00:14:23,078
the reasons why we might choose 1 antibiotic

407
00:14:23,078 --> 00:14:26,830
over another aren't necessarily related to activity. There

408
00:14:26,830 --> 00:14:28,260
there are a lot of factors we think

409
00:14:28,260 --> 00:14:30,326
about when we decide that this is the

410
00:14:30,326 --> 00:14:32,551
antibiotic we wanna use for this particular case.

411
00:14:33,203 --> 00:14:34,558
But to answer your question. So how do

412
00:14:34,558 --> 00:14:34,877
they work?

413
00:14:36,312 --> 00:14:39,182
Essentially, an antibiotic is is a chemical,

414
00:14:39,979 --> 00:14:41,037
and it somehow,

415
00:14:41,830 --> 00:14:45,350
interferes with bacterial growth or replication. That's the

416
00:14:45,350 --> 00:14:46,730
that's the most basic

417
00:14:47,429 --> 00:14:48,950
definition. And there are lots of ways that

418
00:14:48,950 --> 00:14:50,309
they can do that. Lots of different ways.

419
00:14:50,470 --> 00:14:53,137
So we have We have antibiotics that inhibit

420
00:14:53,513 --> 00:14:56,379
bacterial cell wall growth. We have antibiotics that

421
00:14:56,379 --> 00:14:56,879
inhibit

422
00:14:57,414 --> 00:14:58,789
bacterial protein synthesis.

423
00:14:59,498 --> 00:15:01,509
We have antibiotics that inhibit

424
00:15:01,964 --> 00:15:04,826
bacterial replication by interfering with Dna and rna

425
00:15:04,826 --> 00:15:07,664
for the bacteria. And 1 of the things

426
00:15:07,784 --> 00:15:10,336
to keep in mind too. The antibiotics we

427
00:15:10,336 --> 00:15:10,836
have

428
00:15:11,293 --> 00:15:15,620
are good antibiotics because that they have selective

429
00:15:15,838 --> 00:15:18,872
activity against the bacterial protein synthesis,

430
00:15:19,268 --> 00:15:21,988
but not mammal million or human or bo

431
00:15:22,201 --> 00:15:24,991
protein synthesis. And so, you know, 1 of

432
00:15:24,991 --> 00:15:26,340
the questions we have is why don't we

433
00:15:26,340 --> 00:15:27,054
have more bikes.

434
00:15:27,768 --> 00:15:30,227
It's not because we can't develop molecules that

435
00:15:30,227 --> 00:15:33,345
kill bacteria because they aren't safe because a

436
00:15:33,345 --> 00:15:34,483
lot of these processes,

437
00:15:35,259 --> 00:15:38,928
protein synthesis Dna replication, mammals also have those

438
00:15:38,928 --> 00:15:42,314
processes. Yeah. So effective antibiotics that us so

439
00:15:42,612 --> 00:15:45,722
damage the host are not very useful. Not

440
00:15:45,722 --> 00:15:47,956
very useful. Yeah. Yeah. Yeah. Exactly. So as

441
00:15:47,956 --> 00:15:51,146
we think about those different mechanisms, but there's

442
00:15:51,146 --> 00:15:51,646
also

443
00:15:52,039 --> 00:15:56,059
different classes or types of antibiotics. And

444
00:15:56,600 --> 00:15:59,720
those impact both how we use them, and

445
00:15:59,799 --> 00:16:01,159
I'm gonna say how we talk about them.

446
00:16:01,334 --> 00:16:03,411
For this conversation. So the 1 I'm thinking

447
00:16:03,411 --> 00:16:06,548
of is Ion fours. And Bob, would you

448
00:16:06,607 --> 00:16:09,966
qualify Ion fours as an antibiotic and what

449
00:16:09,966 --> 00:16:11,872
makes them may be different or unique than

450
00:16:11,872 --> 00:16:14,174
some of our other antibiotics. Yeah. So an

451
00:16:14,174 --> 00:16:16,159
antibiotic basically is just a natural substance that

452
00:16:16,159 --> 00:16:17,056
is produced

453
00:16:17,604 --> 00:16:19,223
that inhibits other

454
00:16:19,682 --> 00:16:22,898
our other bacteria. And so, Ion,

455
00:16:23,437 --> 00:16:25,409
they the way they work is they change

456
00:16:25,609 --> 00:16:27,600
if you think remember that the rum is

457
00:16:27,600 --> 00:16:28,796
a is a big vat,

458
00:16:29,513 --> 00:16:31,186
with a lot of different bacteria in it

459
00:16:31,186 --> 00:16:32,062
that are breaking down.

460
00:16:32,953 --> 00:16:35,282
Forage feed into usable

461
00:16:35,657 --> 00:16:37,009
products for the rest of the body to

462
00:16:37,009 --> 00:16:39,712
use. The muscles that kidney everything else. And

463
00:16:39,712 --> 00:16:41,008
so that bacterial

464
00:16:41,382 --> 00:16:42,678
population in the room and

465
00:16:43,308 --> 00:16:45,860
it it's a bunch of different types of

466
00:16:45,860 --> 00:16:48,253
bacteria. And so what ion do is they

467
00:16:48,253 --> 00:16:51,762
actually preferential kill some types of bacteria that

468
00:16:51,762 --> 00:16:52,695
aren't as efficient

469
00:16:53,291 --> 00:16:55,382
they produce some byproducts that aren't as useful

470
00:16:55,518 --> 00:16:57,268
to the animal. And so it gives a

471
00:16:57,268 --> 00:16:59,337
kind of a an competitive advantage.

472
00:16:59,829 --> 00:17:01,904
To the bacteria in the room that are

473
00:17:01,904 --> 00:17:04,717
the most efficient at turning forage and feed

474
00:17:05,255 --> 00:17:06,451
into usable,

475
00:17:07,503 --> 00:17:09,834
you know, proteins, energies, carbohydrates

476
00:17:10,210 --> 00:17:12,678
that the volatile fatty acids that that that

477
00:17:12,678 --> 00:17:14,987
the Bo uses. And so it's a really

478
00:17:14,987 --> 00:17:17,304
neat little it's in and again, it's just

479
00:17:17,304 --> 00:17:20,397
kind of moving the the microbial population to

480
00:17:20,397 --> 00:17:22,617
give an advantage to some bacteria and a

481
00:17:22,617 --> 00:17:25,025
disadvantage to others. Well, and the other thing

482
00:17:25,025 --> 00:17:26,865
about the ion for. And again, we talk

483
00:17:26,865 --> 00:17:29,285
about... There are lots of different things

484
00:17:29,585 --> 00:17:31,984
that a veterinarian would consider before they choose.

485
00:17:32,239 --> 00:17:35,596
1 antibiotic over another, in the ion 4s

486
00:17:35,890 --> 00:17:38,272
as far as importance to human medicine. So

487
00:17:38,272 --> 00:17:40,113
that's a factor we would think about Right?

488
00:17:40,352 --> 00:17:41,782
A lot of the antibiotics we use in

489
00:17:41,941 --> 00:17:44,109
Bo production are also

490
00:17:44,721 --> 00:17:46,787
not necessarily the same molecule, but they'll be

491
00:17:46,787 --> 00:17:48,456
in the same family or same class.

492
00:17:48,948 --> 00:17:50,696
As an antibiotic that is used in human

493
00:17:50,696 --> 00:17:51,093
medicine,

494
00:17:51,649 --> 00:17:53,239
the anna fours are the kind of 1

495
00:17:53,239 --> 00:17:55,543
exception and it's because of safety. Right? The

496
00:17:55,543 --> 00:17:57,308
fours aren't safe to use in people.

497
00:17:58,183 --> 00:18:01,229
And so that that has a different regulatory

498
00:18:01,683 --> 00:18:03,218
status when we think about

499
00:18:03,609 --> 00:18:04,887
importance to human medicine,

500
00:18:05,846 --> 00:18:08,263
promoting resistance. So if we use ion force

501
00:18:08,722 --> 00:18:11,372
in cattle production, their they're we've used them

502
00:18:11,372 --> 00:18:12,888
for a long, long time, and there isn't

503
00:18:12,888 --> 00:18:16,179
really evidence that they're promoting resistance in human

504
00:18:16,238 --> 00:18:18,152
bacteria. And so, you know, that... That's a...

505
00:18:18,551 --> 00:18:20,305
Again, 1 of those factors that we think

506
00:18:20,305 --> 00:18:20,599
about

507
00:18:21,117 --> 00:18:22,154
mechanism of action.

508
00:18:23,509 --> 00:18:26,378
We we do... There are different types of

509
00:18:26,378 --> 00:18:27,972
bacteria as kind of Bob mentioned, so we

510
00:18:27,972 --> 00:18:31,113
think about gram positive bacteria versus gram, negative

511
00:18:31,250 --> 00:18:31,568
bacteria,

512
00:18:32,284 --> 00:18:35,680
aerobic bacteria versus aerobic bacteria in

513
00:18:36,117 --> 00:18:39,004
some antibiotics will only work on

514
00:18:39,459 --> 00:18:41,608
gram positives versus gram negative. Their out forces

515
00:18:41,608 --> 00:18:43,677
would be 1 of those examples. Right? So

516
00:18:43,677 --> 00:18:44,472
if we know,

517
00:18:45,443 --> 00:18:47,195
what type of infection we have if we

518
00:18:47,195 --> 00:18:49,745
think about therapeutic uses, What type of infection

519
00:18:49,745 --> 00:18:52,135
we have, we definitely wanna pick a class

520
00:18:52,135 --> 00:18:54,547
of antibiotic that has activity against

521
00:18:54,859 --> 00:18:57,095
that type or if there's a couple different

522
00:18:57,095 --> 00:18:59,250
bacteria that may cause it. Pastor element h,

523
00:18:59,729 --> 00:19:01,725
causing respiratory disease, those are gram negatives. We

524
00:19:01,725 --> 00:19:03,721
wanna pick an antibiotic that has gram negative

525
00:19:03,721 --> 00:19:04,040
spectrum.

526
00:19:04,533 --> 00:19:07,475
Well, and another thing, so specifically for ion

527
00:19:07,475 --> 00:19:09,327
fours, different antibiotics

528
00:19:10,020 --> 00:19:12,167
will go to different tissues. And and they're

529
00:19:12,167 --> 00:19:14,418
delivered in different away. So ion are delivered

530
00:19:14,418 --> 00:19:16,496
orally in the feed, and they tend to

531
00:19:16,496 --> 00:19:18,254
stay in the gut in the digestive tract.

532
00:19:18,493 --> 00:19:19,772
They don't go to the other tissues.

533
00:19:20,651 --> 00:19:22,545
And so that would be, you know, for

534
00:19:22,743 --> 00:19:24,175
those are the types of things that a

535
00:19:24,175 --> 00:19:26,959
veterinarian thinks about when they pick, which antibiotics

536
00:19:26,959 --> 00:19:29,107
uses is well... What tissue does it go

537
00:19:29,107 --> 00:19:31,352
to. What route of administration do we use

538
00:19:31,352 --> 00:19:32,626
so that it gets to the tissue that

539
00:19:32,786 --> 00:19:34,538
I want it to or maybe to not

540
00:19:34,538 --> 00:19:35,971
go to tissues that I don't want it

541
00:19:35,971 --> 00:19:38,933
to. You you mentioned Spectrum Brian. So... A

542
00:19:38,933 --> 00:19:40,364
lot of times they think of... And you'll

543
00:19:40,364 --> 00:19:43,226
hear the term broad spectrum antibody. Does that

544
00:19:43,226 --> 00:19:44,975
mean it gets everything and I could just

545
00:19:44,975 --> 00:19:47,770
use 1 antibiotic and get good at using

546
00:19:47,770 --> 00:19:50,255
that 1, or am I gonna need different

547
00:19:50,310 --> 00:19:51,684
antibiotics for different circumstance?

548
00:19:52,136 --> 00:19:52,295
Well,

549
00:19:53,168 --> 00:19:55,525
actually, broad versus neuro spectrum is

550
00:19:55,882 --> 00:19:58,348
really poorly defined. But I mean, that's the

551
00:19:58,348 --> 00:20:00,576
general concept. Right? Is it broad spectrum,

552
00:20:01,451 --> 00:20:02,428
antibiotic covers

553
00:20:03,217 --> 00:20:05,848
gram positive and gram negatives. Arrow, and. Right?

554
00:20:06,008 --> 00:20:09,357
So they're they're big categories bit even there

555
00:20:09,357 --> 00:20:11,845
are exceptions within those and there's certain there

556
00:20:11,845 --> 00:20:14,664
are particular bacteria within each of those

557
00:20:14,964 --> 00:20:15,865
classifications that

558
00:20:16,244 --> 00:20:18,085
1 antibiotic may get and 1 may not.

559
00:20:18,244 --> 00:20:20,019
Right? And again, kind of boils down to

560
00:20:20,019 --> 00:20:22,819
the mechanism of action, So is it a

561
00:20:22,819 --> 00:20:25,460
protein synthesis inhibitor or a cell wall inhibitor.

562
00:20:25,700 --> 00:20:26,200
But

563
00:20:26,740 --> 00:20:28,507
I And 1 of the things when we

564
00:20:28,507 --> 00:20:31,530
talk about antibiotics and producers getting more information,

565
00:20:32,485 --> 00:20:35,285
we we tend to kinda get... Trapped with

566
00:20:35,444 --> 00:20:37,431
B. It's our biggest disease challenge. And we

567
00:20:37,431 --> 00:20:39,816
often think about B d, and most of

568
00:20:39,816 --> 00:20:42,996
the antibiotics are approved for B for those

569
00:20:42,996 --> 00:20:43,711
reasons. Right?

570
00:20:44,364 --> 00:20:46,440
And if you really if you really wanna

571
00:20:46,440 --> 00:20:48,595
have a discussion and learn more about antibiotics

572
00:20:48,595 --> 00:20:50,352
and why you would choose 1 over another

573
00:20:50,352 --> 00:20:52,688
1. Again, I I would involve a veteran

574
00:20:52,826 --> 00:20:55,339
involve your veterinarian and, but think about different

575
00:20:55,400 --> 00:20:56,859
kinds of cases. So

576
00:20:57,240 --> 00:20:58,700
the antibiotic we choose

577
00:20:59,000 --> 00:21:00,679
for Bo respiratory disease,

578
00:21:01,252 --> 00:21:02,782
caused by Mann jaime

579
00:21:03,154 --> 00:21:05,215
is may not be the same 1 we

580
00:21:05,215 --> 00:21:09,513
choose for my plasma pneumonia or certainly probably

581
00:21:09,513 --> 00:21:11,103
not the same 1 we would choose for

582
00:21:11,103 --> 00:21:13,806
my plasma, arthritis or ear infections. Right? Or

583
00:21:13,806 --> 00:21:16,112
think about foot rot is a different disease

584
00:21:16,112 --> 00:21:17,861
where the spectrum could matter,

585
00:21:18,990 --> 00:21:20,422
and you would pick it... You may pick

586
00:21:20,422 --> 00:21:23,206
a different antibiotic because of the difference. So

587
00:21:23,206 --> 00:21:25,058
think about different disease challenges

588
00:21:25,368 --> 00:21:27,197
and that'll help you get a little more

589
00:21:27,197 --> 00:21:29,662
understanding about different classes and what you should

590
00:21:29,662 --> 00:21:32,683
be using for those diseases. And basically, 3

591
00:21:32,683 --> 00:21:35,243
semesters of that's school. 3 semesters about school

592
00:21:35,959 --> 00:21:38,185
Would help to. But they're in and in

593
00:21:38,185 --> 00:21:39,934
1 of the I did answer 1 of

594
00:21:39,934 --> 00:21:41,843
the listener questions via email. He said, you

595
00:21:41,843 --> 00:21:43,768
know, talk to your veterinarian and We use

596
00:21:43,768 --> 00:21:47,201
formula. So those are... They're basically condensed books

597
00:21:47,201 --> 00:21:49,675
of drug labels. They often talk give a

598
00:21:49,675 --> 00:21:51,432
little background on the drug, how it works,

599
00:21:51,591 --> 00:21:52,150
the class.

600
00:21:53,521 --> 00:21:55,754
Some of them have doses, but, again, you

601
00:21:55,754 --> 00:21:57,030
really need to talk to your veterinarian when

602
00:21:57,030 --> 00:21:59,184
you get into the dose specifics, but they'll

603
00:21:59,184 --> 00:22:01,417
talk about side effects, spec. All the things

604
00:22:01,417 --> 00:22:03,665
we're talking about. That's all kinda condensed in

605
00:22:03,665 --> 00:22:06,616
a formula. And so for for general knowledge,

606
00:22:06,856 --> 00:22:08,849
that's good when you get into the specific

607
00:22:08,849 --> 00:22:09,647
clinical uses,

608
00:22:10,285 --> 00:22:12,612
certainly need to involve your veterinarian. Yeah. Some

609
00:22:12,612 --> 00:22:14,285
of the things that as a veterinarian you

610
00:22:14,285 --> 00:22:16,277
think about is... And and the reason that

611
00:22:16,277 --> 00:22:18,507
we don't want to overuse antibiotics. 1 that

612
00:22:18,507 --> 00:22:20,499
people are probably aware of is is resistance.

613
00:22:20,738 --> 00:22:21,295
We don't wanna...

614
00:22:21,867 --> 00:22:22,606
Select for

615
00:22:23,061 --> 00:22:25,367
resistance where the antibiotics don't work anymore. But

616
00:22:25,367 --> 00:22:26,322
there's other things too.

617
00:22:27,197 --> 00:22:29,043
There are some antibiotics that that might be

618
00:22:29,043 --> 00:22:30,717
kind of hard on the kidney it cause

619
00:22:30,717 --> 00:22:33,348
kidney damage if the animal is dehydrated. So

620
00:22:33,348 --> 00:22:35,820
the animal itself, it might be an antibiotic

621
00:22:35,820 --> 00:22:38,407
that would work if the animal was... Hydrated

622
00:22:38,464 --> 00:22:41,008
and and doing well other than what I'm

623
00:22:41,008 --> 00:22:42,757
trading it for. But if he's dehydrated and

624
00:22:42,757 --> 00:22:44,823
he's... That maybe a really go had bad

625
00:22:44,823 --> 00:22:47,066
choice. The other 1 when we talk about

626
00:22:47,066 --> 00:22:48,658
food animals, animals that are gonna go into

627
00:22:48,658 --> 00:22:50,648
the food system is how long they stick

628
00:22:50,648 --> 00:22:53,377
around the body, so the withdrawal time. So

629
00:22:53,529 --> 00:22:55,439
you know, 1 of the reasons that, we

630
00:22:55,439 --> 00:22:58,145
don't just use antibiotics without thinking about it

631
00:22:58,145 --> 00:22:59,339
is resistance,

632
00:23:00,453 --> 00:23:00,931
side effects.

633
00:23:01,585 --> 00:23:02,085
And

634
00:23:02,785 --> 00:23:05,105
withdrawal time. And so that's... Again, that's... It...

635
00:23:05,345 --> 00:23:07,205
It's kinda complicated pretty fast

636
00:23:07,825 --> 00:23:08,279
and

637
00:23:08,636 --> 00:23:11,650
making wise antibiotic decisions is really part of

638
00:23:11,650 --> 00:23:13,632
what both veterinarians and producers are asked to

639
00:23:13,632 --> 00:23:15,615
do. I think that's important and being able

640
00:23:15,615 --> 00:23:16,115
to

641
00:23:16,504 --> 00:23:20,175
justify your rationale that you selected that specific

642
00:23:20,175 --> 00:23:22,330
drug for that treatment, and that's where you're

643
00:23:22,330 --> 00:23:24,086
working with your veterinarian. And both of you

644
00:23:24,086 --> 00:23:24,586
mentioned

645
00:23:24,977 --> 00:23:26,722
go to the label. The other thing that

646
00:23:26,881 --> 00:23:30,056
I would say, different drug names or different

647
00:23:30,056 --> 00:23:33,904
brand names don't necessarily mean that they are

648
00:23:33,961 --> 00:23:36,428
dramatically different in term... Especially in terms of

649
00:23:36,428 --> 00:23:38,736
class of drug that they're in, meaning they

650
00:23:38,736 --> 00:23:41,537
may work very similarly to something else that's

651
00:23:41,537 --> 00:23:43,210
something that's hard to pick up unless you

652
00:23:43,210 --> 00:23:45,042
have some background knowledge. So talk talk to

653
00:23:45,042 --> 00:23:48,070
your veterinarian and great information. Appreciate both of

654
00:23:48,070 --> 00:23:50,141
you sharing some of that. And appreciate everything

655
00:23:50,141 --> 00:23:52,712
else. That we talked about today. And if

656
00:23:52,712 --> 00:23:55,029
you have a question topic or thing you'd

657
00:23:55,029 --> 00:23:56,867
like us to talk about on future, so

658
00:23:56,867 --> 00:23:58,625
send us an email, Bc at You.